Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Excel Ingredients & Drug Interactions

by Endurox

Excel label
See full label image
Other (e.g. Tea Bag) Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Excel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Excel is a dietary supplement by Endurox with 2 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,170 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ciwujia, Vitamin E. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Excel by Endurox

Ask about any prescription or over-the-counter medication and we check it for interactions with Excel by Endurox — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Excel by Endurox

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Endurox Excel contains 2 active ingredients: vitamin E and ciwujia (also called eleuthero or Siberian ginseng). Vitamin E is a fat-soluble antioxidant that plays a role in protecting cells from damage and is essential for normal blood clotting and immune function.

Ciwujia is an herbal extract traditionally used as an adaptogen to support energy and endurance. The product also contains several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, stearic acid, film coat, croscarmellose sodium, silica, and magnesium stearate — which serve as fillers, binders, and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: exercise performance, fat metabolism, and muscle recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Physical performance, Endurance, Muscle strength, Energy metabolism.
  • The strongest evidence on file: Vitamin E is rated "Possibly Effective" for Exercise-induced muscle damage (Natural Medicines).
  • Also on file: Vitamin E is rated "Insufficient Reliable Evidence To Rate" for Physical performance.
  • Also on file: Eleuthero is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

For vitamin E, the evidence is strongest for treating vitamin E deficiency itself and a rare genetic condition called AVED (ataxia with vitamin E deficiency), where it's considered effective. It's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage, though the evidence is less established.

For ciwujia, the data we hold shows possibly effective evidence only for genital herpes. For other uses listed — familial Mediterranean fever, bipolar disorder, osteoporosis, and chronic fatigue syndrome — the evidence is insufficient to rate.

The product's intended use as an endurance supplement isn't reflected in the effectiveness ratings on file.

The evidence, ingredient by ingredient Vitamin E Eleuthero

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well-tolerated in usual dietary amounts. However, high-dose long-term supplements may raise bleeding risk and other harms.

Serious but rare side effects include bleeding, hemorrhagic stroke, and cardiovascular complications. There is some concern about hemorrhagic stroke with high-dose synthetic vitamin E, though other studies have shown no significantly increased risk.

High doses can also increase bleeding due to interference with clotting factors and platelet function, especially in people with vitamin K deficiency or those taking blood thinners. Ciwujia is generally well-tolerated for short-term use, but long-term safety data are limited.

Common side effects include diarrhea, indigestion, headache, nausea, and skin rashes. Some people report nervousness, anxiety, irritability, or low mood, especially at higher doses.

Eleuthero has also been reported to raise blood pressure and cause rapid heart rate, particularly in people with heart conditions. During pregnancy and breastfeeding, safety data are insufficient, so it's best avoided in both situations.

Vitamin E amounts from food and prenatal vitamins are appropriate during pregnancy and lactation, but avoid high-dose supplements unless directed by your doctor.

Side effects, ingredient by ingredient Vitamin E Eleuthero

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin E, Eleuthero.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; heart-rhythm medications.
  • For scale: 1,171 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Endurox Excel, double-check these medication types with your pharmacist: blood thinners and antiplatelet drugs (Major bleeding risk from vitamin E); chemotherapy drugs, especially alkylating agents and antitumor antibiotics (vitamin E may reduce effectiveness); immunosuppressants (eleuthero may interfere); diabetes medications (eleuthero may add blood-sugar-lowering effects); digoxin for the heart (eleuthero may increase levels); drugs metabolized by your liver through CYP1A2, CYP2C9, CYP2D6 pathways, or via P-glycoprotein transporter (eleuthero may increase levels); cyclosporine (vitamin E may increase levels); cholesterol medications like niacin (vitamin E may reduce effectiveness); and selumetinib cancer drug (vitamin E combination may increase bleeding risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Endurox Excel may appeal to people looking to support endurance, but it carries significant interaction potential — especially if you take blood thinners, chemotherapy drugs, immunosuppressants, or heart and diabetes medications. The safety profile for long-term use of ciwujia is not well established.

Check all your medications with the tool on this page, and talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Excel, straight from the product label.

Brand Endurox
Barcode (UPC) 605439030118
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 72199
Product type Botanical With Nutrients
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Excel by Endurox, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplet(s)
Maximum serving Sizes:
2 Caplet(s)
Servings per container
30
UPC/BARCODE
605439030118
IngredientAmount% DV
Vitamin E60 IU200%
Ciwujia1200 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Film Coat, Croscarmellose Sodium, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Natural exercise supplement Increases fat metabolism up to 43% Makes a hard workout easier Speeds muscle recovery Get leaner faster (30-day supply)

PacificHealth We power your passion

Printed in USA.

During exercises, Endurox Excel: Increases the metabolism of fat up to 43% Builds endurance thereby making your hard workouts easier Slows the buildup of lactic acid Speeds muscle recovery by preventing free radical buildup Endurox Excel is not a stimulant and has been used extensively without reported side effects.

General

12 384954 03/14 F5110012

Brand IP Statement(s)

Guarantee: If you use Endurox Excel for 1 month and do not see an improvement in your training performance, PacificHealth Laboratories, Inc., will give you a full refund.

2014 Rev 1 Endurox and Excel are trademarks of Mott's LLP. All rights reserved. US Patent #5,585,101

Endurox Excel dietary supplement, taken as part of your training and exercise regimen, can help you get leaner faster and improve exercise performance.

Storage

Store at 59-86(0)F (15-30(0)C). Protect from heat, light and moisture.

FDA Statement of Identity

Endurox Excel dietary supplement, taken as part of your training and exercise regimen, can help you get leaner faster and improve exercise performance.

Suggested/Recommended/Usage/Directions

Recommended Serving: Adults: As a dietary supplement, take two (2) caplets once daily.

Precautions

In case of accidental overdose, seek professional advice immediately.

If you are taking prescription medication or are pregnant or lactating, contact your doctor before taking Endurox Excel.

Sealed for your protection. Do not use if individual blister seals are broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Excel by Endurox label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Excel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Excel by Endurox

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
60 IU per serving Form: D-Alpha-Tocopheryl Succinate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Ciwujia

Interacts with
1,140 drugs
1200 mg per serving Form: Eleuthero root extract

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...

Ciwujia monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Film Coat, Croscarmellose Sodium, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Excel by Endurox Drug Interactions

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Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,170Drugs
1,093 Moderate 77 Minor

Ingredients driving the most interactions

Ciwujia 1,140
Vitamin E 764

Individual Drug Interactions

The ingredients in Excel interact with 1,170 drugs. Click any drug to see the details.

2 of the 2 ingredients in Excel interact with drugs. Each result below shows which ingredient is responsible. Ciwujia Vitamin E

Each ingredient & the kinds of drugs it affects

For each ingredient in Excel with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ciwujia10 drug types · 1,140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Ciwujia full monograph & interactions

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Excel, from the product label.

Endurox

See all Endurox products
Name
PacificHealth Laboratories, Inc.
Street Address
100 Matawan Road
City
Matawan
State
NJ
ZipCode
07747
Pharmacist Counseling Corner

Excel by Endurox: Common Questions

Does Excel by Endurox interact with any medications?
Yes. Based on its ingredients, Excel has a known interaction with 1,170 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Excel contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Endurox Excel if I'm pregnant or breastfeeding?
The safety data on ciwujia aren't sufficient to recommend it during pregnancy or breastfeeding — it's best avoided in both situations. Vitamin E amounts from food and prenatal vitamins are fine, but avoid high-dose supplements unless your doctor directs it. Talk with your doctor or pharmacist before starting this product.
What's ciwujia, and what is it supposed to do?
Ciwujia, also called eleuthero or Siberian ginseng, is an herbal extract traditionally used as an adaptogen — a substance believed to help your body handle stress and support energy. In the research we have, it shows possibly effective evidence only for genital herpes; evidence for other uses is insufficient to rate.
What are the most common side effects of this product?
Ciwujia can cause diarrhea, indigestion, headache, nausea, and skin rashes. Some people report nervousness, anxiety, or irritability, especially at higher doses. Vitamin E is generally well-tolerated, but high doses increase the risk of bleeding.
Can this product affect how my blood thinner works?
Yes. Both vitamin E and ciwujia may increase bleeding risk when used with blood thinners or antiplatelet drugs like aspirin. This is one of the most serious interactions — talk with your pharmacist or doctor before combining them.
Is this product safe to take long-term?
Vitamin E in usual dietary amounts is safe long-term, but high-dose long-term supplements may raise bleeding risk and other harms. Ciwujia is generally well-tolerated for short-term use, but long-term safety evidence is limited. Talk with your pharmacist about how long it's appropriate for you to take this product.
Does this product contain any fillers?
Yes. Endurox Excel contains inactive ingredients including dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, silica, and magnesium stearate, which serve as binders, fillers, and capsule material.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Excel label
Go deeper

The Full Monographs Behind Excel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Eleuthero

Interacts with 1,140 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph →
Sources

Sources & How We Checked

Excel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
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See these in context on the Vitamin E monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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