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Dietary supplement

Greasewood Ingredients & Drug Interactions

by Pure Herbs

Greasewood label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Greasewood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Greasewood is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for pain and inflammation, skin conditions, antioxidant/general wellness.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chaparral Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Greasewood by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Greasewood by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Greasewood by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Herbs Greasewood contains one active ingredient: chaparral leaf extract. Chaparral has a long history in traditional herbal use, but modern safety data has raised significant concerns about its toxicity to the liver and kidneys.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Chaparral product and its label doesn't state a use — see Chaparral's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold do not include effectiveness ratings for chaparral leaf extract in this form. We cannot say what evidence, if any, supports its use.

The evidence, ingredient by ingredient Chaparral

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chaparral is generally regarded as unsafe for use. Orally, it can cause hepatoxicity (liver damage) with symptoms including jaundice, fatigue, pain in the upper right belly, dark urine, light-colored stools, nausea, diarrhea, weight loss, fever, and loss of appetite.

Serious cases have led to cirrhosis, acute hepatitis, liver failure, and the need for liver transplant. Chaparral can also damage the kidneys.

Topically, it may cause contact dermatitis (skin irritation). The safety data advises against chaparral during pregnancy and while breastfeeding due to toxicity concerns and insufficient safety information.

If you are pregnant, planning pregnancy, or breastfeeding, do not take this product without discussing it first with your doctor or pharmacist.

Side effects, ingredient by ingredient Chaparral

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chaparral.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medication that can damage the liver (hepatotoxic drugs), check with your doctor or pharmacist before adding this product — the chaparral leaf extract carries a moderate interaction risk. Given the serious safety profile of chaparral itself, review any current medications with your healthcare provider before considering this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product carries serious safety concerns. Chaparral has been linked to liver and kidney damage, and in some cases liver failure requiring transplant.

Because of these risks, it is not recommended. If you are taking any medication that affects the liver or kidneys, or if you are pregnant or breastfeeding, do not use this product without explicit guidance from your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Greasewood, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279776
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Greasewood by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Chaparral Leaf Extract1917 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for the occasional upset stomach and to maintain a healthy respiratory system. Beneficial for weight reduction as part of a diet and exercise routine.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Rare reports of serious liver disease have been associated with ingestion of chaparral. Ask a healthcare professional before use if you have or have had liver problems, frequently use alcoholic beverages, or are taking any medication. Stop use and see a doctor if you develop symptoms that may signal liver problems.

Ask a healthcare professional before use if you have or have had liver problems, frequently use alcoholic beverages, or are taking any medication. Not intended for use by pregnant or nursing women.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Greasewood by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Greasewood label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Greasewood by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Chaparral Leaf Extract

Interacts with
370 drugs
1917 mg per serving

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious a...

Chaparral Leaf Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Greasewood by Pure Herbs Drug Interactions

Want to check YOUR meds against Greasewood?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

Chaparral Leaf Extract 370

Individual Drug Interactions

The ingredients in Greasewood interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in Greasewood interact with drugs. Each result below shows which ingredient is responsible. Chaparral Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Greasewood with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chaparral Leaf Extract1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Likelihood Possible Evidence D
Chaparral Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Greasewood, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Greasewood by Pure Herbs: Common Questions

Does Greasewood by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Greasewood has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Greasewood contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is chaparral used for?
Chaparral has a long history in traditional herbal use, but the product facts we hold do not specify what conditions it is intended to treat. Current safety data has raised significant concerns about its toxicity.
Is this safe to take?
Chaparral is generally regarded as unsafe. It can cause serious liver and kidney damage, including liver failure in some cases. The safety data advises against using it. Talk with your doctor or pharmacist before considering it.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against chaparral during pregnancy and while breastfeeding due to toxicity concerns and lack of safety data. Do not use this product if you are pregnant, planning pregnancy, or breastfeeding without explicit guidance from your doctor or pharmacist.
What are the side effects of chaparral?
Chaparral can cause hepatoxicity (liver damage) with symptoms like jaundice, fatigue, upper belly pain, dark urine, light stools, nausea, diarrhea, weight loss, fever, and loss of appetite. Serious cases have led to cirrhosis, acute hepatitis, liver failure, and transplant. It can also damage the kidneys and cause contact dermatitis if applied to skin.
Can I take this with medications that affect my liver?
No. There is a documented moderate interaction between chaparral and hepatotoxic drugs (medications that can affect the liver), and the concern is that chaparral's own liver effects might make the damage worse. Check with your doctor or pharmacist before using this product if you take any medication affecting liver function.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Greasewood label
Go deeper

The Full Monographs Behind Greasewood’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chaparral

Interacts with 370 drugs

Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition. It has been linked to serious and sometimes irreversible liver and kidn...

Read the full Chaparral monograph →
Sources

Sources & How We Checked

Greasewood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaparral 16 references
  1. Smith BC, Desmond PV. Acute hepatitis induced by ingestion of the herbal medication chaparral. Aust N Z J Med 1993;23:526.. PubMed
  2. Gordon DW, Rosenthal G, Hart J, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995;273:489-90.
  3. Batchelor WB, Heathcote J, Wanless IR. Chaparral-induced hepatic injury. Am J Gastroenterol 1995;90:831-3.
  4. Katz M, Saibil F. Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6.
  5. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  6. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997;157:913-9. DOI
  7. Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7:175-85..
  8. Chaparral-induced toxic hepatitis-California and Texas, 1992. MMWR Morb Mortal Wkly Rep 1992;41:812-4.. DOI
  9. Estes JD, Stolpman D, Olyaei A, et al. High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. Arch Surg 2003;138:852-8.. PubMed
  10. Lambert JD, Zhao D, Meyers RO, et al. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40:1701-8.. PubMed
  11. Shasky DR. Contact dermatitis from Larrea tridentata (creosote bush). J Am Acad Dermatol 1986;15:302.. PubMed
  12. Smith AY, Feddersen RM, Gardner KD Jr, Davis CJ Jr. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152:2089-91.. PubMed
  13. Kauma, H., Koskela, R., Makisalo, H., Autio-Harmainen, H., Lehtola, J., and Hockerstedt, K. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand.J Gastroenterol. 2004;39(11):1168-1171. PubMed
  14. Leonforte, J. F. Contact dermatitis from Larrea (creosote bush). J Am Acad.Dermatol. 1986;14(2 Pt 1):202-207. PubMed
  15. Alderman, S., Kailas, S., Goldfarb, S., Singaram, C., and Malone, D. G. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin.Gastroenterol. 1994;19(3):242-247.
  16. Clark, F. Chaparral-induced toxic hepatitis: California and Texas, 1992. MMWR Morb Mortal Wkly Rep. 1992;41:812-814. DOI

See these in context on the Chaparral monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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