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Dietary supplement

Fadogia agrestis & Tongkat Ali Ingredients & Drug Interactions

by tnvitamins

Fadogia agrestis & Tongkat Ali label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fadogia agrestis & Tongkat Ali against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fadogia agrestis & Tongkat Ali is a dietary supplement by tnvitamins with 2 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fadogia agrestis & Tongkat Ali by tnvitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Fadogia agrestis & Tongkat Ali by tnvitamins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fadogia agrestis & Tongkat Ali by tnvitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: Tongkat Ali Root Extract and Fadogia agrestis Stem Extract. Tongkat Ali, also called Eurycoma longifolia, is a traditional botanical used for sexual desire and general vitality in men.

Fadogia agrestis is an African plant extract included for its traditional uses, though its effects aren't yet well-studied in humans. The capsules also contain inactive ingredients—magnesium stearate, rice flour, and gelatin—which are fillers and binders that help form the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Eurycoma Longifolia) (Natural Medicines).

For Tongkat Ali, the evidence shows it's possibly effective for sexual desire in men; that's the strongest rating in the data. For athletic performance, the evidence leans toward possibly ineffective.

The data we have doesn't establish reliable evidence for back pain, osteoporosis, or diabetes. For Fadogia agrestis, the evidence we hold isn't established—there isn't enough reliable data to rate it for athletic performance, erectile dysfunction, or malaria.

If you're taking either ingredient for a specific reason, it's worth asking your pharmacist what the research actually shows for your situation.

The evidence, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali is generally well tolerated in short-term studies, but long-term safety isn't well known and product quality can vary between brands. If your body's testosterone levels go beyond the normal range—which Tongkat Ali may cause—you could develop acne, insulin resistance (trouble controlling blood sugar), liver damage, and other testosterone-related side effects.

Avoid it during pregnancy and breastfeeding due to insufficient safety data and potential hormonal effects. Fadogia agrestis has very little human safety data.

Animal studies raise concerns about possible damage to the testicles, liver, and kidneys. It should be avoided during pregnancy and breastfeeding because no safety data exist for those periods.

Side effects, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take propranolol (Inderal) or any other beta-blocker for your heart or blood pressure—Tongkat Ali can reduce their effectiveness. Also double-check if you're on any drug that your liver processes through CYP1A2, CYP2C19, or CYP2A6 enzymes, and if you're taking testosterone replacement therapy.

Use the medication checker on this page with your exact drugs before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tongkat Ali is used by men for sexual desire and has the strongest evidence in this product, but it interacts with propranolol and may raise testosterone. Fadogia agrestis has almost no human safety or effectiveness data and raises toxicity concerns from animal studies.

If you take a beta-blocker, use testosterone therapy, or take any prescription medication, check with your pharmacist before starting. Pregnant or breastfeeding?

Skip this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fadogia agrestis & Tongkat Ali, straight from the product label.

Brand tnvitamins
Barcode (UPC) X0042P1PVX
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336934
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fadogia agrestis & Tongkat Ali by tnvitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X0042P1PVX
IngredientAmount% DV
Tongkat Ali Root Extract750 mg--
Fadogia agrestis Stem Extract750 mg--

Other ingredients: Magnesium Stearate, Rice Flour, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take two (2) capsules daily, or as directed by a healthcare professional.

General Statements

New 120 caps

Precautions

Caution: Pregnant or lactating women should consult a doctor before use.

If you are under medical supervision, please consult a doctor before use. Discontinue use and consult a doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Fadogia agrestis & Tongkat Ali 1500 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Packaged & Lab Tested in the USA

Formulation

Non GMO Gluten free Nuts free Free of: Gluten, wheat, yeast, soy, peanuts, tree nuts, fish, crustaceans, sugar & dairy. No artificial colors or flavors. Non-GMO.

100% Natural

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fadogia agrestis & Tongkat Ali by tnvitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fadogia agrestis & Tongkat Ali label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fadogia agrestis & Tongkat Ali by tnvitamins

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tongkat Ali Root Extract

Interacts with
248 drugs
750 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali Root Extract monograph & interactions

Fadogia agrestis Stem Extract

No known
interactions
750 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestis Stem Extract monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Rice Flour, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fadogia agrestis & Tongkat Ali by tnvitamins Drug Interactions

Want to check YOUR meds against Fadogia agrestis & Tongkat Ali?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali Root Extract 248

Individual Drug Interactions

The ingredients in Fadogia agrestis & Tongkat Ali interact with 248 drugs. Click any drug to see the details.

1 of the 2 ingredients in Fadogia agrestis & Tongkat Ali interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fadogia agrestis & Tongkat Ali with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fadogia agrestis & Tongkat Ali, from the product label.

tnvitamins

See all tnvitamins products
Name
Total Nutrition, Inc.
City
Farmingdale
State
NY
ZipCode
11735
Phone Number
1 (800) 245-7955
Web Address
TNVitamins.com
Pharmacist Counseling Corner

Fadogia agrestis & Tongkat Ali by tnvitamins: Common Questions

Does Fadogia agrestis & Tongkat Ali by tnvitamins interact with any medications?
Yes. Based on its ingredients, Fadogia agrestis & Tongkat Ali has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fadogia agrestis & Tongkat Ali contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on propranolol or another blood pressure medication?
Not without talking to your pharmacist first. Tongkat Ali can lower propranolol levels by about 29%, which means your blood pressure control could slip. Your pharmacist needs to know what you're taking so they can help you decide if it's safe and whether your dose might need adjusting.
Is Tongkat Ali safe to use long-term?
The studies we have are mostly short-term, so we don't know how safe it is over years. Also, if your testosterone gets pushed above normal range, you risk acne, liver problems, and insulin resistance. Talk with your pharmacist about how long you plan to use it.
What's the evidence that Tongkat Ali actually works for sexual desire?
The evidence we hold rates it as possibly effective for sexual desire in men—that's the strongest rating for this product. For athletic performance, though, the evidence leans toward possibly ineffective.
Why should I avoid this during pregnancy and breastfeeding?
Tongkat Ali may raise testosterone and has not been studied enough in pregnant or breastfeeding people to know it's safe. Fadogia agrestis has no safety data at all for these periods. Both should be avoided until you talk with your doctor or midwife.
Does this product have any fillers or other ingredients I should know about?
The two active ingredients are Tongkat Ali Root Extract and Fadogia agrestis Stem Extract. It also contains magnesium stearate, rice flour, and gelatin as inactive ingredients—these are standard binders and capsule material.
Should I be concerned about the animal studies showing liver and kidney damage with Fadogia agrestis?
Those concerns come from animal studies; we don't have human safety data for Fadogia agrestis. That's exactly why it should be avoided until we know more, especially in pregnancy and breastfeeding. If you're considering it, talk with your pharmacist about the uncertainty.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fadogia agrestis & Tongkat Ali is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fadogia agrestis & Tongkat Ali label
Go deeper

The Full Monographs Behind Fadogia agrestis & Tongkat Ali’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph →
Sources

Sources & How We Checked

Fadogia agrestis & Tongkat Ali's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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