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Dietary supplement

Flax Seed Oil 1000 mg Ingredients & Drug Interactions

by Protocol For Life Balance

Flax Seed Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flax Seed Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flax Seed Oil 1000 mg is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flaxseed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flax Seed Oil 1000 mg by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with Flax Seed Oil 1000 mg by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flax Seed Oil 1000 mg by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients. Flaxseed oil is the main active ingredient, a plant-based oil rich in omega-3 fatty acids.

The product also contains polyunsaturated fat and monounsaturated fat, which are types of dietary fats found naturally in flaxseed. The softgel capsule itself is made from bovine gelatin, glycerin, water, and caramel color — these are inactive ingredients that help deliver the oil.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Flaxseed Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy immune system and cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Atherosclerosis, Dry skin, cholesterol management — and 2 related terms.
  • The closest evidence on file: Flaxseed Oil is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Flaxseed Oil is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Dry skin, Hypertension.

The evidence for flaxseed oil is mixed and generally weak across the conditions studied. Our data rates it possibly ineffective for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol (hyperlipidemia).

That means the clinical trials we have don't show it works for these conditions — though it doesn't rule out a benefit you might experience personally. If you're considering it for a specific health reason, talk with your pharmacist or doctor about what the evidence actually supports.

The evidence, ingredient by ingredient Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Flaxseed oil is generally well tolerated when taken by mouth. A small number of people reported mild side effects like changes in bowel habits, dry mouth, or stomach upset at doses around 5 grams daily.

High doses of 30 grams per day or higher have been linked to loose stools and diarrhea. Rare serious allergic reactions like anaphylaxis are possible but uncommon.

Safety data during pregnancy is not on file for this ingredient. For breastfeeding, there's limited safety information, so medical advice is needed before use.

Because overall safety data is not robust, it's best to check with your doctor before starting.

Side effects, ingredient by ingredient Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — there's a moderate risk of increased bleeding. Also flag it if you take blood pressure medication, since flaxseed oil may add to their effect.

And if you're on ezetimibe (Zetia), let us know, as it reduces how much of flaxseed oil's active ingredient your body absorbs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Flaxseed oil may be worth considering if you're looking for an omega-3 supplement, but the evidence for its effectiveness in treating specific conditions is weak. If you take blood thinners, blood pressure medication, or ezetimibe (Zetia), you'll need to check with your pharmacist first — this product can interact with those drugs.

Talk to your pharmacist before you start, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flax Seed Oil 1000 mg, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359117709
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326436
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flax Seed Oil 1000 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
UPC/BARCODE
707359117709
IngredientAmount% DV
Calories25 Calorie(s)--
Total Fat3 Gram(s)4%
Saturated Fat0.5 Gram(s)2%
Polyunsaturated Fat2 Gram(s)--
Monounsaturated Fat0.5 Gram(s)--
Flaxseed Oil3000 mg--

Other ingredients: Bovine Gelatin, Glycerin, Water, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 3 softgels daily with a meal, or as directed by your healthcare practitioner.

Formula

How it works: Flax seed oil has an abundance of alpha-linolenic acid, an omega-3 fatty acid that can be converted into eicosapentaenoic acid (EPA). Omega-3 fatty acids are essential nutrients that are poorly represented in the modern diet.

Made with organic flax oil

Each serving may also have the following naturally occurring amounts of polyunsaturated fats and monounsaturated fats: Linolenic Acid (Omega-3 55%; Linolenic Acid (Omega-6) 14%; Oleic Acid (Omega-9) 19%; Other (Saturated) 12%

Formulation

These important fatty acids help to support a healthy and balanced immune system, are important for cardiovascular health, and promote the maintenance of healthy skin. This flax seed oil has been cold pressed to be as close to the original seed oil composition as possible. Care has been taken to bring this product to market in softgels, a delivery form that hermetically seals the oil and protects it from oxidation and contamination.

No preservatives, additives, bleaches or fillers are used with this oil.

Supports cardiovascular health

Non-GMO

Certified organic by QAI

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

Precautions

Cautions/Interactions: Flax seed oil is generally well tolerated, but has been associated with mild gastric disturbances.

Some evidence suggests that flaxseed may moderately interact with anti-coagulant and estrogen medications.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flax Seed Oil 1000 mg by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flax Seed Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flax Seed Oil 1000 mg by Protocol For Life Balance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Flaxseed Oil

Interacts with
293 drugs
3000 mg per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Flaxseed Oil monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Glycerin, Water, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flax Seed Oil 1000 mg by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against Flax Seed Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Flaxseed Oil 293

Individual Drug Interactions

The ingredients in Flax Seed Oil 1000 mg interact with 293 drugs. Click any drug to see the details.

1 of the 1 ingredient in Flax Seed Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Flaxseed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Flax Seed Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
Flaxseed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flax Seed Oil 1000 mg, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
protocolforlife.com
Pharmacist Counseling Corner

Flax Seed Oil 1000 mg by Protocol For Life Balance: Common Questions

Does Flax Seed Oil 1000 mg by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, Flax Seed Oil 1000 mg has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flax Seed Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will flaxseed oil lower my cholesterol?
Our data rates flaxseed oil possibly ineffective for high cholesterol. The clinical trials we have don't show it works for that — though that doesn't mean it won't help you personally. Your doctor or pharmacist can give you a clearer picture based on your own situation.
What are the most common side effects?
When taken by mouth, a small number of people reported mild side effects like changes in bowel habits, dry mouth, or stomach upset. High doses (30 grams daily or more) are more likely to cause loose stools and diarrhea. Most people tolerate it fine at normal doses.
Is it safe to take while breastfeeding?
We don't have enough safety data on flaxseed oil during breastfeeding to say either way. You'll need to talk with your doctor or pharmacist for personalized advice before you start.
Can I take this with my blood thinner?
You need to check with your pharmacist first. Flaxseed oil may increase bleeding risk when combined with blood thinners like warfarin or antiplatelet drugs like aspirin, so you shouldn't add it without medical clearance.
Does this product have any fillers?
Yes. The softgel capsule contains bovine gelatin, glycerin, water, and caramel color as inactive ingredients to make the oil easier to take.
What is alpha-linolenic acid and why does it matter?
Alpha-linolenic acid is a type of omega-3 fatty acid found in flaxseed oil. It's why flaxseed is sometimes taken as a supplement — but if you take ezetimibe (Zetia), that medication blocks your body from absorbing it, so the product won't work as intended.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flax Seed Oil 1000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flax Seed Oil 1000 mg label
Go deeper

The Full Monographs Behind Flax Seed Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

Flax Seed Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Flaxseed Oil 21 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed
  16. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
  18. Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
  19. Jamilian M, Tabassi Z, Reiner Z, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020;123(7):792-799
  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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