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Dietary supplement

Golden Thread Supreme 545 mg Ingredients & Drug Interactions

by Supreme Nutrition Products

Golden Thread Supreme 545 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Golden Thread Supreme 545 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Golden Thread Supreme 545 mg is a dietary supplement by Supreme Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for digestive upset and diarrhea, mouth sores and sore throat, inflammation.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Golden Thread. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Golden Thread Supreme 545 mg by Supreme Nutrition Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Golden Thread Supreme 545 mg by Supreme Nutrition Products — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Golden Thread Supreme 545 mg by Supreme Nutrition Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Golden Thread Supreme contains one active ingredient: goldthread, at 545 mg per capsule. Goldthread is a plant traditionally used in herbal medicine; its primary active compound is berberine.

The capsule itself is made from vegetable cellulose.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Goldthread product and its label doesn't state a use — see Goldthread's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness data on file for goldthread for any particular use.

The evidence, ingredient by ingredient Goldthread

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Goldthread may be tolerated short-term by some adults, but human safety data are limited and the quality of goldthread products can vary considerably between manufacturers. The safety data advises against using goldthread during pregnancy—berberine, its main active compound, may harm the fetus.

Similarly, berberine passes into breast milk and may harm infants, so goldthread should be avoided while breastfeeding.

Side effects, ingredient by ingredient Goldthread

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Goldthread.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take cyclosporine or any medication metabolized by the CYP3A4 enzyme—a large group that includes certain cholesterol, heart, and immunosuppressant drugs, among many others.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you take cyclosporine or any other regular medication metabolized by your liver, talk with your doctor or pharmacist before starting goldthread. The ingredient's safety profile in humans is not well established, and pregnancy and breastfeeding are contraindications based on the berberine content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Golden Thread Supreme 545 mg, straight from the product label.

Brand Supreme Nutrition Products
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 252062
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Golden Thread Supreme 545 mg by Supreme Nutrition Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Golden Thread545 mg--

Other ingredients: Vegetable Cellulose Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule 3 times per day.

Precautions

Warning: Golden Thread should not be used during pregnancy or if breastfeeding.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent or cure any disease or illness.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Golden Thread Supreme 545 mg by Supreme Nutrition Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Golden Thread Supreme 545 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Golden Thread Supreme 545 mg by Supreme Nutrition Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Golden Thread

Interacts with
643 drugs
545 mg per serving

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and an...

Golden Thread monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Golden Thread Supreme 545 mg by Supreme Nutrition Products Drug Interactions

Want to check YOUR meds against Golden Thread Supreme 545 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Moderate

Ingredients driving the most interactions

Golden Thread 643

Individual Drug Interactions

The ingredients in Golden Thread Supreme 545 mg interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Golden Thread Supreme 545 mg interact with drugs. Each result below shows which ingredient is responsible. Golden Thread

Each ingredient & the kinds of drugs it affects

For each ingredient in Golden Thread Supreme 545 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Golden Thread2 drug types · 643 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme. So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D
Golden Thread full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Golden Thread Supreme 545 mg, from the product label.

Supreme Nutrition Products

See all Supreme Nutrition Products products
Name
Supreme Nutrition Products
Street Address
1019 Regents Blvd #203
City
Tacoma
State
WA
ZipCode
98466
Web Address
www.SupremeNutritionProducts.com
Pharmacist Counseling Corner

Golden Thread Supreme 545 mg by Supreme Nutrition Products: Common Questions

Does Golden Thread Supreme 545 mg by Supreme Nutrition Products interact with any medications?
Yes. Based on its ingredients, Golden Thread Supreme 545 mg has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Golden Thread Supreme 545 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against goldthread during pregnancy because berberine may harm the fetus, and during breastfeeding because it passes into breast milk and may harm infants. Talk with your doctor about alternatives if you're pregnant, planning to become pregnant, or nursing.
Is this product standardized or consistent between brands?
The data notes that quality varies between products. If you choose to use goldthread, look for a reputable manufacturer and check the label for berberine content or standardization information.
How long is it safe to take goldthread?
Human safety data are limited. The data suggests some adults may tolerate it short-term, but long-term safety is not well established. Talk with your doctor or pharmacist about how long is appropriate for your situation.
Will goldthread affect my liver or kidney function?
The data we have focuses on how goldthread affects how your liver breaks down certain drugs, but we don't have broader safety information on liver or kidney effects. Discuss any concerns about organ function with your doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Golden Thread Supreme 545 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Golden Thread Supreme 545 mg label
Go deeper

The Full Monographs Behind Golden Thread Supreme 545 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Goldthread

Interacts with 643 drugs

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and antimicrobial effects. Strong human eviden...

Read the full Goldthread monograph →
Sources

Sources & How We Checked

Golden Thread Supreme 545 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Goldthread 3 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

See these in context on the Goldthread monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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