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Dietary supplement

Florajen Acidophilus Ingredients & Drug Interactions

by Florajen

Florajen Acidophilus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Florajen Acidophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Florajen Acidophilus is a dietary supplement by Florajen with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Florajen Acidophilus by Florajen

Ask about any prescription or over-the-counter medication and we check it for interactions with Florajen Acidophilus by Florajen — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Florajen Acidophilus by Florajen

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Lactobacillus acidophilus, a live beneficial bacterium (probiotic) that naturally lives in your digestive tract. The capsule also holds rice dextrin and gelatin as inactive ingredients — these are just the filler and capsule material that help deliver the probiotic to you.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: probiotic benefits and natural bacterial balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Rotaviral diarrhea.

The evidence shows L. acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For atopic disease (like eczema or allergies), the evidence suggests it's probably not effective.

There isn't enough reliable evidence yet to rate it for acute respiratory distress syndrome.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. In rare cases, people have reported mild gastrointestinal side effects — like stomach discomfort, bloating, gas, or diarrhea — when taking it with other probiotics; these are uncommon.

Very rarely, in people with certain health conditions, the live bacteria have been linked to serious infections like bacteremia or endocarditis, but this appears to happen mostly when bacteria move from other parts of the body. Because the safety data are limited, talk with your doctor or pharmacist before starting this product, especially if you have a weakened immune system or serious underlying illness.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any antibiotic drugs you're taking or may be prescribed — they can reduce how well this probiotic works if you take them at the same time. Space them out by a few hours, and ask your pharmacist for a timing plan.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Florajen Acidophilus is a single-ingredient probiotic that may help with IBS, antibiotic-associated diarrhea, and a few other digestive or bacterial issues. If you're on antibiotics, separate them from this supplement by a few hours to avoid reducing the probiotic's effectiveness.

Check your medications with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Florajen Acidophilus, straight from the product label.

Brand Florajen
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206104
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Florajen Acidophilus by Florajen, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Lactobacillus acidophilus0 NP--

Other ingredients: Rice Dextrin, Gelatin Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For potent probiotic benefits Probiotics are live bacteria and naturally die off at a faster rate when not refrigerated.

Promotes the body's natural balance of good bacteria

20 billion live cultures per capsule

Florajan Probiotics: Proven safe and effective strains Stomach acid resistant + bile tolerant

Satisfaction guaranteed: If you are not completely satisfied, we will refund your purchase. Go to florajan.com/refund for more information

Made in the U.S.A.

Brand IP Statement(s)

Florajen maintains a Cold Chain Commitment meaning that from the time our probiotics are manufactured to when they are placed in your hands Florajen is kept cold.

2017 American Lifeline, Inc. All rights reserved.

Formula

Lactobacillus Acidophilus is resilient and has demonstrated benefits in different parts of the body for overall balance and health. The human body contains trillions of microorganisms, so a probiotic with billions of cells is needed to help maintain balance. That is why Florajen Acidophilus offers 20 billion live cultures per capsule.

Dairy-free, gluten-free, allergen-free, non-GMO, Kosher, and manufactured in the USA in GMP-certified facilities.

Supports immune, digestive, vaginal & urinary health

Florajan Acidophilus: Promotes the natural balance of good bacteria

Storage

Refrigerated for freshness + potency

Storage: Refrigerate for maximum freshness and potency. Can be stored at room temperature for up to two weeks and still maintain effectiveness.

Suggested/Recommended/Usage/Directions

Once daily

Usage: Take 1 capsule daily with or without food unless a higher serving is recommended by your healthcare professional. For children under 6 months old, please check with your healthcare professional before use.

FDA Statement of Identity

Probiotic Supplement

Seals/Symbols

Allergen Free GF Gluten free Non GMO Made in USA GMP Certified Good Manufacturing Practice

Precautions

For children under 6 months old, please check with your healthcare professional before use.

Tamper evident. Do not use if safety seal on bottle is broken.

Formulation

Dairy-free, gluten-free, allergen-free, non-GMO, Kosher, and manufactured in the USA in GMP-certified facilities. Does not contain yeast, sugar, peanuts and tree nuts, soy, eggs, corn, wheat, fish, coloring, or preservatives.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Florajen Acidophilus by Florajen label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Florajen Acidophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Florajen Acidophilus by Florajen

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Lactobacillus acidophilus

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Rice Dextrin, Gelatin Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Florajen Acidophilus by Florajen Drug Interactions

Want to check YOUR meds against Florajen Acidophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Florajen Acidophilus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Florajen Acidophilus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Florajen Acidophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Florajen Acidophilus, from the product label.

Florajen

See all Florajen products
Name
American Lifeline, Inc.
Street Address
27070 Miles Road, Suite A
City
Solon
State
OH
ZipCode
44139
Phone Number
1-844-868-4567
Pharmacist Counseling Corner

Florajen Acidophilus by Florajen: Common Questions

Does Florajen Acidophilus by Florajen interact with any medications?
Yes. Based on its ingredients, Florajen Acidophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Florajen Acidophilus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work if I'm on antibiotics?
Not as well if you take them together. Antibiotics kill the live bacteria in this probiotic, so you'll get fewer active organisms. The solution is to separate them — take your antibiotic at one time of day and this supplement several hours apart. Your pharmacist can help you work out a schedule.
Is Lactobacillus acidophilus the same as the yogurt cultures?
It's the same type of bacteria, but this is a concentrated, live supplement rather than food. The product contains active organisms that you ingest orally, so the dose is much higher than what you'd get from yogurt.
Can I take this if I have a weak immune system?
The data are limited, and there is a rare concern that live bacteria could cause serious infection in people with weakened immunity. Talk with your doctor or pharmacist before using it if you have a compromised immune system or a serious underlying illness.
What side effects should I expect?
Most people tolerate it well. Rarely, some people report mild stomach discomfort, gas, bloating, or diarrhea, especially when combined with other probiotics — but these are uncommon. Rash has been reported in a clinical trial, though it's unclear whether the probiotic or another factor caused it.
Is it safe in pregnancy or while breastfeeding?
We don't have safety data on file for L. acidophilus in pregnancy or lactation. Talk with your doctor or pharmacist to decide whether it's right for you in either situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Florajen Acidophilus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Florajen Acidophilus label
Go deeper

The Full Monographs Behind Florajen Acidophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Florajen Acidophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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