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Dietary supplement

Organic Lime Ingredients & Drug Interactions

by Zongle Therapeutics

Organic Lime label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lime is a dietary supplement by Zongle Therapeutics with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive upset, skin care.Based on those ingredients, 886 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lime. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Lime by Zongle Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lime by Zongle Therapeutics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Organic Lime by Zongle Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lime, provided as a liquid. The inactive ingredients include lime oil (steam-distilled), which serves as an extract or flavoring component.

Lime is a citrus fruit whose juice and oil have traditional uses in food and herbal medicine. In this concentrated liquid form, it's much more potent than lime juice you'd squeeze into water or food.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune system support and stress relief.
  • We looked for evidence on: immune function, stress management, antioxidant support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for lime as a supplement is not established in our data. We hold insufficient reliable evidence to rate its effectiveness for iron deficiency anemia, malaria, sickle cell disease, or smoking cessation.

If you're considering it for a specific health goal, talk with your doctor about whether the science supports it and whether it's right for your situation.

The evidence, ingredient by ingredient Lime

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lime used in normal food and drink amounts is considered safe for most people. However, this is a concentrated liquid product, not food — the safety of concentrated extracts and essential oil products is not well studied.

Our data notes that orally, lime juice may rarely cause diarrhea or tooth sensitivity and wear. Topically, lime oil and juice can cause allergic contact dermatitis in some people, and phytophotodermatitis (a severe skin reaction triggered by sun exposure after lime contact) is common when skin exposure is followed by sun exposure.

Safety in pregnancy and lactation has not been established in our data. Because this is a concentrated product rather than food, talk with your doctor or pharmacist before taking it if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Lime

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lime.
  • The most serious interaction on file is rated Moderate.
  • For scale: 887 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you take photosensitizing drugs (medications that make your skin more sensitive to sun) or any drug that depends on the cytochrome P450 3A4 enzyme to be broken down — a large category that includes many common medications. The interaction is Moderate severity for both.

Use the medication checker on this page to see your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Zongle Therapeutics Organic Lime is a single-ingredient liquid concentrate that may affect how your body handles certain medications, particularly those that rely on a specific liver enzyme (CYP3A4) and drugs that increase sun sensitivity. Evidence for its effectiveness as a supplement is not established.

If you take any prescription medications, check them against this product before starting, and talk with your doctor or pharmacist about whether it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lime, straight from the product label.

Brand Zongle Therapeutics
Barcode (UPC) 856426006382
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276636
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lime by Zongle Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
500
UPC/BARCODE
856426006382
IngredientAmount% DV
Lime60 mg--

Other ingredients: Lime Oil, Steam-Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic, topical or internal use.

For internal use dilute one drop in 4 fl. oz. of liquid. Dilute for kids or sensitive skin.

Formulation

USDA Certified Organic

Fresh and energizing Supports a healthy immune system Helps in relieving stress Purifying and cleaning

Therapeutic Grade

Origin: Sri Lanka Bottled in USA

Certified Organic by GCIAOCP

GMO free Artificial ingredients free Paraben free Pesticide free Preservatives free Gluten free

Vegan

Formula

Adds a fresh citrus flavor

Citrus aurantifolia

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If you are pregnant, nursing, or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas. Avoid sunlight or UV rays for up to 12 hours after applying product.

FDA Statement of Identity

Essential Oil Supplement

Seals/Symbols

USDA Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lime by Zongle Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lime by Zongle Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container500 Amounts shown are per serving.

Lime

Interacts with
886 drugs
60 mg per serving

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people...

Lime monograph & interactions

Other (inactive) ingredients: Lime Oil, Steam-Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lime by Zongle Therapeutics Drug Interactions

Want to check YOUR meds against Organic Lime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
886Drugs
886 Moderate

Ingredients driving the most interactions

Lime 886

Individual Drug Interactions

The ingredients in Organic Lime interact with 886 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lime interact with drugs. Each result below shows which ingredient is responsible. Lime

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lime with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lime2 drug types · 886 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4. This has been demonstrated in rats treated with sildenafil, a CYP3A4 substrate, and high doses of lime juice.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Likelihood Possible Evidence D
Lime full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lime, from the product label.

Zongle Therapeutics

See all Zongle Therapeutics products
Name
Zongle Therapeutics LLC
City
Norcross
State
GA
ZipCode
30093
Web Address
www.zongletherapeutics.com
Pharmacist Counseling Corner

Organic Lime by Zongle Therapeutics: Common Questions

Does Organic Lime by Zongle Therapeutics interact with any medications?
Yes. Based on its ingredients, Organic Lime has a known interaction with 886 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lime contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this just regular lime juice, or something different?
No — this is a concentrated liquid product, not fresh lime juice. The safety data for concentrated lime extract and essential oil is not as well studied as it is for lime as food. That's why our safety notes advise against concentrated products unless your doctor clears it.
Can I use this if I take other medications?
That depends on what you take. Lime may slow how your liver breaks down certain drugs and may increase the risk of sun sensitivity reactions if you're on photosensitizing medications. Use the medication checker on this page to see if any of your drugs are affected, and then talk it over with your doctor or pharmacist.
What's inside — is there anything else in here?
The active ingredient is lime. There is one inactive ingredient: steam-distilled lime oil, which is part of the extract.
Are there any side effects I should know about?
Orally, diarrhea and tooth sensitivity are rare but possible. If you apply lime topically, allergic skin reactions can happen, and sun exposure after skin contact can cause a severe burn-like reaction called phytophotodermatitis. Because this is a concentrated product, side effects may be more likely than with food.
Is it safe to use while pregnant or breastfeeding?
We don't have enough data on this concentrated product to say either way. Talk with your doctor or pharmacist before taking it during pregnancy or while breastfeeding — they can help you decide based on your situation.
Does it actually work for anything?
We don't have reliable evidence that lime supplements work for iron deficiency anemia, malaria, sickle cell disease, or smoking cessation. If you're thinking about it for a specific reason, ask your doctor whether the science backs it up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lime label
Go deeper

The Full Monographs Behind Organic Lime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lime

Interacts with 886 drugs

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people, but evidence that lime treats any spec...

Read the full Lime monograph →
Sources

Sources & How We Checked

Organic Lime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lime 20 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Roesyanto-Mahadi ID, Geursen-Reitsma AM, van Joost T, et al. Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis 1990;22:212-7. PubMed
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
  5. Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
  6. Wagner, A. M., Wu, J. J., Hansen, R. C., Nigg, H. N., and Beiere, R. C. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am.J Contact Dermat. 2002;13(1):10-14. PubMed
  7. Garcia, O. P., Diaz, M., Rosado, J. L., and Allen, L. H. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78(2):267-273. PubMed
  8. Coffman, K., Boyce, W. T., and Hansen, R. C. Phytophotodermatitis simulating child abuse. Am.J Dis.Child 1985;139(3):239-240. PubMed
  9. Adegoke SA, Oyelami OA, Olatunya OS, Adeyemi LA. Effects of lime juice on malaria parasite clearance. Phytother Res. 2011;25(10):1547-50. PubMed
  10. Adegoke SA, Shehu UA, Mohammed LO, Sanusi Y, Oyelami OA. Influence of lime juice on the severity of sickle cell anemia. J Altern Complement Med. 2013;19(6):588-92. PubMed
  11. Assarian Z, Nixon RL. Protein contact dermatitis caused by lime in a pastry chef. Contact Dermatitis. 2015;73(1):54-6. PubMed
  12. Bamise CT, Dinyain VE, Kolawole KA. Dental erosion due to lime consumption; review of literature and case report. East Afr J Public Health. 2009;6(2):141-3. PubMed
  13. Flugman SL. Mexican beer dermatitis: a unique variant of lime phytophotodermatitis attributable to contemporary beer-drinking practices. Arch Dermatol. 2010;146(10):1194-5. PubMed
  14. Galvañ-Pérez Del Pulgar JI, Linares-Barrios M, Galvañ-Pozo JI Jr. Acropigmentation of the dorsum of the hands from preparing mojitos: A lime-induced phytophotodermatosis. Actas Dermosifiliogr. 2016;107(3):253-5. DOI
  15. Hemmerling A, Potts M, Walsh J, Young-Holt B, Whaley K, Stefanski DA. Lime juice as a candidate microbicide? An open-label safety trial of 10% and 20% lime juice used vaginally. J Womens Health (Larchmt). 2007;16(7):1041-51. PubMed
  16. Mauck CK, Ballagh SA, Creinin MD, et al. Six-day randomized safety trial of intravaginal lime juice. J Acquir Immune Defic Syndr. 2008;49(3):243-50. PubMed
  17. Mioduszewski M, Beecker J. Phytophotodermatitis from making sangria: a phototoxic reaction to lime and lemon juice. CMAJ. 2015;187(10):756. PubMed
  18. Rungruanghiranya S, Ekpanyaskul C, Sakulisariyaporn C, Watcharanat P, Akkalakulawas K. Efficacy of fresh lime for smoking cessation. J Med Assoc Thai. 2012;95 Suppl 12:S76-82.
  19. Swerdlin A, Rainey D, Storrs FJ. Fragrance mix reactions and lime allergic contact dermatitis. Dermatitis. 2010;21(4):214-6. DOI
  20. Ademosun AO, Mohammed A, Oboh G, Ajeigbe OF. Influence of lemon (Citrus limon) and lime (Citrus aurantifolia) juices on the erectogenic properties of sildenafil in rats with L-NAME-induced erectile dysfunction. J Food Biochem 2022;46(2):e14074.

See these in context on the Lime monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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