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Dietary supplement

Gotu Kola 330 mg Ingredients & Drug Interactions

by Nature's Answer

Gotu Kola 330 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gotu Kola 330 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gotu Kola 330 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gotu Kola (Centella asiatica) (leaf) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gotu Kola 330 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Gotu Kola 330 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gotu Kola 330 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gotu kola (Centella asiatica) leaf extract at 330 mg per capsule. Gotu kola is a plant used in traditional medicine, particularly in Asian healing practices.

The capsule itself is made from inactive ingredients—rice flour, vegetable cellulose, and calcium silicate—which are fillers and binders that help hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy immune support natural botanical energizer.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for gotu kola is mixed and depends on what you're using it for. It's rated possibly effective for venous insufficiency (poor circulation in the veins) and for burns.

For radiation dermatitis (skin damage from radiation therapy), the evidence suggests it's possibly ineffective. For cognitive function and Alzheimer's disease, there isn't enough reliable evidence to say whether it works.

The same goes for generalized anxiety—the data we hold shows insufficient evidence to rate it.

The evidence, ingredient by ingredient Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gotu kola is generally well tolerated in the short term, though quality evidence is limited and some liver concerns have been reported. The most common side effects when taken by mouth are gastric irritation and nausea.

Serious liver damage is rare but has been documented in at least four case reports; however, it's unclear whether gotu kola itself or contaminants in those products were responsible. One clinical trial found that 120 mg daily for 6 months did not affect liver function.

During pregnancy, there isn't enough safety data, so it's traditionally been avoided. During breastfeeding, safety is unknown, so it's best avoided as well.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Gotu Kola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take gotu kola, double-check it with your doctor or pharmacist if you're on CNS depressants (sedatives, sleep aids, anti-anxiety medications) or hepatotoxic drugs (medications that stress the liver). Both carry Moderate-severity interaction concerns.

Use the medication checker on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gotu Kola 330 mg might be worth considering if you're interested in supporting circulation or healing minor burns, though the evidence is modest. You should be careful if you take sedating medications (like sleep aids or anxiety medications) or drugs that can affect your liver—gotu kola can intensify both effects.

If you're pregnant, breastfeeding, or taking any medications, check with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gotu Kola 330 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000163937
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 184891
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gotu Kola 330 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
083000163937
IngredientAmount% DV
Gotu Kola (Centella asiatica) (leaf) extract330 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Discover Nature's Answer and trust the Difference... The True Nature of Our Standards go way beyond the herb...

Discover Nature's Answer

2017 Nature's Answer

FDA Disclaimer Statement

Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Seals/Symbols

Gluten Free

General Statements

Since 1972 Healthy Immune Support Natural Botanical Energizer

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten-Free

Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule twice a day with food or water.

Precautions

Warning: Keep Out of Reach of Children.

Do not use if safety seal is damaged or missing.

Do not use if you are pregnant, or nursing. If you are taking any medication, planning any medical procedure or have a medical condition, consult with your healthcare practitioner before use.

General

18393 Rev. 617

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gotu Kola 330 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gotu Kola 330 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gotu Kola 330 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Gotu Kola (Centella asiatica) (leaf) extract

Interacts with
579 drugs
330 mg per serving Form: Triterpenes

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola (Centella asiatica) (leaf) extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gotu Kola 330 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Gotu Kola 330 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Gotu Kola (Centella asiatica) (leaf) extract 579

Individual Drug Interactions

The ingredients in Gotu Kola 330 mg interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gotu Kola 330 mg interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola (Centella asiatica) (leaf) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gotu Kola 330 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola (Centella asiatica) (leaf) extract2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola (Centella asiatica) (leaf) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gotu Kola 330 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Gotu Kola 330 mg by Nature's Answer: Common Questions

Does Gotu Kola 330 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Gotu Kola 330 mg has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gotu Kola 330 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gotu kola if I'm pregnant?
There isn't enough safety data on gotu kola during pregnancy, and it's traditionally been avoided. Talk with your doctor or pharmacist about whether it's right for you—they can weigh the risks and benefits for your individual situation.
Can I take gotu kola while breastfeeding?
Safety during breastfeeding is unknown, so it's best avoided. If you're interested in taking it, check with your doctor or pharmacist first.
What are the most common side effects?
Stomach irritation and nausea are the most common side effects when you take it by mouth. These are usually mild, though the evidence on long-term use is limited.
Will gotu kola help with brain fog or memory?
The evidence on cognitive function and Alzheimer's disease isn't established in the data we hold—there's insufficient reliable evidence to say whether it works for memory or brain fog.
Is gotu kola safe for long-term use?
Gotu kola is generally well tolerated in the short term, but quality evidence on long-term safety is limited. Liver concerns have been reported in rare cases, though it's unclear whether the supplement itself or contaminants were responsible. If you're considering long-term use, talk with your doctor or pharmacist about monitoring.
Does gotu kola work for anxiety?
There isn't enough reliable evidence to say whether gotu kola helps with generalized anxiety. If you're considering it for anxiety, talk with your doctor or pharmacist about what the evidence supports.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gotu Kola 330 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gotu Kola 330 mg label
Go deeper

The Full Monographs Behind Gotu Kola 330 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Gotu Kola 330 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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