Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Eye Remedy Tangerine Smoothie Ingredients & Drug Interactions

by Barlean's Seriously Delicious

Eye Remedy Tangerine Smoothie label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Eye Remedy Tangerine Smoothie against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Eye Remedy Tangerine Smoothie is a dietary supplement by Barlean's Seriously Delicious with 6 active ingredients. Its ingredients are commonly taken for antioxidant support, heart health, brain and memory health.Based on those ingredients, 1,117 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape Seed Extract, Astaxanthin, Natural, Omega-3 Polyunsaturated Fat. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious

Ask about any prescription or over-the-counter medication and we check it for interactions with Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • “Omega-3 Polyunsaturated Fat” is listed as a grouped ingredient — the label gives one combined amount (1,250 mg) without saying how much of each component you get.

Eye Remedy Tangerine Smoothie is a liquid formula with 10 active ingredients. The largest group is omega-3 fatty acids—eicosapentaenoic acid, docosahexaenoic acid, and other omega-3s derived from fish oil—alongside lutein and zeaxanthin isomers, two antioxidants that accumulate in your eyes.

You'll also get blueberry extract, grape seed extract, and astaxanthin (a natural carotenoid), plus smaller amounts of monounsaturated and polyunsaturated fats. The product also contains inactive ingredients like water, xylitol, glycerin, citric acid, gum arabic, xanthan gum, and vitamin E for preservation.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: protect eyes and support macular health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Dry eye, blue light protection, digital eye fatigue — and 1 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

The evidence for this product's ingredients is mixed. Lutein is possibly effective for age-related macular degeneration and cataracts—the eye conditions this product targets.

Zeaxanthin isomers are also possibly effective for age-related macular degeneration. However, grape seed extract is possibly effective only for chronic venous insufficiency (leg swelling), not eye health.

Blueberry extract shows insufficient evidence for most conditions, though it's possibly ineffective for high blood pressure. Astaxanthin has insufficient evidence for cognitive decline, macular degeneration, or aging skin.

The fish-derived omega-3 fatty acids in this product have no effectiveness ratings listed in our data. Overall, lutein and zeaxanthin have the strongest evidence for the eye-related claims.

The evidence, ingredient by ingredient Blueberry Grape Lutein Zeaxanthin Astaxanthin Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blueberry extract and grape seed extract are generally well tolerated; the most common side effects are mild gastrointestinal complaints like diarrhea, nausea, and diarrhea. In one freeze-dried blueberry trial, 26% of participants stopped due to stomach upset in the first week.

Lutein and zeaxanthin are well tolerated at typical doses—lutein up to 20 mg daily caused no reported adverse effects. Astaxanthin is generally well tolerated but has caused abdominal pain, diarrhea, and red-colored stool; at higher doses (40 mg daily), severe stomach pain has occurred in rare cases.

For pregnancy, grape seed extract and lutein are rated likely safe, and zeaxanthin is also likely safe; however, astaxanthin safety data are insufficient and it's best avoided during pregnancy. Blueberry extract safety in pregnancy is uncertain—whole blueberries are fine, but concentrated supplements haven't been well studied.

For breastfeeding, safety data are limited for all concentrated extracts; whole foods are fine, but check with your doctor about supplement doses.

Side effects, ingredient by ingredient Blueberry Grape Lutein Zeaxanthin Astaxanthin Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Grape, Blueberry, Astaxanthin, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,003 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications against these drug types before using this product. Grape seed extract can affect blood thinners and antiplatelet drugs (Moderate risk of increased bleeding), drugs metabolized by CYP3A4, CYP2D6, and CYP2B6 enzymes (Moderate risk of changed blood levels), cyclosporine (Moderate risk of reduced absorption—space doses 2+ hours apart), and midazolam and other sedatives (Moderate risk of reduced effect).

Blueberry extract may increase low blood sugar risk with antidiabetes drugs and can increase flurbiprofen and buspirone levels (all Minor). Antidiabetes drugs also interact with zeaxanthin (Moderate).

Astaxanthin may lower levels of CYP3A4 and CYP2B6 substrate drugs (Moderate). Use the medication search tool on this page to verify your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is built around lutein and zeaxanthin, which have decent evidence for supporting eye health and may help slow age-related macular degeneration and cataracts. It's generally well tolerated, though some people experience mild stomach upset.

The catch is grape seed extract's multiple Moderate-severity interactions with common medications, plus potential effects from astaxanthin and blueberry. If you take any prescription medications—especially blood thinners, antidiabetes drugs, antidepressants, heart drugs, or immunosuppressants—talk to your pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Eye Remedy Tangerine Smoothie, straight from the product label.

Brand Barlean's Seriously Delicious
Barcode (UPC) 705875600217
Net contents 16 Ounce(s); 1 Pound(s); 454 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337680
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15.9 Gram(s)
Maximum serving Sizes:
15.9 Gram(s)
Servings per container
29
UPC/BARCODE
705875600217
IngredientAmount% DV
Calories60 Calorie(s)--
Total Carbohydrates6 Gram(s)2%
Eicosapentaenoic Acid607 mg--
Docosahexaenoic Acid393 mg--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Cholesterol25 mg8%
Total Fat4 Gram(s)5%
Saturated Fat1 Gram(s)5%
Sugar Alcohol5 Gram(s)--
Other Omega-3 Fatty Acids250 mg--
Blueberry Extract75 mg--
Grape Seed Extract25 mg--
Polyunsaturated Fat1.5 Gram(s)--
Lutein12 mg--
Monounsaturated Fat1 Gram(s)--
Zeaxanthin Isomers2.5 mg--
Astaxanthin, Natural2 mg--
Omega-3 Polyunsaturated Fat1250 mg--

Other ingredients: Water, Fish Oil, Xylitol, Glycerin, Gum Arabic, Natural Flavors, Lutemax 2020, Citric Acid, Xanthan Gum, Vitamin E, Rosemary Extract, Ascorbyl Palmitate, Green Tea Extract, Astaxanthin, Natural, Guar Gum, Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hello! We're Barlean's and we make premium foods and nutritional supplements here in the Pacific Northwest. We're all about creating seriously delicious ways for people to get the nutrients they need while we make a difference in our world.

Barlean's Estd 1989

Learn more about a pathway to a better life: Barleans.com 800.445.3529

Formulation

Screen out harmful blue light Spending a lot of time in front of digital screens can lead to eye fatigue, strain and potential long-term damage. That's why we created Eye Remedy: Helps protect eyes while supporting macular health Better absorption Sweet taste & creamy texture

No artificial flavors or colors

Sugar free Gluten free Non-GMO Dairy free

Protects your eyes from harmful blue light

Product of U.S.A.

Formula

With Lutemax 2020 Lutein and Zeaxanthin Contains Lutemax 2020, to help filter out harmful, high-energy blue light from electronic devices Provides your daily serving of essential omega-3s from Fresh Catch Fish Oil A potent combination of omega-3s, natural carotenoids and antioxidants support optimum vision and macular health Our proprietary emulsified formula is absorbed better than traditional oils, so you get more of the nutrients you're after.

Omega-3 + Eye nutrition EPA/DHA 1,000mg 12 mg Lutein 2 mg Astaxanthin Natural fruit flavor

Suggested/Recommended/Usage/Directions

Suggested use: 1 Tbsp up to 2x daily. Delicious straight off the spoon or in yogurt, oatmeal or smoothies. Spoon Top Blend Shake well

Precautions

Keep out of reach of children and never give to pets.

Storage

Refrigerate after opening

Brand IP Statement(s)

Lutemax 2020 is a trademark of OmniActive Health Technologies Ltd.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Eye Remedy Tangerine Smoothie label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size15.9 Gram(s) Dosage formLiquid Servings per container29 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blueberry Extract

Interacts with
88 drugs
75 mg per serving

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...

Blueberry Extract monograph & interactions

Grape Seed Extract

Interacts with
910 drugs
25 mg per serving

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Grape Seed Extract monograph & interactions

Lutein

No known
interactions
12 mg per serving Form: Marigold

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin Isomers

Interacts with
86 drugs
2.5 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin Isomers monograph & interactions

Astaxanthin, Natural

Interacts with
671 drugs
2 mg per serving Form: Haematococcus pluvialis

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin, Natural monograph & interactions

Omega-3 Polyunsaturated Fat

Interacts with
375 drugs
1250 mg per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Polyunsaturated Fat monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids

Other (inactive) ingredients: Water, Fish Oil, Xylitol, Glycerin, Gum Arabic, Natural Flavors, Lutemax 2020, Citric Acid, Xanthan Gum, Vitamin E, Rosemary Extract, Ascorbyl Palmitate, Green Tea Extract, Astaxanthin, Natural, Guar Gum, Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious Drug Interactions

Want to check YOUR meds against Eye Remedy Tangerine Smoothie?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,117Drugs
1,096 Moderate 21 Minor

Ingredients driving the most interactions

Grape Seed Extract 910
Astaxanthin, Natural 671
Omega-3 Polyunsaturated Fat 375
Blueberry Extract 88
Zeaxanthin Isomers 86

Individual Drug Interactions

The ingredients in Eye Remedy Tangerine Smoothie interact with 1,117 drugs. Click any drug to see the details.

5 of the 6 ingredients in Eye Remedy Tangerine Smoothie interact with drugs. Each result below shows which ingredient is responsible. Grape Seed Extract Astaxanthin, Natural Omega-3 Polyunsaturated Fat Blueberry Extract Zeaxanthin Isomers

Each ingredient & the kinds of drugs it affects

For each ingredient in Eye Remedy Tangerine Smoothie with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape Seed Extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape Seed Extract full monograph & interactions

Astaxanthin, Natural2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin, Natural full monograph & interactions

Omega-3 Polyunsaturated Fat3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Polyunsaturated Fat full monograph & interactions

Blueberry Extract3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D
Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B
Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B
Blueberry Extract full monograph & interactions

Zeaxanthin Isomers1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin Isomers full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Eye Remedy Tangerine Smoothie, from the product label.

Barlean's Seriously Delicious

See all Barlean's Seriously Delicious products
Name
Barlean's
City
Ferndale
State
WA
ZipCode
98248
Phone Number
800-445-3529
Web Address
barleans.com
Pharmacist Counseling Corner

Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious: Common Questions

Does Eye Remedy Tangerine Smoothie by Barlean's Seriously Delicious interact with any medications?
Yes. Based on its ingredients, Eye Remedy Tangerine Smoothie has a known interaction with 1,117 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Eye Remedy Tangerine Smoothie contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product supposed to help with?
The main active ingredients—lutein and zeaxanthin—have evidence suggesting they may help slow age-related macular degeneration and cataracts. The formula also includes blueberry, grape seed, and astaxanthin extracts, along with omega-3 fatty acids from fish oil, though evidence for those in eye health is weaker or not yet established.
Can I take this if I'm pregnant?
Grape seed extract and lutein are rated likely safe in pregnancy, as is zeaxanthin. However, astaxanthin safety data are insufficient—it's best to avoid it during pregnancy. Blueberry extract safety is uncertain when taken as a concentrated supplement during pregnancy, so talk to your doctor or pharmacist before starting. Whole blueberries are fine to eat.
What are the most common side effects?
Mild stomach issues are most common: diarrhea, nausea, or constipation, especially from the blueberry extract. In one trial, about 1 in 4 participants using freeze-dried blueberries quit due to gastrointestinal complaints in the first week. Astaxanthin may also cause red-colored stool or diarrhea at typical doses.
Is this safe to take long-term?
Lutein, zeaxanthin, blueberry, and grape seed extract are generally well tolerated for extended use based on available safety data. Astaxanthin has limited long-term safety data, so we don't have strong information on its safety over months or years. Check with your pharmacist if you plan to use this product regularly for more than a few months.
Can I take this with my blood thinner?
Grape seed extract in this product theoretically increases bleeding risk with blood thinners and antiplatelet drugs. You need to check your exact medication with your pharmacist before starting—do not assume it's safe based on this answer, as individual medications vary.
Does this product work for dry eyes?
Our data don't include effectiveness information for dry eyes. The product is built around lutein and zeaxanthin for macular degeneration and cataracts. Talk to your eye doctor or pharmacist about whether the ingredients in this formula are appropriate for your specific condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Eye Remedy Tangerine Smoothie is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Eye Remedy Tangerine Smoothie label
Go deeper

The Full Monographs Behind Eye Remedy Tangerine Smoothie’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph →
Sources

Sources & How We Checked

Eye Remedy Tangerine Smoothie's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 99 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blueberry 7 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
  3. Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
  4. Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
  5. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
  6. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
  7. Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

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Grape 34 references
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  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
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  33. Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome mark
  34. Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515. PubMed

See these in context on the Grape monograph →

Lutein 2 references
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  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
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See these in context on the Zeaxanthin monograph →

Astaxanthin 3 references
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  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Docosahexaenoic Acid (dha) 49 references
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