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Dietary supplement

Lime Peel Ingredients & Drug Interactions

by Bixa Botanical

Lime Peel label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lime Peel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lime Peel is a dietary supplement by Bixa Botanical with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive upset, skin care.Based on those ingredients, 886 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Citrus aurantifolia powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lime Peel by Bixa Botanical

Ask about any prescription or over-the-counter medication and we check it for interactions with Lime Peel by Bixa Botanical — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lime Peel by Bixa Botanical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is just one active ingredient: citrus aurantifolia powder (lime peel). There are no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: skin vitality and general refreshment.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold doesn't establish how well lime works for iron deficiency anemia, malaria, sickle cell disease, or smoking cessation — all five effectiveness ratings are insufficient reliable evidence. In other words, we don't have solid data to say whether it's effective for any of these uses.

The evidence, ingredient by ingredient Lime

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lime as a food is safe for most people. However, concentrated extracts or essential oils are a different story — the safety data for those isn't well studied, so they should be avoided unless your doctor clears them.

Orally, some people have reported diarrhea or tooth sensitivity and wear, though these are rare. Topically, lime oil and juice can cause allergic contact dermatitis and phytophotodermatitis (a skin reaction after sun exposure), so handle it carefully.

Pregnancy and lactation safety data isn't on file for this product — talk with your doctor or pharmacist about whether it's right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Lime

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lime.
  • The most serious interaction on file is rated Moderate.
  • For scale: 887 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bixa Botanical's Lime Peel, double-check with your pharmacist if you're on photosensitizing drugs (medications that increase sun sensitivity) or medications metabolized by the CYP3A4 enzyme, such as sildenafil. Both carry a Moderate risk of interaction.

If you're unsure whether your drugs fall into either category, ask your pharmacist — they can check your medication list against the interactions listed on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lime peel powder is safe when used as a normal food or drink, but this product is a concentrated powder — check with your doctor or pharmacist before taking it, especially if you're on photosensitizing medications or drugs that the liver breaks down via CYP3A4. The evidence doesn't show how well it works for any of the conditions listed.

If you're pregnant, breastfeeding, or on any medications, clear it with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lime Peel, straight from the product label.

Brand Bixa Botanical
Barcode (UPC) 8904289000176
Net contents 200 Gram(s); 7 Ounce(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229584
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lime Peel by Bixa Botanical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
66
UPC/BARCODE
8904289000176
IngredientAmount% DV
Citrus aurantifolia powder3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One- two teaspoon with warm water daily as required or as directed by your health practitioner.

Brand IP Statement(s)

Trademark of Bixa Botanical INC, USA

Formula

Fruit skin powder

K LBD (Kosher)

Formulation

Supports skin vitality & general refreshment

Vegan

Non GMO

FDA Statement of Identity

Herbal Food Supplement

FDA Disclaimer Statement

Disclaimer: These statements have not been evaluated by the Food and Drug Administration and this product is a food supplement and not intended to diagnose treat or cure or prevent any disease.

Precautions

Warning: This product is not intended for use by those with serious medical condition or pregnant or lactating women.

Consult your physician before use.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool and dry place.

General Statements

Product of India

Over 140 years of quality trust

More than a company, Bixa Botanical is a dream- to share the collective knowledge of five generations of a family with the world; secrets of Herbal Healing that have been painstakingly accumulated over over the last 140 years. Over 500 varieties of herbs are exclusively cleaned, processed and packed in the company's ultra-modern in-house facilities.

Mfg. Lic. No : MP25D/14/318

Seals/Symbols

Good manufacturing practices GMP K LBD (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lime Peel by Bixa Botanical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lime Peel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lime Peel by Bixa Botanical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container66 Amounts shown are per serving.

Citrus aurantifolia powder

Interacts with
886 drugs
3 Gram(s) per serving

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people...

Citrus aurantifolia powder monograph & interactions
Interaction report

Lime Peel by Bixa Botanical Drug Interactions

Want to check YOUR meds against Lime Peel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
886Drugs
886 Moderate

Ingredients driving the most interactions

Citrus aurantifolia powder 886

Individual Drug Interactions

The ingredients in Lime Peel interact with 886 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lime Peel interact with drugs. Each result below shows which ingredient is responsible. Citrus aurantifolia powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Lime Peel with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus aurantifolia powder2 drug types · 886 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4. This has been demonstrated in rats treated with sildenafil, a CYP3A4 substrate, and high doses of lime juice.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Likelihood Possible Evidence D
Citrus aurantifolia powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lime Peel, from the product label.

Bixa Botanical

See all Bixa Botanical products
Name
S.A.Herbal Bioactives LLP
Street Address
Plot No: 101, Sector - 1, Pithampur, Dist. Dhar (M.P)
State
454 775
Phone Number
+91 22 2783 1232
Web Address
[email protected]
Pharmacist Counseling Corner

Lime Peel by Bixa Botanical: Common Questions

Does Lime Peel by Bixa Botanical interact with any medications?
Yes. Based on its ingredients, Lime Peel has a known interaction with 886 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lime Peel contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with anemia or malaria?
The evidence we have doesn't tell us one way or the other. We've rated all the effectiveness claims for lime — including iron deficiency anemia, malaria, sickle cell disease, and smoking cessation — as insufficient reliable evidence, which means we don't have solid data yet.
What are the side effects?
Taken by mouth, some people have reported rare diarrhea, tooth sensitivity, or tooth wear. Topically, lime oil and juice can cause allergic skin reactions and phytophotodermatitis (a sun-triggered skin reaction). If you're handling the powder or oil on your skin, wash it off and stay out of the sun.
Is it safe to take while breastfeeding?
We don't have safety data on file for lime during breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What if I'm on blood pressure or heart medications?
Lime can slow how your body breaks down certain medications that your liver processes via the CYP3A4 enzyme. Check with your pharmacist — they can tell you if any of your drugs fall into that group and whether this product is safe for you.
Can I use this if I'm taking acne medications or other sun-sensitizing drugs?
Not without checking first. Lime can raise the risk of phototoxicity — a bad sun sensitivity reaction — if you're on photosensitizing medications. Ask your pharmacist whether your acne medication or any other drugs you take are in that category before you start the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lime Peel is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lime Peel label
Go deeper

The Full Monographs Behind Lime Peel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lime

Interacts with 886 drugs

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people, but evidence that lime treats any spec...

Read the full Lime monograph →
Sources

Sources & How We Checked

Lime Peel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lime 20 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Roesyanto-Mahadi ID, Geursen-Reitsma AM, van Joost T, et al. Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis 1990;22:212-7. PubMed
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
  5. Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
  6. Wagner, A. M., Wu, J. J., Hansen, R. C., Nigg, H. N., and Beiere, R. C. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am.J Contact Dermat. 2002;13(1):10-14. PubMed
  7. Garcia, O. P., Diaz, M., Rosado, J. L., and Allen, L. H. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78(2):267-273. PubMed
  8. Coffman, K., Boyce, W. T., and Hansen, R. C. Phytophotodermatitis simulating child abuse. Am.J Dis.Child 1985;139(3):239-240. PubMed
  9. Adegoke SA, Oyelami OA, Olatunya OS, Adeyemi LA. Effects of lime juice on malaria parasite clearance. Phytother Res. 2011;25(10):1547-50. PubMed
  10. Adegoke SA, Shehu UA, Mohammed LO, Sanusi Y, Oyelami OA. Influence of lime juice on the severity of sickle cell anemia. J Altern Complement Med. 2013;19(6):588-92. PubMed
  11. Assarian Z, Nixon RL. Protein contact dermatitis caused by lime in a pastry chef. Contact Dermatitis. 2015;73(1):54-6. PubMed
  12. Bamise CT, Dinyain VE, Kolawole KA. Dental erosion due to lime consumption; review of literature and case report. East Afr J Public Health. 2009;6(2):141-3. PubMed
  13. Flugman SL. Mexican beer dermatitis: a unique variant of lime phytophotodermatitis attributable to contemporary beer-drinking practices. Arch Dermatol. 2010;146(10):1194-5. PubMed
  14. Galvañ-Pérez Del Pulgar JI, Linares-Barrios M, Galvañ-Pozo JI Jr. Acropigmentation of the dorsum of the hands from preparing mojitos: A lime-induced phytophotodermatosis. Actas Dermosifiliogr. 2016;107(3):253-5. DOI
  15. Hemmerling A, Potts M, Walsh J, Young-Holt B, Whaley K, Stefanski DA. Lime juice as a candidate microbicide? An open-label safety trial of 10% and 20% lime juice used vaginally. J Womens Health (Larchmt). 2007;16(7):1041-51. PubMed
  16. Mauck CK, Ballagh SA, Creinin MD, et al. Six-day randomized safety trial of intravaginal lime juice. J Acquir Immune Defic Syndr. 2008;49(3):243-50. PubMed
  17. Mioduszewski M, Beecker J. Phytophotodermatitis from making sangria: a phototoxic reaction to lime and lemon juice. CMAJ. 2015;187(10):756. PubMed
  18. Rungruanghiranya S, Ekpanyaskul C, Sakulisariyaporn C, Watcharanat P, Akkalakulawas K. Efficacy of fresh lime for smoking cessation. J Med Assoc Thai. 2012;95 Suppl 12:S76-82.
  19. Swerdlin A, Rainey D, Storrs FJ. Fragrance mix reactions and lime allergic contact dermatitis. Dermatitis. 2010;21(4):214-6. DOI
  20. Ademosun AO, Mohammed A, Oboh G, Ajeigbe OF. Influence of lemon (Citrus limon) and lime (Citrus aurantifolia) juices on the erectogenic properties of sildenafil in rats with L-NAME-induced erectile dysfunction. J Food Biochem 2022;46(2):e14074.

See these in context on the Lime monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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