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Dietary supplement

Gotu Kola 250 mg Ingredients & Drug Interactions

by Vitamin World

Gotu Kola 250 mg label
See full label image
Unknown Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gotu Kola 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gotu Kola 250 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gotu Kola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gotu Kola 250 mg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Gotu Kola 250 mg by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gotu Kola 250 mg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gotu kola, a plant traditionally used in Asian medicine. Each capsule provides 250 mg of the herb.

The remaining ingredients — dicalcium phosphate, vegetable cellulose, calcium silicate, silica, and vegetable magnesium stearate — are inactive excipients (fillers and binders) that make up the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: food for the brain and wellness.
  • We looked for evidence on: Cognitive function, Wound healing, Venous insufficiency, Scarring, Hypertrophic scars, Keloids — and 4 related terms.
  • The strongest evidence on file: Gotu Kola is rated "Possibly Effective" for Venous insufficiency (Natural Medicines).
  • Also on file: Gotu Kola is rated "Possibly Ineffective" for Cognitive function.
  • Also on file: Gotu Kola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Keloids, Scarring, Wound healing, and more.

Gotu kola is possibly effective for venous insufficiency (poor circulation in the legs) and burns based on the evidence we hold. For radiation dermatitis (skin damage from radiation therapy), cognitive function, and Alzheimer's disease, the evidence either doesn't support it (radiation dermatitis) or isn't strong enough to rate (cognitive function and Alzheimer's disease).

Data on generalized anxiety disorder is also insufficient to say whether it works.

The evidence, ingredient by ingredient Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gotu kola is generally well tolerated when taken short-term by mouth or applied to skin, though quality evidence is limited and liver concerns have been reported. The most common side effects are stomach irritation and nausea when taken orally; when applied topically, eczema and allergic contact dermatitis can occur.

Rarely, liver toxicity has been reported — though four documented cases exist, contaminants in those products couldn't be ruled out. In one clinical trial where liver function was monitored, 120 mg daily for 6 months caused no liver problems.

There isn't enough safety data to recommend gotu kola during pregnancy, so it's traditionally avoided. Safety during breastfeeding is unknown, so it's best avoided.

Talk with your doctor or pharmacist about whether this product is right for your individual situation.

Side effects, ingredient by ingredient Gotu Kola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you're on CNS depressants (sedatives, sleep aids, anti-anxiety medications, or other drugs that make you drowsy) — gotu kola may boost their sedative effects. Also flag it if you take any hepatotoxic drugs (medications known to stress the liver), since adding gotu kola might increase that risk.

Use the medication checker on this page for your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Consider gotu kola if you're exploring options for venous insufficiency or wound healing and want to explore what the evidence supports. Be cautious if you take sedating medications or drugs that stress your liver — these are your main interaction concerns.

Discuss this product with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or taking prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gotu Kola 250 mg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 074312722004
Net contents 100 Microlozenge(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 610
Product type Botanical
Supplement form Unknown
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gotu Kola 250 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
4 Caplet(s)
UPC/BARCODE
074312722004
IngredientAmount% DV
Gotu Kola250 mg--

Other ingredients: Dicalcium Phosphate, Vegetable Cellulose, Calcium Silicate, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

(C)2009 Vitamin World, Inc.

FDA Statement of Identity

NATURAL WHOLE HERB Vegetarian Herbal Supplement

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Precautions

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18. Keep out of reach of children. Store in a cool, dry place. Do not use if seal under cap is broken or missing.

General Statements

250 MG

Gotu Kola contains Saponins - highly complex phytochemicals that play a role in wellness. Often referred to as, “food for the brain,” Gotu Kola is a popular herb used in Ayurveda practices.

QUALITY ASSURED Vitamin World products are subject to critically stringent quality assurance analysis. Our state-of-the-art laboratory, manufacturing and packaging facilities insure the highest quality nutritional supplements money can buy. Your health & safety are our first priority!

Traditional Goodness from Mother Nature

Vitamin World’s Natural Whole Herb products utilize ground plant parts to provide the natural components in the amounts found in nature.

Get healthy.

General

PROD. #220 B2200 00A

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) to four (4) caplets daily, preferably with meals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gotu Kola 250 mg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gotu Kola 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gotu Kola 250 mg by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formUnknown Amounts shown are per serving.

Gotu Kola

Interacts with
579 drugs
250 mg per serving

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Vegetable Cellulose, Calcium Silicate, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gotu Kola 250 mg by Vitamin World Drug Interactions

Want to check YOUR meds against Gotu Kola 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Gotu Kola 579

Individual Drug Interactions

The ingredients in Gotu Kola 250 mg interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gotu Kola 250 mg interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola

Each ingredient & the kinds of drugs it affects

For each ingredient in Gotu Kola 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gotu Kola 250 mg, from the product label.

Vitamin World

See all Vitamin World products
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Gotu Kola 250 mg by Vitamin World: Common Questions

Does Gotu Kola 250 mg by Vitamin World interact with any medications?
Yes. Based on its ingredients, Gotu Kola 250 mg has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gotu Kola 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gotu kola while I'm pregnant?
There isn't enough safety data to know either way. The product is traditionally avoided during pregnancy. Talk with your doctor or pharmacist about whether it's appropriate for your situation.
Can I take gotu kola if I'm breastfeeding?
Safety during breastfeeding is unknown, so it's best avoided. Discuss this with your doctor or pharmacist before taking it.
What are the most common side effects?
When taken by mouth, the most common side effects are stomach irritation and nausea. Applied to skin, it can cause eczema or allergic contact dermatitis in some people.
Does gotu kola really work for anxiety?
The evidence isn't strong enough to say. We don't have reliable data on whether it helps generalized anxiety disorder, so I can't confirm it works for that.
What is gotu kola used for?
In this product, gotu kola is included because it's possibly effective for venous insufficiency (poor leg circulation) and burns. It's been used traditionally in Asian medicine, though evidence is limited for many claimed uses.
Can gotu kola harm my liver?
There are four case reports of liver toxicity linked to gotu kola, but it's unclear whether gotu kola was the cause or whether contaminants in those products were responsible — they were never tested. In one monitored clinical trial, 120 mg daily for 6 months caused no liver problems.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gotu Kola 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gotu Kola 250 mg label
Go deeper

The Full Monographs Behind Gotu Kola 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Gotu Kola 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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