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Dietary supplement

Gymnema Gold 500 mg Ingredients & Drug Interactions

by NutriGold

Gymnema Gold 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gymnema Gold 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gymnema Gold 500 mg is a dietary supplement by NutriGold with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 851 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gymnema Gold 500 mg by NutriGold

Ask about any prescription or over-the-counter medication and we check it for interactions with Gymnema Gold 500 mg by NutriGold — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gymnema Gold 500 mg by NutriGold

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Gymnema Gold contains one active ingredient: 500 mg of gymnema leaf extract per capsule. Gymnema has been studied for its effects on blood glucose and weight, though the evidence remains limited.

The capsule itself is made from pullulan (a plant-based material), and rice concentrate is included as an inactive ingredient to fill out the formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gymnema's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Suppress sugar cravings and maintain blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Glycemic control, Glucose metabolism.
  • The closest evidence on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The evidence for gymnema isn't yet established. The data we hold shows insufficient reliable evidence to rate it for diabetes, obesity, prediabetes (impaired glucose tolerance), or metabolic syndrome.

Some research suggests it may help lower blood glucose levels, but the overall body of human evidence isn't strong enough to confirm it works or to say how well it works compared to other approaches.

The evidence, ingredient by ingredient Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gymnema is generally well tolerated in the short term, but quality can vary between products, so you may want to check the brand's reputation. One serious concern is that it can lower blood sugar on its own, which matters if you already take diabetes medications.

Rare cases of liver injury (hepatitis) have been reported in people taking gymnema tea, including weakness, fatigue, jaundice, and elevated liver enzymes—one case developed into a serious condition affecting blood cell production. The safety data is not sufficient for pregnancy or breastfeeding, so it's best avoided during both.

Side effects, ingredient by ingredient Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 852 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gymnema Gold, check with your doctor or pharmacist if you take antidiabetes drugs (blood sugar medications) or any drugs metabolized by your liver enzymes, especially if you're on a heart medication, blood thinner, or antidepressant. The risk of low blood sugar with diabetes medications is real, and gymnema can slow down how your body clears some drugs, raising their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any blood sugar medication, heart drug, or prescription that your liver processes, check with your doctor or pharmacist before adding this supplement—the interaction risk is real and could affect how your medications work. Gymnema hasn't been proven effective for the conditions it's marketed for, and rare but serious liver problems have been reported.

Talk it over with your own healthcare provider to decide if it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gymnema Gold 500 mg, straight from the product label.

Brand NutriGold
Barcode (UPC) 859447002333
Net contents 90 Organic Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 309172
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gymnema Gold 500 mg by NutriGold, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
859447002333
IngredientAmount% DV
Gymnema Leaf Extract500 mg--

Other ingredients: Pullulan Capsule, Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Non-GMO verified, TRU-ID certified, organic Gymnema leaf standardized to gymnemic acids and manufactured without chemical additives for exceptional purity.

Ko Kosher Service

Formulation

Health Benefits: Helps suppress sugar cravings and maintain blood sugar levels already within the normal range.

Non-GMO verified, TRU-ID certified, organic Gymnema leaf standardized to gymnemic acids and manufactured without the use of chemical additives for exceptional purity. Verified free of corn, egg, gluten, milk, peanut, shellfish, and soy allergens by an independent lab. Manufactured without magnesium stearate, stearic acid, silicon dioxide, or chemical preservatives.

Organic & Non-GMO

TRU-ID certified Standardized extract

Certified Vegan vegan.org Vegan

Certified organic by SCS Global Services.

General Statements

To learn more about this product, scan QR code or visit nutrigold.com/item/233

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Certified Vegan vegan.org Certified Authentic TRU-ID USDA Organic Non GMO Project Verified nongmoproject.org Ko Kosher Service

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 capsule 2 to 3 times daily, half an hour before meals, or as directed by a healthcare professional.

Precautions

Caution: Please consult a healthcare professional before taking this supplement if you are pregnant, breastfeeding, or taking any medications.

Keep out of reach of children.

Storage

Store in original container away from moisture and direct sunlight.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gymnema Gold 500 mg by NutriGold label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gymnema Gold 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gymnema Gold 500 mg by NutriGold

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Gymnema Leaf Extract

Interacts with
851 drugs
500 mg per serving Form: Gymnemic Acids

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema Leaf Extract monograph & interactions

Other (inactive) ingredients: Pullulan Capsule, Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gymnema Gold 500 mg by NutriGold Drug Interactions

Want to check YOUR meds against Gymnema Gold 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
851Drugs
347 Moderate 504 Minor

Ingredients driving the most interactions

Gymnema Leaf Extract 851

Individual Drug Interactions

The ingredients in Gymnema Gold 500 mg interact with 851 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gymnema Gold 500 mg interact with drugs. Each result below shows which ingredient is responsible. Gymnema Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gymnema Gold 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema Leaf Extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gymnema Gold 500 mg, from the product label.

NutriGold

Name
NutriGold Inc.
City
Orem
State
UT
ZipCode
84057
Phone Number
(800) 476-3542
Web Address
www.nutrigold.com
Pharmacist Counseling Corner

Gymnema Gold 500 mg by NutriGold: Common Questions

Does Gymnema Gold 500 mg by NutriGold interact with any medications?
Yes. Based on its ingredients, Gymnema Gold 500 mg has a known interaction with 851 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gymnema Gold 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gymnema Gold if I'm on a diabetes medication?
Gymnema can lower blood glucose on its own and may boost the effect of diabetes drugs, raising your risk of low blood sugar (hypoglycemia). Do not start this supplement without checking with your doctor or pharmacist first—they can decide if it's safe for you and whether your medication dose needs adjusting.
Is Gymnema Gold safe to take during pregnancy or while breastfeeding?
No. There isn't enough safety data for gymnema during pregnancy or breastfeeding, so it's best avoided during both. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor before taking any new supplement.
What does gymnema actually do?
Gymnema has been studied for its potential effects on blood glucose, obesity, and prediabetes, but the evidence is currently insufficient to confirm it works for any of these. Some research suggests it may help lower blood sugar, but the human data isn't strong enough yet.
Are there any serious side effects I should know about?
Gymnema is generally well tolerated short-term. However, rare cases of liver injury have been reported—including one that caused jaundice, elevated liver enzymes, and serious blood cell problems—so talk to your doctor right away if you develop fatigue, weakness, yellowing of the skin or eyes, or unusual bruising while taking it.
Does gymnema affect how my liver processes medications?
Yes. Gymnema can inhibit and induce several liver enzymes that break down medications, potentially raising or lowering levels of drugs you take. That's why it's important to check with your doctor or pharmacist before starting it, especially if you're on heart medication, blood thinners, or other prescriptions.
How does the quality of Gymnema Gold compare to other gymnema products?
The facts we hold don't include a comparison to other brands. Quality of gymnema products can vary between manufacturers, so you may want to look up NutriGold's reputation and check whether the product has been tested by a third party.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gymnema Gold 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gymnema Gold 500 mg label
Go deeper

The Full Monographs Behind Gymnema Gold 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Gymnema Gold 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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