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Dietary supplement

Guduchi Powder Ingredients & Drug Interactions

by Herbal Hills

Guduchi Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Guduchi Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Guduchi Powder is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guduchi powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Guduchi Powder by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Guduchi Powder by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Guduchi Powder by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Guduchi Powder contains one active ingredient: guduchi powder (also called Tinospora cordifolia), a plant used in traditional medicine. The product has no added inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Tinospora Cordifolia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: enhance natural immunity.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Coronavirus disease 2019 (COVID-19), Hepatitis, Immune function, Infection resistance — and 1 related terms.
  • The closest evidence on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Asthma, Hepatitis, Coronavirus disease 2019 (COVID-19).

The evidence for guduchi is mixed. Clinical research in adults with type 2 diabetes shows it can reduce fasting blood sugar and a marker of long-term blood sugar control (glycated hemoglobin), making it possibly effective for diabetes.

For other conditions — hay fever, asthma, athletic performance, cancer, and hepatitis — there isn't enough reliable evidence to say whether it works. The data we hold doesn't cover those claims.

The evidence, ingredient by ingredient Tinospora Cordifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, guduchi is generally well tolerated, though some people report headache or nasal pain in trials. The main safety concern is liver injury — it's rare, but serious cases including autoimmune hepatitis, acute hepatitis, worsening existing liver disease, and even acute liver failure have been reported after 42 to 90 days of use.

In one case series, two patients needed a liver transplant and four died. Because of this risk, use it carefully and only under guidance.

Guduchi is not safe in pregnancy — the data advises against it. There also isn't enough reliable safety information to recommend it while breastfeeding, so it's best to avoid it then.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Tinospora Cordifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tinospora Cordifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Guduchi Powder, double-check with your doctor or pharmacist if you take antidiabetes drugs (it may lower blood sugar too much), drugs processed through CYP2D6, CYP2C19, CYP1A2, or CYP2C9 pathways (it may raise their blood levels), or immunosuppressants (it may make them less effective). These are all Moderate-severity concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Guduchi may help with type 2 diabetes, but it can lower blood sugar and interact with a large number of medications, especially those your liver processes and immunosuppressants. It also carries a rare risk of liver injury.

If you take any prescription medications, have diabetes, or have liver concerns, check with your doctor or pharmacist before starting. It's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Guduchi Powder, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8906008269567
Net contents 1 kg
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203606
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Guduchi Powder by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Not Present
Maximum serving Sizes:
3 Not Present
UPC/BARCODE
8906008269567
IngredientAmount% DV
Guduchi powder0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Guduchi, is a shrub which is known to possess a number of wonderful therapeutic values through its use. This herb is considered as health rejuvenator which is widely known for its effectivity in enhancing natural immunity to fight against a number of conditions. It is considered to have antioxidant properties and effective in general debility. It is considered to have antioxidant properties. Considered to possess antiseptic properties. May help to maintain healthy blood sugar level. May support healthy immunity.

Halal India www.Halalindia.com

Suggested/Recommended/Usage/Directions

Dosage: Take 3 gms powder, 1 to 2 times a day or as advised by the physician.

Precautions

Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the physician.

Keep out of reach of children.

Do not use if pouch is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place away from direct sunlight.

FDA Statement of Identity

Ayurvedic Product

General Statements

Mfg. Lic. No.: PD/AYU/002/10 (An ISO 22000:2005 Certified Company) Customer Care : 91 22 28686868 (10 a.m to 6 p.m on weekdays)

Seals/Symbols

ISO Certified Company 22000:2005 Halal India www.Halalindia.com S No. 001548 GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Guduchi Powder by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Guduchi Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Guduchi Powder by Herbal Hills

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Not Present Dosage formPowder Amounts shown are per serving.

Guduchi powder

Interacts with
612 drugs
0 NP per serving

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Ea...

Guduchi powder monograph & interactions
Interaction report

Guduchi Powder by Herbal Hills Drug Interactions

Want to check YOUR meds against Guduchi Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

Guduchi powder 612

Individual Drug Interactions

The ingredients in Guduchi Powder interact with 612 drugs. Click any drug to see the details.

1 of the 1 ingredient in Guduchi Powder interact with drugs. Each result below shows which ingredient is responsible. Guduchi powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Guduchi Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Guduchi powder6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
Guduchi powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Guduchi Powder, from the product label.

Herbal Hills

See all Herbal Hills products
Name
Isha Agro Developers Pvt. Ltd.
Street Address
36A/55AB, Lonavala Co.op. Indl. Est. Ltd.
City
Village - Nangargaon, Lonavala, Pune
State
Maharashtra
Phone Number
91 22 28686868
Web Address
www.herbalhills.in
Pharmacist Counseling Corner

Guduchi Powder by Herbal Hills: Common Questions

Does Guduchi Powder by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Guduchi Powder has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Guduchi Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take guduchi if I have diabetes?
Guduchi has been shown in clinical research to lower blood sugar in people with type 2 diabetes. However, if you're already taking antidiabetes medication, taking guduchi on top of it could lower your blood sugar too much. Talk with your doctor or pharmacist before adding it — they may need to adjust your diabetes medication.
What side effects might I experience?
Most people tolerate guduchi well orally. The most common side effects reported in trials are headache and nasal pain. Rarely, liver injury has been reported after weeks of use — in serious cases, it's led to acute liver failure, liver transplant, or death. This is why careful use under guidance is important.
Is guduchi safe to take while pregnant or breastfeeding?
No — safety has not been established in pregnancy, so it's best avoided if you're pregnant or planning pregnancy. There also isn't enough reliable safety information for breastfeeding, so avoid it then too. Talk with your doctor or pharmacist for personalized advice.
Does guduchi work for conditions other than diabetes?
Clinical evidence is lacking. For hay fever, asthma, athletic performance, cancer, and hepatitis, there isn't enough reliable evidence in our data to say whether it works. Possibly effective for type 2 diabetes is what the data supports.
Why do I need to check my medications before taking this?
Guduchi may interfere with how your liver processes many common drugs and could raise their blood levels, making them stronger than intended. It may also make immunosuppressants less effective and boost the blood-sugar-lowering effect of diabetes medications. Your doctor or pharmacist can check your specific medications and advise whether it's safe to combine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Guduchi Powder label
Go deeper

The Full Monographs Behind Guduchi Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph →
Sources

Sources & How We Checked

Guduchi Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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