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Dietary supplement

Gymnema-75 Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Premium

Gymnema-75 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gymnema-75 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gymnema-75 is a dietary supplement by AOR Advanced Orthomolecular Research Premium with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 851 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gymnema-75 by AOR Advanced Orthomolecular Research Premium

Ask about any prescription or over-the-counter medication and we check it for interactions with Gymnema-75 by AOR Advanced Orthomolecular Research Premium — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gymnema-75 by AOR Advanced Orthomolecular Research Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Gymnema sylvestre” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

Gymnema-75 contains one active ingredient: Gymnemic Acids derived from Gymnema sylvestre leaf. The supplement comes in a capsule form with no other active components listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gymnema's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support of healthy blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Glycemic control, Glucose metabolism.
  • The closest evidence on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The evidence we hold shows insufficient reliable data to rate gymnema for diabetes, obesity, prediabetes (impaired glucose tolerance), or metabolic syndrome. While some human and animal research suggests it may lower blood glucose, the overall body of evidence isn't strong enough to establish its effectiveness for these conditions.

The evidence, ingredient by ingredient Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gymnema is generally well tolerated in the short term, though quality varies between products. Two rare but serious cases have been reported: one person developed drug-induced hepatitis (liver inflammation with jaundice and elevated liver enzymes) after drinking gymnema tea three times daily for 10 days, and another developed hepatitis-associated aplastic anemia (a blood-forming disorder).

Because it lowers blood sugar, you'll need to be careful if you're also taking diabetes medications. There isn't enough safety data to know whether gymnema is safe during pregnancy or while breastfeeding—the facts advise against use in both cases until more is known.

Talk with your doctor or pharmacist about whether it's right for you in these situations.

Side effects, ingredient by ingredient Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 852 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Gymnema-75, check with your doctor or pharmacist if you're on any blood sugar–lowering drugs or diabetes medications (Moderate severity)—gymnema enhances their effect and could cause low blood sugar. Also double-check any medications processed by your liver's CYP1A2 or CYP2C9 enzymes (Moderate), or CYP3A4 (Minor), since gymnema can raise or unpredictably shift their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gymnema-75 may be worth considering if you're interested in blood sugar support and have no prescription medications, but the evidence for its effectiveness isn't established in the data we hold. If you take any blood sugar–lowering drug, diabetes medication, or anything processed by your liver, check with your doctor or pharmacist before starting—the interaction risks are real.

Avoid it during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gymnema-75, straight from the product label.

Brand AOR Advanced Orthomolecular Research Premium
Barcode (UPC) 624917083002
Net contents 150 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214638
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gymnema-75 by AOR Advanced Orthomolecular Research Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
150
UPC/BARCODE
624917083002
IngredientAmount% DV
Gymnema sylvestre300 mg--
total Gymnemic Acids225 mg--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Supports healthy blood sugar levels

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Note Herbal extracts will naturally vary in color from one batch to another.

Precautions

Do not use if safety seal is broken

Warning: Do not use if you’re pregnant or lactating. Consult a health care practitioner prior to use if you a have medical condition like diabetes or intestinal disorders or symptoms such as abdominal pain, nausea, vomiting or fever, or if you’re taking any medications.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place

Formula

Discussion: Gymnema-75 is a high-potency standardized extract of Gymnema sylvestre, an herb used in traditional Ayurvedic medicine for support of healthy blood sugar levels and to promote healthy digestion

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule daily with food, 2 hours before or after taking other medications, or as directed by a qualified health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Product of Canada

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gymnema-75 by AOR Advanced Orthomolecular Research Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gymnema-75 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gymnema-75 by AOR Advanced Orthomolecular Research Premium

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Gymnema sylvestre

Interacts with
851 drugs
300 mg per serving

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema sylvestre monograph & interactions

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gymnema-75 by AOR Advanced Orthomolecular Research Premium Drug Interactions

Want to check YOUR meds against Gymnema-75?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
851Drugs
347 Moderate 504 Minor

Ingredients driving the most interactions

Gymnema sylvestre 851

Individual Drug Interactions

The ingredients in Gymnema-75 interact with 851 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gymnema-75 interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre

Each ingredient & the kinds of drugs it affects

For each ingredient in Gymnema-75 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema sylvestre6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema sylvestre full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gymnema-75, from the product label.

AOR Advanced Orthomolecular Research Premium

See all AOR Advanced Orthomolecular Research Premium products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Gymnema-75 by AOR Advanced Orthomolecular Research Premium: Common Questions

Does Gymnema-75 by AOR Advanced Orthomolecular Research Premium interact with any medications?
Yes. Based on its ingredients, Gymnema-75 has a known interaction with 851 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gymnema-75 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gymnema-75 if I'm on diabetes medication?
No—not without talking to your doctor first. Gymnema lowers blood glucose on its own and can boost the effect of diabetes drugs, raising the risk of hypoglycemia (dangerously low blood sugar). Your doctor or pharmacist needs to know you're considering it so they can monitor you and adjust your dose if needed.
Is Gymnema-75 safe during pregnancy or breastfeeding?
There isn't enough safety data, so the guidance is to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're thinking about using it in these situations.
Does Gymnema-75 actually work for blood sugar control?
The evidence we hold is insufficient to establish that it works. While some research suggests gymnema may lower blood glucose, there's not enough reliable data to say it's effective for diabetes, prediabetes, or metabolic syndrome.
What side effects has gymnema caused?
It's generally well tolerated short-term, but two rare cases of serious liver problems have been reported: one person developed hepatitis with jaundice and elevated liver enzymes, and another developed hepatitis-linked blood-forming disorder. These are uncommon, but if you notice jaundice, severe fatigue, or weakness, stop and see your doctor right away.
Why does this product interact with so many medications?
Gymnema can slow how your liver breaks down certain drugs by affecting enzymes like CYP1A2 and CYP2C9. When your liver clears drugs more slowly, their levels can climb in your blood, which changes how they work—and that's why even one ingredient can touch hundreds of medications that rely on those same enzymes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gymnema-75 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gymnema-75 label
Go deeper

The Full Monographs Behind Gymnema-75’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Gymnema-75's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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