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Dietary supplement

Gotu Kola Aerial Extract 250 mg Ingredients & Drug Interactions

by Solaray

Gotu Kola Aerial Extract 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gotu Kola Aerial Extract 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gotu Kola Aerial Extract 250 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gotu Kola aerial extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gotu Kola Aerial Extract 250 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Gotu Kola Aerial Extract 250 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gotu Kola Aerial Extract 250 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gotu kola aerial extract at 250 mg per capsule. Gotu kola is a plant traditionally used to support circulation and skin health.

The capsule itself and other ingredients listed—vegetable cellulose, cellulose, and maltodextrin—are inactive (they're the capsule shell and fillers that hold the extract together).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Gotu Kola's overall clinical evidence instead.

Moderate

Some clinical evidence supports Gotu Kola for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Burns — rated "Possibly Effective" (Natural Medicines).
  • On file: Venous insufficiency — rated "Possibly Effective" (Natural Medicines).

Gotu kola is possibly effective for venous insufficiency (poor circulation in the legs and feet) and for wound healing in burns. The evidence is mixed for other uses: it's rated possibly ineffective for radiation-related skin damage, possibly ineffective for memory and thinking, and there isn't reliable evidence yet to say whether it helps Alzheimer's disease or generalized anxiety.

If circulation or wound healing is why you're considering it, the data offer some support—but talk with your doctor about whether it's right for your situation.

The evidence, ingredient by ingredient Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gotu kola is generally well tolerated when taken by mouth over the short term, though high-quality safety studies are limited. The most common side effects are stomach upset and nausea.

Rarely, liver toxicity has been reported, though it's not confirmed whether gotu kola itself was responsible or whether the products involved were contaminated; one study monitoring liver function found no changes with 120 mg daily for 6 months. Topically, it can cause eczema or allergic skin reactions in some people.

The safety data advises against use during pregnancy, and there isn't enough information to know whether it's safe during breastfeeding—talk with your doctor or pharmacist before taking it if you're pregnant or nursing.

Side effects, ingredient by ingredient Gotu Kola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on CNS depressants (sedating drugs like sleep aids, anti-anxiety medications, or opioid pain relievers)—gotu kola may strengthen their drowsy effects. Also double-check if you take any medication known to affect your liver function.

Altogether, these interactions span 580 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Gotu Kola Aerial Extract may help with leg circulation and wound healing, but it can interact with sedating medications and drugs that affect your liver. If you take anything for sleep, anxiety, pain, or liver function, check with your doctor or pharmacist first.

It's best avoided in pregnancy and breastfeeding without professional guidance. A quick medication check on this page can tell you if your drugs are affected.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gotu Kola Aerial Extract 250 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280033007
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255662
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gotu Kola Aerial Extract 250 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
60
UPC/BARCODE
076280033007
IngredientAmount% DV
Gotu Kola aerial extract250 mg--

Other ingredients: Vegetable Cellulose Capsule, Cellulose, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Centella asiatica 10% Triterpenes

Discussion: Gotu kola is a perennial plant native to India and China with a long history of use in both Ayruvedic and Traditional Chinese Medicine.

Gotu kola contains a number of key phytonutrients including the saponin compounds known as triterpenoids.

Formulation

Guaranteed potency Lab verified

Studies suggest that gotu kola may support blood vessel integrity and help promote healthy circulation.

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take one VegCap twice daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gotu Kola Aerial Extract 250 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gotu Kola Aerial Extract 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gotu Kola Aerial Extract 250 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Gotu Kola aerial extract

Interacts with
579 drugs
250 mg per serving Form: Triterpenes

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola aerial extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Cellulose, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gotu Kola Aerial Extract 250 mg by Solaray Drug Interactions

Want to check YOUR meds against Gotu Kola Aerial Extract 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Gotu Kola aerial extract 579

Individual Drug Interactions

The ingredients in Gotu Kola Aerial Extract 250 mg interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gotu Kola Aerial Extract 250 mg interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola aerial extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gotu Kola Aerial Extract 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola aerial extract2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola aerial extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gotu Kola Aerial Extract 250 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Gotu Kola Aerial Extract 250 mg by Solaray: Common Questions

Does Gotu Kola Aerial Extract 250 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Gotu Kola Aerial Extract 250 mg has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gotu Kola Aerial Extract 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will gotu kola make me drowsy if I take it with a sleep aid?
Possibly. Gotu kola seems to have mild sedative activity, and taking it with sedating drugs like benzodiazepines or prescription sleep aids could add to their drowsy effects. If you're on any sleep or anxiety medication, check with your doctor or pharmacist before adding this.
Is gotu kola safe for my liver?
It's generally well tolerated, but there's a caution flag. A few case reports mention liver toxicity, though it's not proven gotu kola caused it—contamination wasn't tested for, and doses weren't recorded. One trial using 120 mg daily for 6 months saw no liver function changes. If you have liver disease or take drugs that stress your liver, talk to your pharmacist first.
What's gotu kola actually used for?
It's possibly effective for venous insufficiency (poor leg circulation) and burn wound healing. For memory, Alzheimer's, and anxiety, the evidence isn't strong enough yet to say whether it works. A doctor can help you figure out if it's appropriate for what you need.
Can I take this if I'm pregnant?
The safety data advises against it—there isn't enough evidence to know it's safe in pregnancy. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant.
What are the most common side effects?
When taken by mouth, stomach upset and nausea are the most common. If you apply it to skin, it can cause eczema or allergic reactions in some people. Most people tolerate it without problems, especially over the short term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gotu Kola Aerial Extract 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gotu Kola Aerial Extract 250 mg label
Go deeper

The Full Monographs Behind Gotu Kola Aerial Extract 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Gotu Kola Aerial Extract 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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