Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Glucosamine & Chondroitin Soft Chews Ingredients & Drug Interactions

by Spring Valley

Glucosamine & Chondroitin Soft Chews label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glucosamine & Chondroitin Soft Chews against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Glucosamine & Chondroitin Soft Chews is a dietary supplement by Spring Valley with 3 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 170 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Glucosamine HCl, Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Glucosamine & Chondroitin Soft Chews by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Glucosamine & Chondroitin Soft Chews by Spring Valley — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Glucosamine & Chondroitin Soft Chews by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: glucosamine HCl and chondroitin sulfate, both compounds found naturally in joint cartilage. The soft chews also contain several inactive ingredients — sweeteners (corn syrup, high fructose corn syrup, sweetened condensed milk), fats (palm oil, monoglycerides, diglycerides), flavor enhancers (natural and artificial flavors, citric acid, soy lecithin), and a food coloring (FD&C Yellow #6).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: joint health.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Back pain, Temporomandibular disorders (TMD), cartilage support — and 1 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Temporomandibular disorders (TMD).

For osteoarthritis, glucosamine is rated Likely Effective — the evidence supports its use for joint pain and function. Chondroitin is rated Possibly Effective for osteoarthritis and cataracts.

For other conditions listed in the research — aging skin, back pain, colorectal issues, and liver disease — the evidence is insufficient to establish whether either ingredient truly works.

The evidence, ingredient by ingredient Chondroitin Sulfate Glucosamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both glucosamine and chondroitin are generally well tolerated by most adults, though quality and actual benefit vary between products. The most common side effects when taken by mouth are stomach issues: bloating, constipation, diarrhea, heartburn, nausea, and abdominal pain or cramps.

Rare serious side effects include liver damage (hepatotoxicity). Some people report skin reactions — rash, hives, swelling around the eyes, or hair loss — particularly with glucosamine-chondroitin combinations.

Very rare cases of asthma flare-ups and one reproducible case of sun sensitivity have been reported. Glucosamine also carries a small allergic-reaction risk; one review found that about 1.5% of reported adverse events were anaphylaxis.

During pregnancy, there is not enough safety information; the data advises against use. While breastfeeding, safety is unknown; avoid unless your doctor says otherwise.

Side effects, ingredient by ingredient Chondroitin Sulfate Glucosamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chondroitin Sulfate, Glucosamine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 170 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or other blood thinners, this product is a major concern — it could increase your bleeding risk. Also double-check if you're on topoisomerase II inhibitor chemotherapy drugs (like etoposide or doxorubicin), diabetes medications, or acetaminophen regularly before starting.

Discuss these with your doctor or pharmacist before taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is an option if you have osteoarthritis and want to try glucosamine and chondroitin together — the evidence supports glucosamine especially. Anyone taking warfarin (a blood thinner) needs to check with their doctor or pharmacist first, as this product could increase bleeding risk.

Same goes if you're on chemotherapy, diabetes medication, or regular acetaminophen. Talk it over with your own doctor or pharmacist to see if it's right for you and to confirm it won't clash with your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glucosamine & Chondroitin Soft Chews, straight from the product label.

Brand Spring Valley
Net contents 50 Soft Chew(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 26372
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glucosamine & Chondroitin Soft Chews by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Chew(s)
Maximum serving Sizes:
3 Chew(s)
Servings per container
16
IngredientAmount% DV
Calories60 {Calories}--
Total Carbohydrates12 Gram(s)4%
Sugar6 Gram(s)--
Calories from Fat15 {Calories}--
Saturated Fat1.5 Gram(s)8%
Total Fat1.5 Gram(s)2%
Chondroitin Sulfate1.2 Gram(s)--
Glucosamine HCl1.5 Gram(s)--

Other ingredients: Corn Syrup, Sweetened Condensed Whole Milk, Palm Oil, Whey, High Fructose Corn Syrup, Monoglycerides, Diglycerides, Citric Acid, Natural & Artificial flavors, Soy Lecithin, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

VITAMIN #1 BRAND

QUALITY ASSURANCE GUARANTEE

Formula

3 Chews Deliver 1,500 mg Glucosamine HCl 1,200 mg Chondroitin Sulfate

General Statements

Not actual size

JOINT HEALTH

Delicious Orange Cream Flavor Naturally and Artificially Flavored

- Produced under strict quality guidelines. - Verified by an independent ISO 9001:2000 certified laboratory. UNCONDITIONALLY GUARANTEED BY REFUND OR REPLACEMENT

Glucosamine Chondroitin Soft Chews are an easy and delicious way to provide proper nutrition to joint tissues and help promote flexibility, range of motion and joint lubrication. All About Health Joints Your joints are natural mechanical marvels, but like all things with moving parts, wear and tear can take a toll. Years of repetitive motion can affect the slick, protective cartilage that acts as a "shock absorber" covering the ends of bones. When this happens, mobility and comfort may be compromised. What is Cartilage? Cartilage is made of a mesh of collagen and a gel of proteoglycans. The cells that help break down and dispose of old cartilage and replace it with new materials are called chondrocytes. What Roles do Glucosamine and Chondroitin Play? Both Glucosamine and Chondroitin are components of cartilage, in healthy younger individuals, these materials are readily available for rebuilding cartilage. But as we age, demand may exceed supply. What's more, there are no practical food sources of either Glucosamine or Chondroitin, other than supplements.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: For adults, take three (3) delicious soft chews daily, or as recommended by a physician. Three chews may be enjoyed all at once or taken throughout the day.

Precautions

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF THE REACH OF CHILDREN.

Formulation

No Gluten, No Yeast, No Wheat, No Preservatives, No Sodium (less than 5 mg per serving).

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

Prod. No. 51095 B51095W Rev. 02B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glucosamine & Chondroitin Soft Chews by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glucosamine & Chondroitin Soft Chews label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glucosamine & Chondroitin Soft Chews by Spring Valley

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Chew(s) Dosage formOther (e.g. Tea Bag) Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

6 Gram(s) per serving

Chondroitin Sulfate

Interacts with
2 drugs
1.2 Gram(s) per serving

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

Chondroitin Sulfate monograph & interactions

Glucosamine HCl

Interacts with
170 drugs
1.5 Gram(s) per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine HCl monograph & interactions

Other (inactive) ingredients: Corn Syrup, Sweetened Condensed Whole Milk, Palm Oil, Whey, High Fructose Corn Syrup, Monoglycerides, Diglycerides, Citric Acid, Natural & Artificial flavors, Soy Lecithin, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glucosamine & Chondroitin Soft Chews by Spring Valley Drug Interactions

Want to check YOUR meds against Glucosamine & Chondroitin Soft Chews?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
170Drugs
2 Major 13 Moderate 155 Minor

Ingredients driving the most interactions

Glucosamine HCl 170
Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Glucosamine & Chondroitin Soft Chews interact with 170 drugs. Click any drug to see the details.

2 of the 3 ingredients in Glucosamine & Chondroitin Soft Chews interact with drugs. Each result below shows which ingredient is responsible. Glucosamine HCl Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Glucosamine & Chondroitin Soft Chews with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucosamine HCl4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine HCl full monograph & interactions

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glucosamine & Chondroitin Soft Chews, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
Pharmacist Counseling Corner

Glucosamine & Chondroitin Soft Chews by Spring Valley: Common Questions

Does Glucosamine & Chondroitin Soft Chews by Spring Valley interact with any medications?
Yes. Based on its ingredients, Glucosamine & Chondroitin Soft Chews has a known interaction with 170 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glucosamine & Chondroitin Soft Chews contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data for either ingredient during pregnancy; the data advises against it. While breastfeeding, safety is unknown, so avoid it unless your doctor says it's okay. Talk with your doctor or pharmacist about what's safe for you.
What are the most common side effects?
Stomach upset is most common: bloating, constipation, diarrhea, heartburn, nausea, and abdominal pain. Some people also report skin reactions like rash or hives. Serious side effects are rare but can include liver damage and, very rarely, asthma flare-ups or allergic reactions.
Will this actually help my osteoarthritis?
Glucosamine is rated Likely Effective for osteoarthritis, so the evidence supports it. Chondroitin is rated Possibly Effective. That said, benefit varies between people and between products, so quality matters.
Is this product safe if I have diabetes and take medication?
There's a Minor interaction — early research raised concerns that glucosamine might worsen diabetes control, but newer evidence suggests it's unlikely to actually interfere with your medication. Still, check with your doctor or pharmacist before starting, especially if your blood sugar is hard to manage.
What exactly is chondroitin?
Chondroitin is a natural compound found in cartilage — the rubbery tissue that cushions joints. It's thought to help maintain cartilage structure and reduce inflammation, though the evidence is mixed.
Can I take this with acetaminophen (Tylenol)?
There's a Minor interaction: acetaminophen may reduce the pain-relief effects of glucosamine when you take them together. If you use acetaminophen regularly, check with your doctor or pharmacist before adding this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glucosamine & Chondroitin Soft Chews is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glucosamine & Chondroitin Soft Chews label
Go deeper

The Full Monographs Behind Glucosamine & Chondroitin Soft Chews’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph →
Sources

Sources & How We Checked

Glucosamine & Chondroitin Soft Chews's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
  6. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
  7. Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
  8. Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
  9. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
  10. Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  12. Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
  13. Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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