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Dietary supplement

Forskolin 250 mg Ingredients & Drug Interactions

by Best Naturals

Forskolin 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Forskolin 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Forskolin 250 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for weight management, asthma and breathing, high blood pressure.Based on those ingredients, 915 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Coleus forskohlii Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Forskolin 250 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Forskolin 250 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Forskolin 250 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Forskolin 250 mg contains one active ingredient: coleus forskohlii root extract, which provides 250 mg per capsule. The formula includes cellulose, silica, and vegetable stearate as inactive ingredients for capsule structure and flow.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Coleus's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: weight management and fat breakdown.
  • We looked for evidence on: Obesity, body composition, metabolic rate, fat loss.
  • The closest evidence on file: Coleus is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence we hold on coleus is insufficient to establish whether it works for angina, asthma, cancer, congestive heart failure, atopic dermatitis (eczema), or dry eye. No effectiveness data in our files supports use for any of these conditions.

The evidence, ingredient by ingredient Coleus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coleus appears to be generally well tolerated when taken by mouth, though gastrointestinal effects—mainly dose-related diarrhea, loose stools, nausea, vomiting, and constipation—have been reported. One small trial noted loose stools in a small number of participants; retrospective reports suggest gastrointestinal problems occur in roughly 10% of oral users, with diarrhea accounting for the majority.

The safety data advises against use during pregnancy and while breastfeeding. Coleus may lower blood pressure and is not well studied for long-term use, so if you're considering it, talk with your doctor or pharmacist about whether it's right for you and how closely you should be monitored.

Side effects, ingredient by ingredient Coleus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 916 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on nitrates or calcium channel blockers—the combination could amplify heart effects dangerously. Also double-check if you take blood pressure medications, blood thinners, antiplatelet drugs, warfarin, or any drug that depends on CYP2C9 or CYP3A4 enzymes for how your body clears it.

Use the search tool to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Forskolin 250 mg is a single-ingredient supplement with no established effectiveness in our data for any condition listed. Because coleus carries serious theoretical interactions with heart medications and blood thinners, and potentially affects how many other drugs are cleared from your body, it's not a product to start without first checking your medications against the interaction tool on this page.

Pregnant or breastfeeding individuals should avoid it. Talk with your doctor or pharmacist before taking it, especially if you're on any heart, blood pressure, or anticoagulant medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Forskolin 250 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 859375002894
Net contents 60 Vcap(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269635
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Forskolin 250 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vcap(s)
Maximum serving Sizes:
1 Vcap(s)
Servings per container
30
UPC/BARCODE
859375002894
IngredientAmount% DV
Coleus forskohlii Root Extract250 mg--

Other ingredients: Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Forskolin is found in the roots of an herbal plant from the mint family. Researchers have found that forskolin can help to promote the breakdown of stored fats in animal and human fat cells. It may also release fatty acids from adipose tissue, which results in increased thermogenesis, resulting in loss of body fat and, theoretically, increased lean body mass. Supports fat metabolism, fat reduction and weight management. Supports heart and digestive health. Supports healthy vision.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule two times daily with full glass of water before meals on empty stomach, or as directed by your qualified healthcare professional.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Caution: For adults only, if you are pregnant, nursing, taking medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

Formulation

Weight management

Healthy fat metabolism

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Forskolin 250 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Forskolin 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Forskolin 250 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vcap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Coleus forskohlii Root Extract

Interacts with
915 drugs
250 mg per serving Form: Forskolin

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Coleus forskohlii Root Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Forskolin 250 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Forskolin 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
915Drugs
29 Major 886 Moderate

Ingredients driving the most interactions

Coleus forskohlii Root Extract 915

Individual Drug Interactions

The ingredients in Forskolin 250 mg interact with 915 drugs. Click any drug to see the details.

1 of the 1 ingredient in Forskolin 250 mg interact with drugs. Each result below shows which ingredient is responsible. Coleus forskohlii Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Forskolin 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coleus forskohlii Root Extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Forskolin 250 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Forskolin 250 mg by Best Naturals: Common Questions

Does Forskolin 250 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Forskolin 250 mg has a known interaction with 915 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Forskolin 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is coleus forskohlii, and what is it supposed to do?
Coleus forskohlii is a plant whose root extract contains forskolin, a compound that has been studied for conditions like angina, asthma, heart failure, and eczema. However, we don't have enough reliable evidence in our data to confirm it works for any of these uses.
Could this lower my blood pressure?
Yes, animal research suggests forskolin, the active component of coleus, may lower blood pressure. If you already take blood pressure medication or have low blood pressure, this is a reason to check with your doctor or pharmacist before starting it.
Is it safe during pregnancy or while breastfeeding?
No—the safety data advises against use in pregnancy and while breastfeeding. There isn't enough information to know it's safe, so avoid it if you're pregnant, planning to become pregnant, or nursing.
What side effects might I notice?
The most common oral side effects are gastrointestinal: diarrhea, loose stools, nausea, vomiting, or constipation. These tend to be dose-related. Overall, coleus is well tolerated, but if you develop persistent diarrhea or digestive upset, mention it to your pharmacist.
Why does this interact with so many medications?
Coleus works through two liver enzyme systems (CYP2C9 and CYP3A4) that clear hundreds of different drugs from your body. Depending on what drug you're taking, coleus may speed up or slow down how fast your body processes it, changing how well it works or raising the risk of side effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Forskolin 250 mg label
Go deeper

The Full Monographs Behind Forskolin 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph →
Sources

Sources & How We Checked

Forskolin 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coleus 16 references
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
  4. Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
  5. Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
  6. Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
  7. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
  8. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  9. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
  10. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
  11. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  12. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
  13. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
  14. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
  15. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
  16. Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed

See these in context on the Coleus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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