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Dietary supplement

Flaxseed Oil Softgels Ingredients & Drug Interactions

by ON Optimum Nutrition

Flaxseed Oil Softgels label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flaxseed Oil Softgels against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flaxseed Oil Softgels is a dietary supplement by ON Optimum Nutrition with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flaxseed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flaxseed Oil Softgels by ON Optimum Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Flaxseed Oil Softgels by ON Optimum Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flaxseed Oil Softgels by ON Optimum Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel has 2 active ingredients: polyunsaturated fat and flaxseed oil, which provides omega-3 fatty acids. The softgel shell and fillings are made from gelatin, glycerin, and caramel color.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Flaxseed Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cardiovascular and nervous system health support.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Heart health, Cholesterol management — and 1 related terms.
  • The closest evidence on file: Flaxseed Oil is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Flaxseed Oil is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hypertension.

The evidence for flaxseed oil's effectiveness is limited. Research shows it may be ineffective for obesity, high cholesterol (hyperlipidemia), rheumatoid arthritis, and bipolar disorder — meaning available studies do not support its use for these conditions.

The evidence, ingredient by ingredient Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Flaxseed oil is generally well tolerated when taken by mouth. A small number of users report mild side effects like changes in bowel habits, dry mouth, or indigestion at typical doses around 5 grams daily.

Very high doses (30 grams or more per day) have been linked to loose stools and diarrhea. Severe allergic reactions like anaphylaxis are rare.

Safety data during pregnancy and breastfeeding is limited, so talk with your doctor before using this product if you are pregnant or nursing.

Side effects, ingredient by ingredient Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use blood pressure medications (antihypertensive drugs), blood thinners or antiplatelet drugs, or ezetimibe (Zetia). All three drug types interact at Moderate severity with flaxseed oil.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This flaxseed oil product is generally well tolerated and is possibly safe in pregnancy, but the evidence for its effectiveness is weak. Its main concern is that it may increase bleeding risk or lower blood pressure when combined with certain medications.

If you take blood pressure drugs, blood thinners, or ezetimibe, check with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flaxseed Oil Softgels, straight from the product label.

Brand ON Optimum Nutrition
Barcode (UPC) 748927027204
Net contents 200 Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25923
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flaxseed Oil Softgels by ON Optimum Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
200
UPC/BARCODE
748927027204
IngredientAmount% DV
Calories10 {Calories}--
Calories from Fat10 {Calories}--
Polyunsaturated Fat0.5 Gram(s)--
Total Fat1 Gram(s)2%
Flaxseed Oil1000 mg--

Other ingredients: Gelatin, Glycerin, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN. CHECK WITH A QUALIFIED HEALTHCARE PROFESSIONAL BEFORE USING THIS PRODUCT IF YOU ARE UNDER 18 YEARS OF AGE, PREGNANT OR NURSING A BABY OR IF YOU HAVE ANY KNOWN OR SUSPECTED MEDICAL CONDITION(S) AND/OR ARE TAKING ANY PRESCRIPTION OR OTC MEDICATION(S).

CHECK WITH A QUALIFIED HEALTHCARE PROFESSIONAL BEFORE USING THIS PRODUCT IF YOU ARE UNDER 18 YEARS OF AGE, PREGNANT OR NURSING A BABY OR IF YOU HAVE ANY KNOWN OR SUSPECTED MEDICAL CONDITION(S) AND/OR ARE TAKING ANY PRESCRIPTION OR OTC MEDICATION(S).

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Brand IP Statement(s)

THE BIGGER PICTURE(TM)

(C)2007 OPTIMUM NUTRITION, INC

General Statements

1,000 MG COLD-PRESSED

THE BIGGER PICTURE OF FLAXSEED OIL Flaxseeds are one of nature's richest plant sources of omega-3 fatty acids. Omega-3 fats are essential (your body can't synthesize them) and help support optimal functioning of the cardiovascular, nervous, and immune systems.

TYPICAL FATTY ACID PROFILE (milligrams per softgel) Alpha-Linolenic Acid (Omega 3) 450 mg Linoleic Acid (Omega 6) 110 mg Oleic Acid (Omega 9) 110 mg

Seals/Symbols

ON(TM)

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, take 1-3 softgels daily with meals.

Formula

Our Flaxseed Oil Softgels deliver 1000 miligrams of pure flaxseed oil packed with alpha-linoleic acid (ALA). They're also prepared using cold-extraction techniques to better preserve the delicate components and ensure that you get all the benefits, including a healthy dose of valuable linoleic (omega-6) and oleic (omega-9) fatty acids, in every serving.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flaxseed Oil Softgels by ON Optimum Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flaxseed Oil Softgels label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flaxseed Oil Softgels by ON Optimum Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container200 Amounts shown are per serving.

Flaxseed Oil

Interacts with
293 drugs
1000 mg per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Flaxseed Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flaxseed Oil Softgels by ON Optimum Nutrition Drug Interactions

Want to check YOUR meds against Flaxseed Oil Softgels?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Flaxseed Oil 293

Individual Drug Interactions

The ingredients in Flaxseed Oil Softgels interact with 293 drugs. Click any drug to see the details.

1 of the 1 ingredient in Flaxseed Oil Softgels interact with drugs. Each result below shows which ingredient is responsible. Flaxseed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Flaxseed Oil Softgels with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
Flaxseed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flaxseed Oil Softgels, from the product label.

ON Optimum Nutrition

See all ON Optimum Nutrition products
Name
ON(TM)
City
Sunrise
State
FL
ZipCode
33325
Pharmacist Counseling Corner

Flaxseed Oil Softgels by ON Optimum Nutrition: Common Questions

Does Flaxseed Oil Softgels by ON Optimum Nutrition interact with any medications?
Yes. Based on its ingredients, Flaxseed Oil Softgels has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flaxseed Oil Softgels contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is flaxseed oil safe to take while pregnant?
Flaxseed oil is rated possibly safe in pregnancy, but the safety data is limited. You'll want to talk with your doctor before starting it to make sure it's right for your situation.
What are the most common side effects?
Flaxseed oil is generally well tolerated. A small number of users report changes in bowel habits, dry mouth, or indigestion at normal doses. High doses (30 grams or more daily) may cause loose stools or diarrhea.
Can flaxseed oil help with high cholesterol?
Research suggests flaxseed oil is possibly ineffective for high cholesterol. The available evidence doesn't support its use for lowering cholesterol levels.
What is flaxseed oil used for?
Flaxseed oil is promoted for several conditions — obesity, arthritis, bipolar disorder, and high cholesterol — but the evidence shows it's possibly ineffective for these uses.
Can I take this if I'm breastfeeding?
Safety data during breastfeeding is limited. Use only with medical advice, so check with your doctor before taking this product while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flaxseed Oil Softgels is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flaxseed Oil Softgels label
Go deeper

The Full Monographs Behind Flaxseed Oil Softgels’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

Flaxseed Oil Softgels's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Flaxseed Oil 21 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed
  16. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
  18. Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
  19. Jamilian M, Tabassi Z, Reiner Z, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020;123(7):792-799
  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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