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Dietary supplement

Flaxseed Oil 1,000 mg Ingredients & Drug Interactions

by Natural Nutra

Flaxseed Oil 1,000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flaxseed Oil 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flaxseed Oil 1,000 mg is a dietary supplement by Natural Nutra with 2 active ingredients. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Flaxseed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flaxseed Oil 1,000 mg by Natural Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with Flaxseed Oil 1,000 mg by Natural Nutra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flaxseed Oil 1,000 mg by Natural Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic flaxseed oil at 1,000 mg per softgel capsule. Flaxseed oil is derived from flax seeds and is a source of alpha-linolenic acid, an omega-3 fatty acid.

The capsule itself, along with glycerin and purified water, are inactive ingredients that help deliver and stabilize the oil.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Flaxseed Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintain healthy skin, joints and cell membrane structure.
  • We looked for evidence on: Dry skin, Rheumatoid arthritis (RA), joint health, skin barrier function, inflammation.
  • The closest evidence on file: Flaxseed Oil is rated "Possibly Ineffective" for Rheumatoid arthritis (RA) (Natural Medicines).
  • Also on file: Flaxseed Oil is rated "Insufficient Reliable Evidence To Rate" for Dry skin.

The evidence we have for flaxseed oil in the conditions studied is limited. It's rated possibly ineffective for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol (hyperlipidemia).

This means the clinical trials we reviewed don't show it working well for these uses, though more research could change that picture.

The evidence, ingredient by ingredient Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Flaxseed oil is generally well tolerated when taken by mouth. A small number of people — roughly 3% — reported loose stools, dry mouth, or indigestion at doses around 5 grams daily.

Rare but serious allergic reactions like anaphylaxis have been reported. High doses (30 grams a day and higher) are more likely to cause loose stools or diarrhea.

There isn't enough reliable safety data overall, so check with your doctor before starting, especially if you're pregnant, breastfeeding, or have a history of allergic reactions to flax.

Side effects, ingredient by ingredient Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners (like warfarin, aspirin, or clopidogrel) — flaxseed oil may increase bleeding risk. Also flag it if you take any blood pressure medication, since flaxseed oil can lower pressure on its own.

And mention it if you're on ezetimibe (Zetia), because the two don't work well together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Flaxseed oil is most appropriate for people interested in omega-3 supplementation who are not taking blood thinners or blood pressure medications. If you do take either type of drug, or if you're on ezetimibe, talk it over with your doctor or pharmacist first — they'll help you decide if it's right for you and whether you need to adjust anything.

The evidence doesn't support its use for obesity, arthritis, bipolar disorder, or high cholesterol.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flaxseed Oil 1,000 mg, straight from the product label.

Brand Natural Nutra
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246947
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flaxseed Oil 1,000 mg by Natural Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
IngredientAmount% DV
Total Fat1 Gram(s)1%
Total Calories10 Calorie(s)--
organic Flaxseed Oil1000 mg--

Other ingredients: Capsule, Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Typical Fatty Acid composition: Alpha-Linolenic Acid (ALA) 440 mg Linoleic Acid (LA) 120 mg Oleic Acid 142 mg

To report a serious adverse event, call 1-888-710-0006

Suggested/Recommended/Usage/Directions

Suggested Use: Take one softgel up to six times daily.

Formulation

Contains no artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.

The flax seeds in this product do not contain conventional pesticides, synthetic fertilizers, growth hormones, genetic modification or antibiotics. SGS verified the process of manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo

Purity + potency guaranteed

Cold-pressed and hexane-free

Gluten free Non GMO

This product is certified organic by Quality Assurance International (QAI).

Cold-pressed and hexane-free

Made with organic flaxseeds

Formula

Flaxseed oil is nature's richest vegetarian source of the essential fatty acids, ALA (omega-3) and LA (omega-6). These fatty acids produce prostaglandins that help maintain healthy skin, joints and cell membrane structure as well as promote cardiovascular and nervous system health. Our Flaxseed Oil is made from organic flax seeds and is cold pressed, unfiltered, unbleached and free of hexane.

Made with organic flaxseeds

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Quality Assurance International Certified Organic

FDA Statement of Identity

Dietary Supplement

Precautions

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flaxseed Oil 1,000 mg by Natural Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flaxseed Oil 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flaxseed Oil 1,000 mg by Natural Nutra

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Calories

10 Calorie(s) per serving

Organic Flaxseed Oil

Interacts with
293 drugs
1000 mg per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Organic Flaxseed Oil monograph & interactions

Other (inactive) ingredients: Capsule, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flaxseed Oil 1,000 mg by Natural Nutra Drug Interactions

Want to check YOUR meds against Flaxseed Oil 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

organic Flaxseed Oil 293

Individual Drug Interactions

The ingredients in Flaxseed Oil 1,000 mg interact with 293 drugs. Click any drug to see the details.

1 of the 2 ingredients in Flaxseed Oil 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. organic Flaxseed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Flaxseed Oil 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
organic Flaxseed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flaxseed Oil 1,000 mg, from the product label.

Natural Nutra

See all Natural Nutra products
Name
Hurd Dynamics LLC, DBA Natural Nutra
City
Tampa
State
FL
ZipCode
33615
Phone Number
1-888-710-0006
Web Address
www.natnutra.com
Pharmacist Counseling Corner

Flaxseed Oil 1,000 mg by Natural Nutra: Common Questions

Does Flaxseed Oil 1,000 mg by Natural Nutra interact with any medications?
Yes. Based on its ingredients, Flaxseed Oil 1,000 mg has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flaxseed Oil 1,000 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take flaxseed oil if I'm pregnant?
The data we hold rates flaxseed oil as possibly safe in pregnancy, but there isn't enough reliable safety information to know for sure. Talk with your doctor or pharmacist about whether it's right for you and your pregnancy.
Is it safe to take while breastfeeding?
There's limited safety information during breastfeeding, so use it only with medical advice. Check with your doctor or pharmacist before starting.
What side effects might I notice?
Most people tolerate it well. A small number report loose stools, dry mouth, or indigestion at typical doses. High doses (30 grams daily and higher) are more likely to cause loose stools or diarrhea. Severe allergic reactions are rare but possible.
Will flaxseed oil help my high cholesterol?
The evidence we have rates it as possibly ineffective for high cholesterol. The clinical trials we reviewed didn't show it working well for this purpose.
What is alpha-linolenic acid, and why does it matter?
Alpha-linolenic acid (ALA) is an omega-3 fatty acid found in flaxseed oil. Your body can convert it to other omega-3s, which is why flaxseed is often used as a plant-based source of these fats. If you take ezetimibe, though, that drug blocks your body from absorbing ALA from flaxseed oil.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flaxseed Oil 1,000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flaxseed Oil 1,000 mg label
Go deeper

The Full Monographs Behind Flaxseed Oil 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

Flaxseed Oil 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Flaxseed Oil 21 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed
  16. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
  18. Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
  19. Jamilian M, Tabassi Z, Reiner Z, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020;123(7):792-799
  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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