Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Folic Acid 800 mcg Ingredients & Drug Interactions

by BIOVEA

Folic Acid 800 mcg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Folic Acid 800 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Folic Acid 800 mcg is a dietary supplement by BIOVEA with 1 active ingredient. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Folic Acid 800 mcg by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Folic Acid 800 mcg by BIOVEA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Folic Acid 800 mcg by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

BIOVEA's Folic Acid 800 mcg is a straightforward single-ingredient supplement. The active ingredient is folic acid, a B vitamin that your body uses to make and repair DNA and to create new cells.

The tablet also contains inactive ingredients—dicalcium phosphate, microcrystalline cellulose, vegetable magnesium stearate, and silica—which are fillers and binders that hold the tablet together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Folic Acid's overall clinical evidence instead.

Strong

Strong clinical evidence supports Folic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Folate deficiency — rated "Effective" (Natural Medicines).
  • On file: Methotrexate toxicity — rated "Likely Effective" (Natural Medicines).
  • On file: Neural tube birth defects — rated "Likely Effective" (Natural Medicines).
  • On file: Cognitive impairment — rated "Possibly Effective" (Natural Medicines).
  • On file: Depression — rated "Possibly Effective" (Natural Medicines).

The data shows folic acid is effective for treating folate deficiency—the condition it's designed for. It's also likely effective at reducing the toxicity of methotrexate and at preventing neural tube birth defects (like spina bifida) when taken at standard prenatal doses.

There's some evidence it may help with depression, phenytoin-induced gum overgrowth, and cognitive decline, though the proof isn't as solid for those uses.

The evidence, ingredient by ingredient Folic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid at the recommended dose is generally well tolerated in most adults. At very high doses—15 mg daily—some people experience confusion, sleep problems, irritability, and nausea.

Long-term use at high doses carries rare risks of cancer, cardiovascular issues, liver injury, and seizures. During pregnancy at standard prenatal doses, folic acid is recommended to prevent birth defects.

Population data suggests taking it late in pregnancy may slightly raise the risk of childhood asthma and respiratory infections, but taking it before or early in pregnancy does not show this association. Folic acid is considered safe at normal doses while breastfeeding.

One important caution: large doses of folic acid can worsen nerve damage in people who are deficient in vitamin B12, and taking it to treat an undiagnosed anemia can mask pernicious anemia and lead to nerve damage if the underlying B12 deficiency goes untreated.

Side effects, ingredient by ingredient Folic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take seizure medications (phenobarbital, phenytoin, or primidone), cancer treatments (methotrexate, capecitabine, or 5-fluorouracil), or pyrimethamine before starting this supplement. These are the main medication types affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This 800 mcg dose is straightforward—it works for folate deficiency and is commonly recommended during pregnancy. But if you take seizure medications, cancer drugs, or pyrimethamine, you'll need to talk with your doctor or pharmacist first.

Also, if you're anemic or suspect you are, don't self-treat; get the cause diagnosed so you're not masking something serious like B12 deficiency.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Folic Acid 800 mcg, straight from the product label.

Brand BIOVEA
Barcode (UPC) 818423029764
Net contents 30 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 211775
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Folic Acid 800 mcg by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Tablet(s)
Maximum serving Sizes:
1 Vegetarian Tablet(s)
Servings per container
30
UPC/BARCODE
818423029764
IngredientAmount% DV
Folic Acid800 mcg200%

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GMP Compliant VG Vegan

Suggested/Recommended/Usage/Directions

Suggested Daily Intake: Take 1 tablet daily with a meal.

General Statements

Guaranteed premium quality

Vitamin

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: If you are pregnant or lactating, consult a health care professional before using this product.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Folic Acid 800 mcg by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Folic Acid 800 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Folic Acid 800 mcg by BIOVEA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Folic Acid

Interacts with
40 drugs
800 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Folic Acid 800 mcg by BIOVEA Drug Interactions

Want to check YOUR meds against Folic Acid 800 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Moderate

Ingredients driving the most interactions

Folic Acid 40

Individual Drug Interactions

The ingredients in Folic Acid 800 mcg interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Folic Acid 800 mcg interact with drugs. Each result below shows which ingredient is responsible. Folic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Folic Acid 800 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Folic Acid 800 mcg, from the product label.

BIOVEA

See all BIOVEA products
Name
BIOVEA
Street Address
7702 East Doubletree Ranch Rd. Suite 300, #307
City
Scottsdale
State
AZ
ZipCode
85258
Phone Number
1-800-961-4750
Web Address
www.biovea.com
Pharmacist Counseling Corner

Folic Acid 800 mcg by BIOVEA: Common Questions

Does Folic Acid 800 mcg by BIOVEA interact with any medications?
Yes. Based on its ingredients, Folic Acid 800 mcg has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Folic Acid 800 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 800 mcg a safe daily dose?
Yes—folic acid is generally well tolerated at recommended doses like this one. Side effects are rare at this level. Very high doses (15 mg daily) can cause confusion, sleep trouble, and nausea, but you're well below that.
Can I take this during pregnancy?
Folic acid at standard prenatal doses is recommended during pregnancy to help prevent birth defects like spina bifida. Talk with your doctor about the right dose for you, since they may recommend more depending on your situation.
What if I have anemia—can I take this to treat it?
No—don't self-treat anemia with folic acid. Taking it without knowing what's causing the anemia can mask serious conditions like pernicious anemia (a B12 deficiency) and lead to nerve damage. Get your anemia diagnosed first by your doctor.
Can I take this if I'm deficient in vitamin B12?
Be cautious. High doses of folic acid can worsen nerve damage in people with B12 deficiency. If you suspect either deficiency, have your doctor check your B12 level before taking folic acid supplements.
Is this safe while breastfeeding?
Yes—folic acid is considered safe at normal recommended doses while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Folic Acid 800 mcg label
Go deeper

The Full Monographs Behind Folic Acid 800 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph →
Sources

Sources & How We Checked

Folic Acid 800 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
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  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
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  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
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  36. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
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  39. van Wijngaarden JP, Swart KM, Enneman AW, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin
  40. Qin X, Fan F, Cui Y, Chen F, Chen Y, Cheng X, Li Y, Wang B, Xu X, Xu X, Huo Y, Wang X. Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. Clin Nutr. 2014;33(4):603-12. PubMed
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  47. Van Der Woude DA, De Vries J, Van Wijk EM, Verzijl JM, Pijnenborg JM. A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartum anemia. Int J Gynaecol Obstet. 2014;126(2):101-5. PubMed
  48. Vila-Nova C, Wehby GL, Queirós FC, Chakraborty H, Félix TM, Goco N, Moore J, Gewehr EV, Lins L, Affonso CM, Murray JC. Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med. 201 PubMed
  49. Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, Armitage J, Manson JE, Hankey GJ, Spence JD, Galan P, Bønaa KH, Jamison R, Gaziano JM, Guarino P, Baron JA, Logan RF, Giovannucci EL, den Heijer M, Ueland PM, Bennett D, Collins R, Peto R; B-V
  50. Wehby GL, Félix TM, Goco N, Richieri-Costa A, Chakraborty H, Souza J, Pereira R, Padovani C, Moretti-Ferreira D, Murray JC. High dosage folic acid supplementation, oral cleft recurrence and fetal growth. Int J Environ Res Public Health. 2013 4;10(2):590-6 PubMed
  51. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
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  53. Houghton LA, Sherwood KL, Pawlosky R, Ito S, O'Connor DL. [6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation. Am J Clin Nutr. 2006 Apr;83(4):842-50. PubMed
  54. Houghton LA, Yang J, O'Connor DL. Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements. Am J Clin Nutr. 2009 Jan;89(1):216-20. PubMed
  55. Chan SL, Chan AWH, Mo F, et al. Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer. Oncologist. 2018 Dec;23(12):1436-1445. PubMed
  56. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T

See these in context on the Folic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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