Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Fish Oil +Krill Ingredients & Drug Interactions

by GNC Triple Strength

Fish Oil +Krill label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fish Oil +Krill against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fish Oil +Krill is a dietary supplement by GNC Triple Strength with 3 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neptune Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fish Oil +Krill by GNC Triple Strength

Ask about any prescription or over-the-counter medication and we check it for interactions with Fish Oil +Krill by GNC Triple Strength — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fish Oil +Krill by GNC Triple Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GNC Triple Strength Fish Oil + Krill gives you three active ingredients: eicosapentaenoic acid and docosahexaenoic acid (both omega-3 fatty acids from fish) and Neptune Krill Oil. The product also contains fish body oil, soybean oil, gelatin, glycerin, and an enteric coating (an inactive shell that helps the softgel survive stomach acid without releasing its contents too early).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Krill Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Hypertriglyceridemia, Hyperlipidemia, Osteoarthritis, Rheumatoid arthritis (RA) — and 3 related terms.
  • The closest evidence on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Hypertriglyceridemia, Osteoarthritis, and more.

The evidence is mixed. Krill oil is possibly effective for dry eye — meaning some research supports it, though more testing would strengthen the claim.

For aging skin, Alzheimer's disease, cancer prevention, high cholesterol (hyperlipidemia), and cognitive function, we don't have enough reliable evidence to say whether it works. If dry eye is your main reason for considering this product, talk with your eye care provider about whether it's the right choice for you.

The evidence, ingredient by ingredient Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated in doses up to 4 grams daily. The most common side effects are digestive — bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort.

Headache, tiredness, and dizziness have been reported rarely. Importantly, avoid this product if you have a shellfish allergy, and use caution if you have a bleeding disorder.

During pregnancy and breastfeeding, there isn't enough reliable safety data — talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — krill oil may increase bleeding risk. Also flag any diabetes medications, since krill oil might lower blood sugar.

We couldn't fully check the two omega-3 fatty acids in this product, so mention those to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with dry eye, but evidence for other uses is thin. If you take blood thinners or diabetes medication, check with your doctor or pharmacist before starting — krill oil could raise your bleeding risk or lower your blood sugar.

The omega-3 ingredients we couldn't fully check add another reason to confirm it's safe for your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fish Oil +Krill, straight from the product label.

Brand GNC Triple Strength
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1073
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fish Oil +Krill by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Calories20 {Calories}--
Calories from Fat20 {Calories}--
Total Fat2 g3%
Eicosapentaenoic Acid647 mg--
Docosahexaenoic Acid253 mg--
Cholesterol5 mg2%
Neptune Krill Oil300 mg--

Other ingredients: Fish Body Oil, Soybean Oil, Gelatin, Glycerin, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

• 900 mg of total omega-3 fatty acids • 300 mg of Neptune Krill Oil with enhanced omega absorption • Clinically proven to promote joint and heart health^* • Provides enhanced antioxidant protection*

CONTAINS: Crustaceans (Krill).

Formulation

No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Corn, No Dairy, Yeast Free.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place.

General Statements

^In a randomized, double-blind, placebo controlled clinical study, 87 volunteers were supplemented with either 300 mg of Neptune Krill Oil or placebo. After 30 days, subjects receiving Neptune Krill Oil had a significant decrease in CRP, a biomarker for heart and joint health, as well as significant improvements in joint comfort, joint function and stiffness.

• Provides critical antioxidants like astaxanthin with higher antioxidant activity than other popular antioxidants to combat harmful free radicals associated with cell-aging.*

ACTUAL SIZE

Blended with 100% Pure Neptune Krill Oil - Neptune Krill Oil is manufactured by NEPTUNE TECHNOLOGIES & BIORESSOURCES

Conforms to USP <2091> for weight.

Enteric Coated

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

GNC Triple Strength Fish Oil plus Krill combines 300 mg of clinically proven Neptune Krill Oil with Triple Strength Fish Oil providing 900 mg of the omega-3 fatty acids EPA and DHA. These essential fatty acids support normal, healthy cholesterol levels and are necessary for heart health and the maintenance of normal, healthy blood pressure.* Plus, EPA and DHA support healthy joints and skin and promote optimal eye and brain function.* Neptune Krill Oil Benefits: • Delivers superior bioavailability of the omega-3 fatty acids, EPA and DHA, compared to other omega-3 sources. These omega-3 fatty acids are uniquely bound to phospholipids, enhancing their absorption. • Fast-acting, clinically proven to improve joint comfort and function.^ · Clinically proven to reduce C-Reactive Protein (CRP) levels by 30%, a key marker of joint and heart health.^

Krill are tiny crustaceans that live in the cold waters of the Antarctic. The fish oil in GNC Triple Strength Fish Oil plus Krill has been purified and manufactured for freshness and found to be free of detectable levels of mercury, cadmium, lead and PCBs.

Neptune Krill Oil is Clinically Proven to Reduce C-Reactive Protein (CRP) Levels by 30%. A Key Marker of Joint and Heart Health^

Please recycle this box.

Potency verified by GNC procedure #5123.

The enteric coating controls or reduces fishy burps by allowing the softgel capsule to break down and absorb in the small intestine.

Triple Strength Fish Oil Benefits: • Delivers a high potency of 900 mg of the omega-3 fatty acids, EPA and DHA. · A landmark study involving over 11,000 participants has confirmed the major benefits of fish oil on cardiovascular health.*

General

CODE 886211 AMG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two softgel capsules daily with food.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fish Oil +Krill by GNC Triple Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fish Oil +Krill label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fish Oil +Krill by GNC Triple Strength

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

647 mg per serving

Docosahexaenoic Acid

253 mg per serving

Neptune Krill Oil

Interacts with
208 drugs
300 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Neptune Krill Oil monograph & interactions

Other (inactive) ingredients: Fish Body Oil, Soybean Oil, Gelatin, Glycerin, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fish Oil +Krill by GNC Triple Strength Drug Interactions

Want to check YOUR meds against Fish Oil +Krill?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Neptune Krill Oil 208

Individual Drug Interactions

The ingredients in Fish Oil +Krill interact with 208 drugs. Click any drug to see the details.

1 of the 3 ingredients in Fish Oil +Krill interact with drugs. Each result below shows which ingredient is responsible. Neptune Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Fish Oil +Krill with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neptune Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Neptune Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fish Oil +Krill, from the product label.

GNC Triple Strength

See all GNC Triple Strength products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Fish Oil +Krill by GNC Triple Strength: Common Questions

Does Fish Oil +Krill by GNC Triple Strength interact with any medications?
Yes. Based on its ingredients, Fish Oil +Krill has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fish Oil +Krill contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me fish burps?
It's possible — fishy burps are among the most common side effects reported. Other digestive effects include bloating, gas, heartburn, and nausea. The good news is these tend to be milder or happen less often with krill oil than with regular fish oil.
Is it safe if I'm allergic to shellfish?
No — you should avoid it. Krill comes from the ocean and contains shellfish proteins, so if you have a shellfish allergy, this product isn't for you.
Can I take it while I'm pregnant?
There isn't enough reliable safety data to say yes or no. Talk with your doctor before using it during pregnancy — they can weigh the potential benefits against any risks specific to your situation.
What is krill oil actually used for?
Krill oil is possibly effective for dry eye. For other uses mentioned — aging skin, brain health, cholesterol, and cancer prevention — the evidence isn't strong enough yet to say whether it works.
How much krill oil is in each capsule?
The product facts don't specify the amount per capsule, but studies show krill oil is generally well tolerated at doses up to 4 grams daily. Check the label or contact GNC for the exact dose in your softgels.
Is this product really free of fillers?
No — it contains several inactive ingredients including fish body oil, soybean oil, gelatin, glycerin, and an enteric coating. These are standard excipients that help make and protect the softgel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fish Oil +Krill is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fish Oil +Krill label
Go deeper

The Full Monographs Behind Fish Oil +Krill’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Fish Oil +Krill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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