Drug & supplement interaction

Lime + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine brand name: Norel Plus.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine falls into 2 drug categories that Lime can interact with; the most serious is rated moderate. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lime and Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Lime interacts with whole categories of medication. Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine falls into 2 of those categories, so it can interact with Lime in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

PHOTOSENSITIZING DRUGS

1 of 2

Why this applies to Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine falls under PHOTOSENSITIZING DRUGS — the group Lime interacts with.

Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Norel Plus (a combo of acetaminophen, chlorpheniramine, phenylpropanolamine, and phenyltoloxamine) with lime: this isn't about how your body breaks the medicine down. The concern is sun sensitivity. Some of these ingredients can occasionally make your skin more reactive to sunlight, and lime oil contains compounds (like those in the peel) that can do the same. Put them together and, in theory, you could sunburn or get a skin rash more easily.

I want to be honest about how soft this evidence is. It comes from lab and animal studies, not real patients, and it really applies to concentrated lime oil on the skin, not a squeeze of lime in your food or drink. Culinary lime almost certainly won't matter. If you're using lime essential oil and spending time in the sun, just chat with your pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

2 of 2

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4. This has been demonstrated in rats treated with sildenafil, a CYP3A4 substrate, and high doses of lime juice.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo pill (Norel Plus) packs several active ingredients, and some of them are partly broken down by a liver enzyme called CYP3A4. The concern on file is that compounds in lime may slow that enzyme down. In theory, that could let parts of this medicine linger a bit longer, which might bump up familiar side effects like drowsiness, dry mouth, dizziness, or a jittery, racing-heart feeling from the decongestant piece.

Here's the reassuring part: this finding comes only from animal studies using high doses of lime juice, not from people. A squeeze of lime on your food or in a drink is very unlikely to cause a problem. If you're thinking about concentrated lime supplements or large daily amounts, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
  2. Ademosun AO, Mohammed A, Oboh G, Ajeigbe OF. Influence of lemon (Citrus limon) and lime (Citrus aurantifolia) juices on the erectogenic properties of sildenafil in rats with L-NAME-induced erectile dysfunction. J Food Biochem 2022;46(2):e14074.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lime Also Interacts With Other Medications

Lime has 887 moderate known drug interactions in our database — the Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine one above is among them. If you take anything else, check it against the full list below.

Moderate 887 No known interaction 1,943 (incl. Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine)
Taking anything else?

Check Another of Your Medications Against Lime

Covers the 2,830 medications we’ve checked against Lime. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine

This page covers Lime only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine page lists 292 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).

By severity: 14 major · 232 moderate · 46 minor.

Open the Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction page

One more smart check

Taking Lime as Part of a Dietary Supplement Product? Check It for Interactions

We hold 322 real supplement products containing Lime, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lime. Your product may carry other ingredients that interact with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine too, on top of Lime — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lime and Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lime
Top 25%

#312 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine
Top 25%

#700 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lime

What is Lime?

Lime
  • Source of vitamin C
  • Digestive upset
  • Skin care
  • Mood and aromatherapy
  • Flavoring and food preservation

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people, but evidence that lime treats any specific health condition is limited. Use the essential oil with care, and check with your pharmacist or doctor before using concentrated lime products for health reasons.

Read the full Lime monograph & all interactions
Keep checking

Other Drugs & Lime

Browse every other medication we’ve checked against Lime — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
887Moderate
0Minor
1,942No known interaction
887 Moderate 1,942 No interaction
Moderate

887 interactions

Showing 60 of 887 moderate interactions — see all 887 on the Lime page.

No interaction 1,942 drugs checked — show the list

We also checked Lime against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,942 medications checked with no known interaction — see the full Lime list.

See the full Lime interactions page
See every supplement checked against Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lime monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine supplement interactions › Every supplement checked against Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lime and Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine Together: Common Questions

Can you take Lime with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Lime and Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine?
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine belongs to more than one drug category, and Lime interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Lime and Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine and Lime?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.