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Dietary supplement

Organic Neem Powder Ingredients & Drug Interactions

by Herbal Hills

Organic Neem Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Neem Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Neem Powder is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for skin conditions, dental and gum health, antimicrobial and antiparasitic.Based on those ingredients, 1,013 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Neem powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Neem Powder by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Neem Powder by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Neem Powder by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Organic Neem Powder contains one active ingredient: organic neem powder — the dried leaves of the neem tree, used in traditional Ayurvedic medicine. There are no other active ingredients or inactive fillers listed in this product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Neem's overall clinical evidence instead.

Moderate

Some clinical evidence supports Neem for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dental plaque — rated "Possibly Effective" (Natural Medicines).
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).
  • On file: Lice — rated "Possibly Effective" (Natural Medicines).

Neem is possibly effective for gingivitis (gum inflammation), lice, and dental plaque based on available evidence. For acne and tungiasis (a parasitic skin condition), the evidence is currently insufficient to rate it.

The data we hold doesn't establish how strong these effects are or how they compare to standard treatments.

The evidence, ingredient by ingredient Neem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Neem leaf powder is generally well tolerated when taken by mouth short-term in adults, though high-quality safety studies haven't been done. Topically, it's well tolerated in both children and adults, though a small number of people with sensitive skin have reported contact dermatitis.

Neem oil and seed extracts are different — they can be toxic if swallowed, especially in children, and have caused serious effects including heart rhythm problems and kidney damage in rare cases. Neem may affect fertility and pregnancy and is rated likely unsafe during pregnancy — avoid it if you're pregnant.

There isn't enough safety data for breastfeeding, so it's best avoided then too. If you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or diabetes, talk with your doctor or pharmacist before taking neem, since case reports link it to hemolytic anemia in people with that genetic condition.

Side effects, ingredient by ingredient Neem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Neem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,014 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before adding this product if you take antidiabetes drugs (neem can lower blood sugar), or drugs broken down by liver enzymes CYP3A4, CYP1A2, CYP2C9, or CYP2C8, or medications cleared by the kidney transporter P-glycoprotein. Also mention it if you take immunosuppressants.

These are Moderate-severity interactions based on lab evidence, though they haven't been confirmed in humans yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Neem powder is possibly effective for gum health, lice, and plaque, and it's generally well tolerated when used topically or taken by mouth short-term. If you take any medications — especially diabetes drugs, heart medications, or immunosuppressants — you'll want to check with your doctor or pharmacist first, since neem may affect how your body processes a very wide range of drugs.

Pregnant or breastfeeding? Avoid it.

Run your specific medications through the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Neem Powder, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8904268848256
Net contents 16 Ounce(s); 454 Gram(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 296431
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Neem Powder by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
151
UPC/BARCODE
8904268848256
IngredientAmount% DV
organic Neem powder3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Herbal Hills Back to Nature

General Statements

High Quality Natural Products

Neutral Code: MH/PD/AYU/002/10

Formula

Azadirachta indica

Halal India HIW21081110

Suggested/Recommended/Usage/Directions

Directions for use: Take 3 gms powder, 1 to 2 times a day.

Precautions

Warning: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.

Keep out of reach of children.

Do not use if pouch is broken.

Please consult an expert before use.

Storage

Storage: Store in a cool dry place away from direct sunlight.

Formulation

Being natural product. Colour may vary over time as well as from batch to batch however effectiveness remains same.

Country of Origin: India

India Organic Control IMO NPOP/NAB/003 OneCert Certified Organic USDA Organic In-Bio-152 Indian Agriculture

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

India Organic Control IMO NPOP/NAB/003 OneCert Certified Organic USDA Organic IN-BIO-152 Indian Agriculture QA ICS JAS-ANZ Halal India HIW21081110 GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Neem Powder by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Neem Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Neem Powder by Herbal Hills

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container151 Amounts shown are per serving.

Organic Neem powder

Interacts with
1,013 drugs
3 Gram(s) per serving

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are...

Organic Neem powder monograph & interactions
Interaction report

Organic Neem Powder by Herbal Hills Drug Interactions

Want to check YOUR meds against Organic Neem Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,013Drugs
1,013 Moderate

Ingredients driving the most interactions

organic Neem powder 1,013

Individual Drug Interactions

The ingredients in Organic Neem Powder interact with 1,013 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Neem Powder interact with drugs. Each result below shows which ingredient is responsible. organic Neem powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Neem Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Neem powder7 drug types · 1,013 drugs

Antidiabetes Drugs

Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that neem can lower blood glucose levels in adults with type 2 diabetes, including those already taking metformin.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that neem leaf extract inhibits CYP1A2 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C8 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C8 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP2C9 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that neem leaf methanol extract inhibits CYP3A4 enzymes. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, neem might decrease the effectiveness of immunosuppressants.
Animal research suggests that neem might have immunostimulant effects.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that neem leaf methanol extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.

Likelihood Possible Evidence D
organic Neem powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Neem Powder, from the product label.

Herbal Hills

See all Herbal Hills products
Web Address
www.herbalhillsglobal.com
Pharmacist Counseling Corner

Organic Neem Powder by Herbal Hills: Common Questions

Does Organic Neem Powder by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Organic Neem Powder has a known interaction with 1,013 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Neem Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does neem powder work for acne?
The evidence for acne is currently insufficient — we don't have enough reliable data to say whether it works. Neem is possibly effective for gingivitis, dental plaque, and lice, but acne isn't established yet.
Is neem powder safe to use while pregnant?
No — neem is rated likely unsafe during pregnancy and may affect fertility. If you're pregnant or trying to conceive, avoid it and talk with your doctor or pharmacist about alternatives.
Can I use neem powder while breastfeeding?
There isn't enough safety data to know either way. It's best avoided while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.
What are the side effects of neem powder?
Taken by mouth, neem powder seems to be well tolerated in adults, though serious side effects like heart rhythm problems and kidney damage have been reported rarely. Applied to skin, the most common side effect is contact dermatitis in people with sensitive skin. In children, oral neem oil (not leaf powder) can cause serious harm, so keep it away from kids.
Is this product safe for children?
Neem leaf powder applied to skin is generally well tolerated in children. However, neem oil and seed extracts taken by mouth can cause serious adverse effects in children, so oral use should be avoided. Stick to topical use if you're considering it for a child.
What is neem powder used for?
Neem powder is possibly effective for gum inflammation, dental plaque, and lice. It's also been studied for acne and tungiasis, but the evidence for those uses isn't established yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Neem Powder label
Go deeper

The Full Monographs Behind Organic Neem Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Neem

Interacts with 1,013 drugs

Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes. Some small studies are promising for oral health and skin, but...

Read the full Neem monograph →
Sources

Sources & How We Checked

Organic Neem Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Neem 28 references
  1. Sinniah D, Baskaran G. Margosa oil poisoning as a cause of Reye's syndrome. Lancet 1981;1:487-9. PubMed
  2. Sinniah D, Baskaran G, Looi LM, Leong KL. Reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings. Am J Gastroenterol 1982;77:158-61.
  3. Sinniah R, Sinniah D, Chia LS, Baskaran G. Animal model of margosa oil ingestion with Reye-like syndrome. Pathogenesis of microvesicular fatty liver. J Pathol 1989;159:255-64. PubMed
  4. Lai SM, Lim KW, Cheng HK. Margosa oil poisoning as a cause of toxic encephalopathy. Singapore Med J 1990;31:463-5.
  5. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-45.
  6. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992;14:1187-93. PubMed
  7. Ibrahim IA, Khalid SA, Omer SA, Adam SE. On the toxicology of Azadirachta indica leaves. J Ethnopharmacol 1992;35:267-73. PubMed
  8. Ali BH. Toxicology of Azadirachta indica. J Ethnopharmacol 1994;42:71-2. PubMed
  9. Boeke SJ, Boersma MG, Alink GM, et al. Safety evaluation of neem (Azadirachta indica) derived pesticides. J Ethnopharmacol 2004;94:25-41. PubMed
  10. Abdel-Ghaffar, F. and Semmler, M. Efficacy of neem seed extract shampoo on head lice of naturally infected humans in Egypt. Parasitol.Res 2007;100(2):329-332. PubMed
  11. Reutemann, P. and Ehrlich, A. Neem oil: an herbal therapy for alopecia causes dermatitis. Dermatitis 2008;19(3):E12-E15.
  12. Senanayake, M. P., Rupasinghe, S., and Dissanayake, P. V. Margosa (Kohomba) oil induced toxic encephalopathy following home remedy for intestinal worms. Ceylon Med.J 2009;54(4):140. PubMed
  13. Bhaskar, M. V., Pramod, S. J., Jeevika, M. U., Chandan, P. K., and Shetteppa, G. MR imaging findings of neem oil poisoning. AJNR Am J Neuroradiol. 2010;31(7):E60-E61.
  14. Iyyadurai, R., Surekha, V., Sathyendra, S., Paul, Wilson B., and Gopinath, K. G. Azadirachtin poisoning: a case report. Clin Toxicol.(Phila) 2010;48(8):857-858. PubMed
  15. Sinniah, D., Sinniah, R., Baskaran, G., Pathmanathan, R., Yamashita, F., and Yoshino, M. Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. Acta Paediat PubMed
  16. Balakrishnan, V., Pillai, N. R., and Santhakumari, G. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1986;34(7):536.
  17. Sivashanmugham, R., Bhaskar, N., and Banumathi, N. Ventricular fibrillation and cardiac arrest due to neem leaf poisoning. J.Assoc.Physicians India 1984;32(7):610-611.
  18. Mukherjee, S. and Talwar, G. P. Termination of pregnancy in rodents by oral administration of praneem, a purified neem seed extract. Am J Reprod.Immunol. 1996;35(1):51-56. PubMed
  19. Talwar, G. P., Pal, R., Singh, O., Garg, S., Taluja, V., Upadhyay, S. N., Gopalan, S., Jain, V., Kaur, J., and Sehgal, S. Safety of intrauterine administration of purified neem seed oil (Praneem Vilci) in women & effect of its co-administration with the
  20. Talwar, G. P., Shah, S., Mukherjee, S., and Chabra, R. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): mechanisms involved. Am J Reprod.Immunol. 1997;37(6):485-491. PubMed
  21. Greenblatt DT, Banerjee P, White JM. Allergic contact dermatitis caused by neem oil. Contact Dermatitis. 2012;67(4):242-3. PubMed
  22. Page C, Hawes EM. Haemolytic anaemia after ingestion of Neem (Azadirachta indica) tea. BMJ Case Rep. 2013. pii: bcr2013200890.
  23. Braidy N, Berg J, Clement J, et al. Role of nicotinamide dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes. Antiox Redox Signal 2018.
  24. Jadhav PB. Leucoderma on the lips induced by neem (Azadirachta indica): case series. Clin Exp Dermatol. 2018;43(8):943-6.
  25. Giuggioli D, Lumetti F, Spinella A, et al. Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis. J Int Med Res 2019:300060519882176. Online ahead of print.
  26. Pingali U, Ali MA, Gundagani S, Nutalapati C. Evaluation of the effect of an aqueous extract of Azadirachta indica (neem) leaves and twigs on glycemic control, endothelial dysfunction and systemic inflammation in subjects with type 2 diabetes mellitus - a
  27. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
  28. Amaeze O, Eng H, Horlbogen L, Varma MVS, Slitt A. Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. Eur J Drug Metab Pharmacokinet. 2021;46(3):437-450. PubMed

See these in context on the Neem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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