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Dietary supplement

GPC (GlyceroPhosphoCholine) Ingredients & Drug Interactions

by AB American Biologics

GPC (GlyceroPhosphoCholine) label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GPC (GlyceroPhosphoCholine) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

GPC (GlyceroPhosphoCholine) is a dietary supplement by AB American Biologics with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are sn-Glycero (3) Phosphocholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GPC (GlyceroPhosphoCholine) by AB American Biologics

Ask about any prescription or over-the-counter medication and we check it for interactions with GPC (GlyceroPhosphoCholine) by AB American Biologics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GPC (GlyceroPhosphoCholine) by AB American Biologics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sn-Glycero(3) Phosphocholine, commonly called alpha-GPC. It's a naturally occurring compound believed to support brain function and cognitive health.

The capsules also contain two inactive ingredients — magnesium stearate and microcrystalline cellulose — which are common binders and fillers used in supplement capsules.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain and body nutrient.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, Age-related cognitive decline, Memory, Learning.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed. It's rated possibly effective for Alzheimer disease, meaning some clinical support exists.

For brain tumors, cognitive function, vascular dementia, and stroke, the evidence is insufficient — meaning we don't yet have reliable data to say whether it works for those purposes. If you're considering it for a specific condition, talk with your doctor about what the current research actually shows for your situation.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, though long-term safety hasn't been fully established. A small number of trial participants experienced dizziness, headache, insomnia, and excitation; some reported nausea, heartburn, or diarrhea.

Rarely, stroke has been reported in people taking alpha-GPC orally for at least two months — a serious finding that deserves discussion with your doctor if you're thinking of long-term use. The facts available don't include enough safety information during pregnancy or lactation to say whether it's appropriate; talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you use the scopolamine patch (Transderm Scop) for motion sickness, check with your doctor or pharmacist before taking this product — alpha-GPC may theoretically weaken the patch's anti-nausea effects. For any other prescription medications, use the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if you're exploring support for Alzheimer disease, though the evidence is modest. The scopolamine patch interaction is minor but real if you use it for motion sickness.

The rare risk of stroke with long-term use is something to weigh carefully with your doctor. Talk it over with your healthcare provider before starting, especially if you take any medications or have concerns about long-term safety.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GPC (GlyceroPhosphoCholine), straight from the product label.

Brand AB American Biologics
Barcode (UPC) 690290530068
Net contents 60 Vegetarian Capsule(s); 1.5 oz.; 42 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 203332
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GPC (GlyceroPhosphoCholine) by AB American Biologics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
690290530068
IngredientAmount% DV
sn-Glycero (3) Phosphocholine300 mg--

Other ingredients: Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains: Soy

GPC or ClyceroPhosphoCholine is an orthomolecular nutrient. Research suggests that GPC nutritionally supports cell homeostasis, tissue growth and renewal, organ vitality, and mind-body integration.

Precautions

Contains: Soy

Pregnant or nursing mothers should consult a physician before using dietary supplements.

Keep out of the reach of children.

Formulation

Free of: Gluten, yeast, wheat, corn, dairy, sugar, starch, artificial coloring or flavoring

General

Label Rev. 10/14

FDA Statement of Identity

Dietary Supplement

General Statements

Brain and Body Nutrient

Formulated by Parris M. Kidd, PhD

Suggested/Recommended/Usage/Directions

Recommended use: As an adult dietary supplement, take 1-2 capsules between meals daily or as directed by a healthcare practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GPC (GlyceroPhosphoCholine) by AB American Biologics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GPC (GlyceroPhosphoCholine) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GPC (GlyceroPhosphoCholine) by AB American Biologics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Sn-Glycero (3) Phosphocholine

Interacts with
16 drugs
300 mg per serving Form: Choline Alphoscerate, GlyceroPhosphoCholine

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Sn-Glycero (3) Phosphocholine monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

GPC (GlyceroPhosphoCholine) by AB American Biologics Drug Interactions

Want to check YOUR meds against GPC (GlyceroPhosphoCholine)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

sn-Glycero (3) Phosphocholine 16

Individual Drug Interactions

The ingredients in GPC (GlyceroPhosphoCholine) interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in GPC (GlyceroPhosphoCholine) interact with drugs. Each result below shows which ingredient is responsible. sn-Glycero (3) Phosphocholine

Each ingredient & the kinds of drugs it affects

For each ingredient in GPC (GlyceroPhosphoCholine) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

sn-Glycero (3) Phosphocholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
sn-Glycero (3) Phosphocholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GPC (GlyceroPhosphoCholine), from the product label.

AB American Biologics

See all AB American Biologics products
Name
AMERICAN BIOLOGICS
Street Address
1180 Walnut Ave.
City
Chula Vista
State
CA
ZipCode
91911
Pharmacist Counseling Corner

GPC (GlyceroPhosphoCholine) by AB American Biologics: Common Questions

Does GPC (GlyceroPhosphoCholine) by AB American Biologics interact with any medications?
Yes. Based on its ingredients, GPC (GlyceroPhosphoCholine) has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GPC (GlyceroPhosphoCholine) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC and what does it do?
Alpha-GPC (sn-Glycero(3) Phosphocholine) is a naturally occurring compound that's believed to support brain function and memory. It's the only active ingredient in this product and is marketed for cognitive health.
Does alpha-GPC actually work for memory or brain health?
The evidence varies by use. It's rated possibly effective for Alzheimer disease, meaning some clinical support exists. For cognitive function, brain tumors, vascular dementia, and stroke, the evidence is insufficient — we don't have reliable data yet. Talk with your doctor about what it may or may not do for your specific concern.
Is alpha-GPC safe to take long-term?
While it's generally well tolerated in studies, long-term safety isn't fully established. Importantly, stroke has rarely been reported in people taking alpha-GPC orally for at least two months. This is something you should discuss with your doctor before committing to long-term use.
What side effects might I experience?
Most people tolerate it well. A small number of users have reported dizziness, headache, insomnia, and excitation; others experienced nausea, heartburn, or diarrhea. Stroke is rare but has been documented with long-term use.
Is this safe during pregnancy or breastfeeding?
There isn't enough safety data on file for alpha-GPC during pregnancy or lactation to say either way. Talk with your doctor or pharmacist about whether it's right for you in those situations.
Does this interact with the motion sickness patch?
Yes — alpha-GPC may theoretically weaken the scopolamine patch (Transderm Scop). A small study showed alpha-GPC can offset some effects of scopolamine, though it's unclear how much that matters for the patch's motion sickness benefit. Check with your doctor if you use one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GPC (GlyceroPhosphoCholine) label
Go deeper

The Full Monographs Behind GPC (GlyceroPhosphoCholine)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

GPC (GlyceroPhosphoCholine)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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