Fenugreek Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fenugreek against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fenugreek is a dietary supplement by Bixa Botanical with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Trigonella Foenum-graceum extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fenugreek by Bixa Botanical
Ask about any prescription or over-the-counter medication and we check it for interactions with Fenugreek by Bixa Botanical — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fenugreek by Bixa Botanical
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: Fenugreek seed extract (Trigonella Foenum-graceum). The capsule itself is made from HPMC, a vegetarian capsule material.
Does it work?
Moderate evidence
Fenugreek has possibly effective evidence for sexual dysfunction and dysmenorrhea (painful periods). It's also possibly effective for type 2 diabetes — clinical research shows it can lower fasting blood sugar and post-meal blood sugar levels in adults with the condition.
The evidence for these uses comes from clinical studies, though more research may be needed to nail down the details.
How safe is it?
Well-documented data
Fenugreek is generally well tolerated in food amounts, but supplement doses can cause side effects. The most common ones are stomach upset — bloating, gas, diarrhea, nausea, abdominal pain, and indigestion.
Rare but serious reactions include severe allergies with swelling of the throat or difficulty breathing. Fenugreek can also cause allergic skin reactions and, in people inhaling the powder, asthma or fainting.
One odd but harmless side effect: taking fenugreek can give your sweat and urine a distinctive maple-like odor. Don't use medicinal amounts of fenugreek during pregnancy — the safety data advises against it.
While fenugreek is sometimes used to help boost milk supply, the evidence is limited; if you're breastfeeding and want to try it, talk it over with your doctor or pharmacist first.
Meds to double-check
Moderate interaction found
Before taking fenugreek, double-check it with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or clopidogrel), diabetes medications, theophylline, phenytoin (Dilantin), sildenafil (Viagra), or metoprolol (Toprol). Fenugreek may reduce how well these work or raise your bleeding risk.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Fenugreek may help with sexual function, period pain, or blood sugar control if you have type 2 diabetes, but it interacts with blood thinners, diabetes drugs, and several other medications. If you take any prescription drugs — especially for blood clotting, blood sugar, or your heart — check with your doctor or pharmacist before starting it.
It's not safe in medicinal amounts during pregnancy.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fenugreek, straight from the product label.
| Brand | Bixa Botanical |
|---|---|
| Barcode (UPC) | X001AQK59Z |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 228902 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fenugreek by Bixa Botanical, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Trigonella Foenum-graceum extract | 450 mg | -- |
Other ingredients: HPMC Vegetarian Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: This product is not intended for use by those with serious medical condition or pregnant or lactating women. Consult your physician before use.
Keep out of reach of children.
Do not use if seal is broken.
FDA Disclaimer Statement
Disclaimer: These statements have not been evaluated by the Food and Drug Administration and this product is a food supplement and not intended to diagnose treat or cure or prevent any disease.
Seals/Symbols
Halal Mumbai India Halal Committee Registration No. 0854 K LBD (Kosher) Good manufacturing practices GMP
Formulation
Vegan
For sugar & general metabolism
Formula
K LBD (Kosher)
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: 1 capsules 3 times daily after food or as directed by physician
Storage
Store in a cool and dry place.
General Statements
Neutral code: MP/25D/9/89
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fenugreek by Bixa Botanical label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fenugreek by Bixa Botanical
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Trigonella Foenum-graceum extract
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Trigonella Foenum-graceum extract monograph & interactionsOther (inactive) ingredients: HPMC Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.
Fenugreek by Bixa Botanical Drug Interactions
HelloPharmacist Interaction Report
Fenugreek by Bixa Botanical interacts with a number of medications.
The most serious concern involves blood thinners and antiplatelet drugs — through its antiplatelet constituents, fenugreek might add to their effects, raising your bleeding risk. This includes warfarin (Coumadin) and clopidogrel (Plavix), as well as other anticoagulants and antiplatelet drugs more broadly.
Read the full breakdown — every affected drug type, severity by severity
Fenugreek can also lower blood sugar (blood glucose). If you take diabetes medications, adding fenugreek might cause your blood sugar to drop too far.
It may also interfere with theophylline (a medication for breathing problems), phenytoin (Dilantin, a seizure drug), sildenafil (Viagra), and metoprolol (Toprol, a blood pressure and heart medication) — in each case, fenugreek appears to reduce how well these drugs work or how much stays in your bloodstream.
Altogetherr, these interactions span 389 individual medications. If you take any prescription medication — especially blood thinners, diabetes drugs, or heart or seizure medications — use the search tool on this page to check your exact prescriptions before you start fenugreek.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fenugreek?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fenugreek interact with 389 drugs. Click any drug to see the details.
1 of the 1 ingredient in Fenugreek interact with drugs. Each result below shows which ingredient is responsible. Trigonella Foenum-graceum extract
AbciximabReoPro
How Abciximab interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Trigonella Foenum-graceum Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Trigonella Foenum-graceum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Trigonella Foenum-graceum Extract + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fenugreek with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Trigonella Foenum-graceum extract
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Brand information
Manufacturer and brand details for Fenugreek, from the product label.
Bixa Botanical
See all Bixa Botanical products- Name
- Jairamdass Khushiram
- Street Address
- Plot No - M -14/14-1, MIDC, Taloja
- City
- 410 208 Maharasthra
- Phone Number
- 00-91-22-2783 1232
- Web Address
- www.bixabotanical.com
Fenugreek by Bixa Botanical: Common Questions
Does Fenugreek by Bixa Botanical interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take fenugreek if I'm pregnant or breastfeeding?
What are the most common side effects?
Does fenugreek actually work for diabetes?
What is fenugreek used for?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fenugreek is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fenugreek’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Fenugreek's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
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