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Dietary supplement

GABA Natural Pina Colada Flavor Ingredients & Drug Interactions

by Natrol

GABA Natural Pina Colada Flavor label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GABA Natural Pina Colada Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GABA Natural Pina Colada Flavor is a dietary supplement by Natrol with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are GABA. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GABA Natural Pina Colada Flavor by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with GABA Natural Pina Colada Flavor by Natrol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GABA Natural Pina Colada Flavor by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Natrol GABA Natural Pina Colada contains one active ingredient: GABA (gamma-aminobutyric acid), a chemical your brain naturally uses to help you relax and sleep. The tablet also contains several inactive ingredients — xylitol, maltodextrin, stearic acid, silica, malic acid, modified food starch, cellulose gum, soy polysaccharides, citric acid, magnesium stearate, crospovidone, and natural flavors — that help form and flavor the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote relaxation, mental clarity and cope with stress.
  • We looked for evidence on: Anxiety, Stress, Psychological well-being, Insomnia, tension relief, nervousness.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being.

We don't have strong evidence that GABA supplements work for any of the uses they're marketed for. The facts on file rate it as having insufficient reliable evidence for anxiety, ADHD, athletic performance, chronic bronchitis, and cerebral palsy.

That doesn't mean it doesn't work — it means the research either isn't solid yet or isn't there. If you're thinking about using it for one of those reasons, talk with your doctor about what the current evidence shows and whether it might fit your situation.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, GABA is generally well tolerated short-term, though long-term safety hasn't been well studied. The most common side effects reported are drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea.

One person taking oral GABA together with another supplement (phosphatidylserine) reported a temporary stop in menstruation. The safety data is thin enough that it's best to avoid this product while breastfeeding unless your doctor advises otherwise.

There isn't enough safety information on file for pregnancy to say either way — talk with your doctor or pharmacist if you're pregnant or thinking about becoming pregnant.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before taking this if you take blood pressure medications — GABA may lower your blood pressure further. Also flag it if you take CNS depressants like sleeping pills, anti-anxiety medications, or alcohol, since adding GABA might increase drowsiness or sedation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GABA supplements aren't proven to work for anxiety, sleep, or the other things they're often sold for. If you take blood pressure medication or drugs that make you drowsy (like sleeping pills or anxiety medications), you'll want to check with your pharmacist or doctor before starting this, since GABA might add to those effects.

Long-term safety is unclear, so this isn't something to take indefinitely without guidance from your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA Natural Pina Colada Flavor, straight from the product label.

Brand Natrol
Barcode (UPC) 047469070700
Net contents 60 Chewable Tablet(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 78115
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA Natural Pina Colada Flavor by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
047469070700
IngredientAmount% DV
GABA41.7 mg--

Other ingredients: Xylitol, Maltodextrin, Stearic Acid, Silica, Malic Acid, modified Food Starch, Cellulose Gum, Soy Polysaccharides, Citric Acid, Magnesium Stearate, Crospovidone, natural Pina Colada flavor, Natural masking flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

GABA is a naturally occurring amino acid found in common foods like rice, tea, vegetables and fruits. Supplemental GABA has been shown to promote relaxation, mental clarity and the ability to cope with lifestyle stress.

New! Supports mental focus & clarity Promotes calm & relaxed mood

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs. Do not use if you are pregnant, lactating or under the age of 18 years.

Do not use if you are pregnant, lactating or under the age of 18 years.

People with allergies to wheat, soy or corn should consult their healthcare professional before taking this product.

Keep out of reach of children.

Contains wheat, soy

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

ITEM: 7070 F: 3003187 L: 2008147-15057

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one tablet up to two times daily. Tablets should be chewed before swallowing. No water necessary.

Formula

Contains wheat, soy

Formulation

No milk, egg, fish, crustacean shellfish, tree nuts, peanuts, yeast, artificial colors or flavors, or added preservatives

Brand IP Statement(s)

PharmaGABA is a registered trademark of Pharma Foods International Co., Ltd. (Japan)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GABA Natural Pina Colada Flavor by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GABA Natural Pina Colada Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GABA Natural Pina Colada Flavor by Natrol

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

GABA

Interacts with
419 drugs
41.7 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

Other (inactive) ingredients: Xylitol, Maltodextrin, Stearic Acid, Silica, Malic Acid, Modified Food Starch, Cellulose Gum, Soy Polysaccharides, Citric Acid, Magnesium Stearate, Crospovidone, Natural Pina Colada flavor, Natural masking flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

GABA Natural Pina Colada Flavor by Natrol Drug Interactions

Want to check YOUR meds against GABA Natural Pina Colada Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

GABA 419

Individual Drug Interactions

The ingredients in GABA Natural Pina Colada Flavor interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in GABA Natural Pina Colada Flavor interact with drugs. Each result below shows which ingredient is responsible. GABA

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA Natural Pina Colada Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GABA Natural Pina Colada Flavor, from the product label.

Natrol

See all Natrol products
Name
Natrol, LLC.
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

GABA Natural Pina Colada Flavor by Natrol: Common Questions

Does GABA Natural Pina Colada Flavor by Natrol interact with any medications?
Yes. Based on its ingredients, GABA Natural Pina Colada Flavor has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA Natural Pina Colada Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is GABA and what does it do?
GABA (gamma-aminobutyric acid) is a chemical your brain naturally makes to help you relax and sleep. This supplement contains GABA as an oral tablet. We don't have solid evidence yet that taking it by mouth produces the same effects as the GABA your body makes on its own.
Does this really help with anxiety or sleep?
The research isn't strong enough yet to say. According to the facts we have, anxiety, sleep problems, and other uses are rated as having insufficient reliable evidence. That means we don't have good studies backing it up — not that it definitely doesn't work, just that we don't know for sure.
What are the side effects?
The most common side effects people report with oral GABA are drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea. A thorough safety review hasn't been done, and long-term safety data is limited.
Is it safe while breastfeeding?
The safety data advises against it — there isn't enough information to know either way. Talk with your doctor or pharmacist before using this product if you're breastfeeding.
Can I take this if I'm on blood pressure medication?
That's a question for your pharmacist or doctor. GABA may lower blood pressure, and if you're already on a medication for that, combining them could drop your blood pressure too far. Check before you start.
Does it contain fillers or other ingredients?
Yes — the tablet contains several inactive ingredients like xylitol, maltodextrin, stearic acid, and natural flavors that help form and flavor it. The only active ingredient is GABA.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA Natural Pina Colada Flavor label
Go deeper

The Full Monographs Behind GABA Natural Pina Colada Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

GABA Natural Pina Colada Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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