Interactions on record — worth a quick check against your medications. Based on 16 of 18 ingredients. Check your meds →

Dietary supplement

Hair, Skin & Nails Ingredients & Drug Interactions

Q: Does Hair, Skin & Nails by Celebrate interact with any medications?

Yes. Based on its ingredients, Hair, Skin & Nails has a known interaction with 871 medications. Use the checker to see how it interacts with a specific drug.

Q: How can one product interact with so many drugs?

Hair, Skin & Nails contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.

Q: Where does this information come from?

The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Q: Can I take this if I'm on blood pressure medication?

Vitamin B6, niacin, and sodium in this product may all theoretically reduce how well blood pressure drugs work or lower your blood pressure further — either way, it's a concern. Talk to your pharmacist or doctor before adding this supplement; they may want to monitor your blood pressure more closely.

Q: Is this safe to take during pregnancy?

Most individual ingredients are likely safe at standard prenatal doses — in fact, several like folic acid and B vitamins are recommended in pregnancy. However, horsetail extract is not recommended during pregnancy due to insufficient safety data, and high doses of niacin should be avoided. Discuss the product with your prenatal care provider before starting.

Q: What are the most common side effects?

Most people tolerate these ingredients well, but the most common side effects are mild: nausea, diarrhea, constipation, abdominal discomfort, and headache. At normal doses, serious side effects are rare. High doses of certain ingredients — especially vitamin B6, niacin, or zinc — carry more risk.

Q: Does this actually work for hair and nails?

Some ingredients like zinc, iron, and B vitamins have solid evidence for correcting deficiencies if you're lacking them. Biotin and lysine have some evidence for specific uses like hair loss or cold sores. For healthy people without a deficiency, whether this product noticeably improves hair, skin, or nails is not well established in the data we hold.

Q: Can I take this with antibiotics?

Iron and zinc both interfere with tetracycline and quinolone antibiotics, reducing how much antibiotic your body absorbs. If you're on one of these antibiotics, take your supplement at least 2–4 hours apart from your antibiotic dose. Check with your pharmacist about the exact timing for your specific antibiotic.

Q: Is there a lot of sodium in this?

The product facts don't specify how much sodium is in each capsule, so you'd need to check the label or ask your pharmacist. If you have high blood pressure or are watching your sodium intake, this is worth confirming before you start.

by Celebrate

See full label image

Capsule Category: Other Combinations

Most serious interaction: Moderate

Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Sep 16, 2026 · Label data from the NIH DSLD

What is this page for?

First and foremost: checking Hair, Skin & Nails against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hair, Skin & Nails is a dietary supplement by Celebrate with 18 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 871 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin, Vitamin B6, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hair, Skin & Nails by Celebrate

Ask about any prescription or over-the-counter medication and we check it for interactions with Hair, Skin & Nails by Celebrate — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds

AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI

Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Hair, Skin & Nails by Celebrate

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure

Ingredient Transparency · database check

Full

Every active ingredient lists its own amount on the label.

Why this rating?

The label discloses an exact amount for 18 of its 18 active ingredients.
“Folate” is listed as a grouped ingredient — the label gives one combined amount (167 mcg DFE) without saying how much of each component you get.

This product contains 18 active ingredients supporting hair, skin, and nail health. The formula includes several B vitamins — B6, B12, thiamine, riboflavin, niacin, pantothenic acid, and folic acid — which play roles in energy and tissue maintenance.

It also contains minerals like zinc, iron, and copper; amino acids including L-lysine; botanical extracts like horsetail; and compounds such as biotin, choline, inositol, and methylsulfonylmethane. There are also small amounts of sodium and para-aminobenzoic acid.

Three inactive ingredients — hypromellose, magnesium stearate, and silica — are used as a capsule shell and binder.

Does it work?

Strong evidence

Evidence for Intended Use · database check

By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?

The label markets this product for: Hair, skin and nails support.
We looked for evidence on: Acne, Androgenic alopecia, Anemia, Atopic dermatitis (eczema), Biotin deficiency, Nail brittleness — and 2 related terms.
The strongest evidence on file: Iron is rated "Effective" for Anemia of chronic disease (Natural Medicines).
Also on file: Iron is rated "Effective" for Iron deficiency anemia.
Also on file: Vitamin B6 is rated "Effective" for Sideroblastic anemia.

The evidence for this product's ingredients varies widely. Zinc, iron, and several B vitamins (B6, B12, thiamine, and folic acid) are effective for correcting their respective deficiencies if one exists.

Biotin is likely effective for biotin deficiency. For other uses, the data is mixed: zinc has possibly effective evidence for acne and age-related macular degeneration; B6 is possibly effective for pregnancy-related nausea; folic acid is possibly effective for depression; and lysine is possibly effective for cold sores.

However, evidence is insufficient or the ingredients are possibly ineffective for many other claimed skin and hair benefits. The strength of any effect on healthy hair, skin, or nails in people without a deficiency is not well established in our data.

The evidence, ingredient by ingredient Vitamin B6 Sodium Riboflavin Biotin Lysine Thiamine Pantothenic Acid Choline

How safe is it?

Well-documented data

Safety Information · database check

Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?

We hold adverse-effect (side-effect) data for 16 of the 16 matched ingredients.
Pregnancy & breastfeeding safety ratings cover 16 of 16.
General safety write-ups exist for 16 of 16.
Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are well tolerated at standard doses. However, several carry cautions.

High-dose vitamin B6 can damage nerves with prolonged use. Niacin at high doses can cause liver problems, flushing, and gastrointestinal upset.

Zinc and iron are safe at recommended amounts but can cause nausea, constipation, or diarrhea; excess zinc over time may lead to copper deficiency. Horsetail contains thiaminase, which can deplete thiamine (vitamin B) with long-term use.

Sodium in excess raises blood pressure and heart strain risk. For pregnancy and breastfeeding, most ingredients are likely safe at standard prenatal or supplement doses, but high-dose niacin and some others should be avoided in pregnancy unless prescribed.

Horsetail is not recommended in pregnancy or while breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Vitamin B6 Sodium Riboflavin Biotin Lysine Thiamine Pantothenic Acid Choline

Meds to double-check

Moderate interaction found

Known Interaction Concern · database check

Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?

14 of the 16 matched ingredients can interact with medications — Lysine, Inositol, Choline, Horsetail, Copper, among others.
The most serious interaction on file is rated Moderate.
Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
For scale: 872 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Major or Moderate interactions exist with seizure medications (phenytoin, phenobarbital), blood pressure drugs, diabetes medications, several antibiotics (tetracyclines, quinolones), HIV antiretrovirals, blood thinners, and methotrexate. Minor interactions exist with levodopa, atropine, and certain other drugs.

If you take any of these medication types, check your exact drugs before use.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient supplement with some ingredients backed by solid evidence (B vitamins and minerals for deficiencies) and others with modest or unclear support for skin and hair health. If you take any prescription medications — especially seizure drugs, blood pressure meds, diabetes drugs, antibiotics, or blood thinners — you should check your specific drugs with the tool on this page before starting.

Talk to your pharmacist or doctor if you're pregnant, breastfeeding, or have a chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 16 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hair, Skin & Nails, straight from the product label.

Brand	Celebrate
Barcode (UPC)	895138002848
Net contents	120 Capsule(s)
Market status	On market
Date entered into DSLD	Aug 22, 2025
DSLD ID	337071
Product type	Other Combinations
Supplement form	Capsule
Dietary claims / uses	All Other, Structure/Function
Intended target group(s)	Adult (18 - 50 Years), Gluten Free

From the label

Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hair, Skin & Nails by Celebrate, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):

Adults and children 4 or more years of age

Minimum serving Sizes:

2 Capsule(s)

Maximum serving Sizes:

2 Capsule(s)

Servings per container

UPC/BARCODE

895138002848

Ingredient	Amount	% DV
Vitamin B6	2 mg	118%
Folic Acid	100 mcg	--
Sodium	25 mg	1%
Riboflavin	12.5 mg	962%
Biotin	1000 mcg	3333%
L-Lysine Hydrochloride	275 mg	--
Thiamine	12.5 mg	1042%
Pantothenic Acid	7.5 mg	150%
Choline	12.5 mg	2%
Niacin	5 mg	31%
Folate	167 mcg DFE	42%
Inositol	25 mg	--
Zinc	7.5 mg	68%
Iron	4 mg	22%
Methylsulfonylmethane	250 mg	--
Vitamin B12	50 mcg	2083%
Para-Aminobenzoic Acid	25 mg	--
Copper	0.5 mg	56%
Horsetail Aerial Parts Extract	175 mg	--

Other ingredients: Hypromellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements

These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.

Suggested/Recommended/Usage/Directions

Directions: Take two capsules in the morning and two in the evening or as directed by a healthcare professional, as a dietary supplement.

Precautions

Do not use if safety seal is broken.

Keep out of reach of small children. Warning: Accidental overdose of iron containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten-free

Seals/Symbols

GMP Good Manufacturing Practice Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hair, Skin & Nails by Celebrate label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)

What’s inside

The Ingredients in Hair, Skin & Nails by Celebrate

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs

2 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs

25 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Riboflavin

Interacts with
20 drugs

12.5 mg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Biotin

No known
interactions

1000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

L-Lysine Hydrochloride

Interacts with
1 drug

275 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

Thiamine

Interacts with
3 drugs

12.5 mg per serving Form: Thiamine Mononitrate

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Pantothenic Acid

No known
interactions

7.5 mg per serving Form: D-Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Choline

Interacts with
16 drugs

12.5 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Niacin

Interacts with
727 drugs

5 mg per serving Form: Niacinamide

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Folate

167 mcg DFE per serving

› Folic Acid

Inositol

Interacts with
86 drugs

25 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Inositol monograph & interactions

Zinc

Interacts with
67 drugs

7.5 mg per serving Form: Zinc Bisglycinate Chelate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Iron

Interacts with
80 drugs

4 mg per serving Form: Ferrous Fumarate

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Methylsulfonylmethane

250 mg per serving

Vitamin B12

Interacts with
20 drugs

50 mcg per serving Form: Cyanocobalamin, Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Para-Aminobenzoic Acid

25 mg per serving

Copper

Interacts with
31 drugs

0.5 mg per serving Form: Copper Bisglycinate Chelate

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Horsetail Aerial Parts Extract

Interacts with
188 drugs

175 mg per serving Form: Silica

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. I...

Horsetail Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

HelloPharmacist.com · Pharmacist card

Hair, Skin & Nails

by Celebrate · label dated Aug 22, 2025

Scan for the full live report

Known drug interactions: 871 medications — most serious rated moderate

Active ingredients

Vitamin B6, Sodium, Riboflavin, Biotin, L-Lysine Hydrochloride, Thiamine, Pantothenic Acid, Choline, Niacin, Folate, Inositol, Zinc, …

Most serious documented interactions

6-Mercaptopurine — Moderate (via Niacin)
Abacavir Sulfate, Dolutegravir, Lamivudine — Moderate (via Niacin)
Abacavir, Lamivudine — Moderate (via Horsetail Aerial Parts Extract)

Full interaction list, ingredient monographs & live checker: https://hellopharmacist.com/drug-supplement-interactions/supplements/hair-skin-nails-by-celebrate-5296110
Printed · Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

Interaction report

Hair, Skin & Nails by Celebrate Drug Interactions

Hair, Skin & Nails — Celebrate · HelloPharmacist interaction report
Active ingredients: Vitamin B6, Sodium, Riboflavin, Biotin, L-Lysine Hydrochloride, Thiamine, Pantothenic Acid, Choline, Niacin, Folate, Inositol, Zinc, Iron, Methylsulfonylmethane, Vitamin B12, …
Source label: Aug 22, 2025 · Printed · HelloPharmacist.com
Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

HelloPharmacist Interaction Report

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Last generated Jul 11, 2026

18 active ingredients 14 with known interactions 871 medications covered

Celebrate Hair, Skin & Nails contains 18 ingredients, many of which interact with medications.

The most serious interaction is with vitamin B6 and phenobarbital or phenytoin (seizure medications) — high doses of B6 can reduce levels of these drugs and make them less effective at controlling seizures.

Read the full breakdown — every affected drug type, severity by severity

Several ingredients affect blood pressure control. Vitamin B6, niacin, and sodium can all theoretically reduce how well antihypertensive drugs work.

Niacin and vitamin B6 may also lower blood pressure on their own, which could cause dizziness or weakness if you're already on blood-pressure medication.

Other significant interactions span antibiotics, HIV medications, diabetes drugs, and blood thinners. Iron and zinc both reduce absorption of tetracycline and quinolone antibiotics — you'd need to space them hours apart.

Inositol and horsetail may lower blood sugar and could amplify the effect of diabetes medications. Zinc and iron interact with multiple antiretroviral drugs used for HIV.

Niacin can reduce the effect of blood thinners and increase bleeding risk. Altogether, these interactions span 853 individual medications.

Check your exact medications with the search tool below before starting this product.

Check your own medications below · Editorial policy · How we use AI

Want to check YOUR meds against Hair, Skin & Nails?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker

871Drugs

845 Moderate 26 Minor

Ingredients driving the most interactions

Niacin 727

Vitamin B6 210

Sodium 205

Horsetail Aerial Parts Extract 188

Inositol 86

Individual Drug Interactions

The ingredients in Hair, Skin & Nails interact with 871 drugs. Click any drug to see the details.

14 of the 18 ingredients in Hair, Skin & Nails interact with drugs. Each result below shows which ingredient is responsible. Niacin Vitamin B6 Sodium Horsetail Aerial Parts Extract Inositol Iron Zinc Folic Acid Copper Riboflavin Vitamin B12 Choline Thiamine L-Lysine Hydrochloride

All interactions 871 Moderate 845 Minor 26

Showing 1–30 of 871 drugs.

6-mercaptopurinePurinethol

Moderate

6-mercaptopurine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How 6-mercaptopurine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + 6-mercaptopurine interaction

See the 6-mercaptopurine drug page: uses, dosage & side effects

Abacavir Sulfate, Dolutegravir, LamivudineTriumeq

Moderate

Abacavir Sulfate, Dolutegravir, Lamivudine belongs to Hepatotoxic DrugsNucleoside Reverse Transcriptase Inhibitors (nrtis) — the drug categories that interact with this product

How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Hair, Skin & Nails — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abacavir Sulfate, Dolutegravir, Lamivudine interaction

Horsetail Aerial Parts ExtractNucleoside Reverse Transcriptase Inhibitors (nrtis) Moderate

Interaction Summary

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.

Read the full Horsetail Aerial Parts Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interaction

See the Abacavir Sulfate, Dolutegravir, Lamivudine drug page: uses, dosage & side effects

Abacavir, LamivudineEpzicom

Moderate

Abacavir, Lamivudine belongs to Nucleoside Reverse Transcriptase Inhibitors (nrtis)Hepatotoxic Drugs — the drug categories that interact with this product

How Abacavir, Lamivudine interacts with Hair, Skin & Nails — through 2 ingredients. Tap an ingredient for the detail:

Horsetail Aerial Parts ExtractNucleoside Reverse Transcriptase Inhibitors (nrtis) Moderate

Interaction Summary

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.

Read the full Horsetail Aerial Parts Extract + Abacavir, Lamivudine interaction

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abacavir, Lamivudine interaction

AbciximabReoPro

Moderate

Abciximab belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Abciximab interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Abciximab interaction

Abiraterone

Moderate

Abiraterone belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abiraterone interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abiraterone interaction

See the Abiraterone drug page: uses, dosage & side effects

Abiraterone AcetateYonsa, Zytiga

Moderate

Abiraterone Acetate belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abiraterone Acetate interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abiraterone Acetate interaction

See the Abiraterone Acetate drug page: uses, dosage & side effects

AbrocitinibCibinqo

Moderate

Abrocitinib belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Abrocitinib interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Abrocitinib interaction

See the Abrocitinib drug page: uses, dosage & side effects

AcarboseGlucobay, Prandase, Precose

Moderate

Acarbose belongs to Antidiabetes DrugsHepatotoxic Drugs — the drug categories that interact with this product

How Acarbose interacts with Hair, Skin & Nails — through 3 ingredients. Tap an ingredient for the detail:

NiacinAntidiabetes Drugs, Hepatotoxic Drugs Moderate

Interaction Summary

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Niacin + Acarbose interaction

InositolAntidiabetes Drugs Moderate

Interaction Summary

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Acarbose interaction

Horsetail Aerial Parts ExtractAntidiabetes Drugs Moderate

Interaction Summary

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Horsetail Aerial Parts Extract + Acarbose interaction

See the Acarbose drug page: uses, dosage & side effects

AcebutololRhotral, Sectral

Moderate

Acebutolol belongs to Hepatotoxic DrugsAntihypertensive Drugs — the drug categories that interact with this product

How Acebutolol interacts with Hair, Skin & Nails — through 3 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs, Antihypertensive Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acebutolol interaction

SodiumAntihypertensive Drugs Moderate

Interaction Summary

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full Sodium + Acebutolol interaction

Vitamin B6Antihypertensive Drugs Moderate

Interaction Summary

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full Vitamin B6 + Acebutolol interaction

See the Acebutolol drug page: uses, dosage & side effects

AcenocoumarolSintrom

Moderate

Acenocoumarol belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Acenocoumarol interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Acenocoumarol interaction

AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength

Moderate

Acetaminophen belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen interaction

See the Acetaminophen drug page: uses, dosage & side effects

Acetaminophen, AspirinGemnisyn

Moderate

Acetaminophen, Aspirin belongs to Hepatotoxic DrugsAnticoagulant/antiplatelet DrugsAspirin — the drug categories that interact with this product

How Acetaminophen, Aspirin interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs +1 Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Aspirin interaction

Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine

Moderate

Acetaminophen, Aspirin, Caffeine belongs to AspirinAnticoagulant/antiplatelet DrugsHepatotoxic Drugs — the drug categories that interact with this product

How Acetaminophen, Aspirin, Caffeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinAspirin, Anticoagulant/antiplatelet Drugs +1 Moderate

Interaction Summary

Large doses of aspirin might alter the clearance of niacin.

Read the full Niacin + Acetaminophen, Aspirin, Caffeine interaction

Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu

Moderate

Acetaminophen, Brompheniramine, Phenylpropanolamine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction

Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more

Moderate

Acetaminophen, Butalbital belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Butalbital interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital interaction

Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more

Moderate

Acetaminophen, Butalbital, Caffeine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Butalbital, Caffeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Caffeine interaction

See the Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects

Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine

Moderate

Acetaminophen, Butalbital, Caffeine, Codeine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Caffeine, Codeine interaction

Acetaminophen, Butalbital, CodeineBancap w/ Codeine

Moderate

Acetaminophen, Butalbital, Codeine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Butalbital, Codeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Codeine interaction

Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3

Moderate

Acetaminophen, Butalbital, Codeine Phosphate belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Butalbital, Codeine Phosphate interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Codeine Phosphate interaction

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound

Moderate

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction

Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more

Moderate

Acetaminophen, Caffeine, Codeine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Caffeine, Codeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Codeine interaction

Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3

Moderate

Acetaminophen, Caffeine, Codeine, Salicylamide belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Codeine, Salicylamide interaction

Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS

Moderate

Acetaminophen, Caffeine, Dihydrocodeine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Caffeine, Dihydrocodeine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Dihydrocodeine interaction

Acetaminophen, Caffeine, IsomethepteneMigralam

Moderate

Acetaminophen, Caffeine, Isometheptene belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Caffeine, Isometheptene interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Isometheptene interaction

Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual

Moderate

Acetaminophen, Caffeine, Pyrilamine belongs to Hepatotoxic DrugsDiuretic Drugs — the drug categories that interact with this product

How Acetaminophen, Caffeine, Pyrilamine interacts with Hair, Skin & Nails — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Pyrilamine interaction

Horsetail Aerial Parts ExtractDiuretic Drugs Moderate

Interaction Summary

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Read the full Horsetail Aerial Parts Extract + Acetaminophen, Caffeine, Pyrilamine interaction

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief

Moderate

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction

Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex

Moderate

Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction

Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu

Moderate

Acetaminophen, Chlorpheniramine, Dextromethorphan belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction

Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu

Moderate

Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction

Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief

Moderate

Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Hair, Skin & Nails — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction

Each ingredient & the kinds of drugs it affects

For each ingredient in Hair, Skin & Nails with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D

Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D

Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B

Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B

Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D

Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D

Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D

Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D

Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D

Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D

Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D

Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B

Niacin full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B

Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B

Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D

Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D

Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D

Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A

Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D

Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C

Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B

Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

Sodium full monograph & interactions

Horsetail Aerial Parts Extract5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D

Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D

Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D

Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D

Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D

Horsetail Aerial Parts Extract full monograph & interactions

Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A

Inositol full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D

Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D

Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D

Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B

Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D

Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B

Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B

Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B

Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D

Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D

Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D

Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D

Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D

Iron full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D

Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B

Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D

Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D

Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B

Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B

Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B

Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B

Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B

Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B

Zinc full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D

Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D

Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B

Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B

Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B

Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B

Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D

Folic Acid full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D

Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D

Copper full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D

Riboflavin full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A

Vitamin B12 full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D

Choline full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B

Thiamine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D

L-Lysine Hydrochloride full monograph & interactions

The maker

Brand information

Manufacturer and brand details for Hair, Skin & Nails, from the product label.

Celebrate

See all Celebrate products

Name: Celebrate Vitamins
Street Address: 516 Corporate Pkwy
City: Wadsworth
State: OH
ZipCode: 44281
Phone Number: 877-424-1953
Web Address: CelebrateVitamins.com

Pharmacist Counseling Corner

Hair, Skin & Nails by Celebrate: Common Questions

Does Hair, Skin & Nails by Celebrate interact with any medications?

Yes. Based on its ingredients, Hair, Skin & Nails has a known interaction with 871 medications. Use the checker to see how it interacts with a specific drug.

How can one product interact with so many drugs?

Hair, Skin & Nails contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.

Where does this information come from?

The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Can I take this if I'm on blood pressure medication?

Vitamin B6, niacin, and sodium in this product may all theoretically reduce how well blood pressure drugs work or lower your blood pressure further — either way, it's a concern. Talk to your pharmacist or doctor before adding this supplement; they may want to monitor your blood pressure more closely.

Is this safe to take during pregnancy?

Most individual ingredients are likely safe at standard prenatal doses — in fact, several like folic acid and B vitamins are recommended in pregnancy. However, horsetail extract is not recommended during pregnancy due to insufficient safety data, and high doses of niacin should be avoided. Discuss the product with your prenatal care provider before starting.

What are the most common side effects?

Most people tolerate these ingredients well, but the most common side effects are mild: nausea, diarrhea, constipation, abdominal discomfort, and headache. At normal doses, serious side effects are rare. High doses of certain ingredients — especially vitamin B6, niacin, or zinc — carry more risk.

Does this actually work for hair and nails?

Some ingredients like zinc, iron, and B vitamins have solid evidence for correcting deficiencies if you're lacking them. Biotin and lysine have some evidence for specific uses like hair loss or cold sores. For healthy people without a deficiency, whether this product noticeably improves hair, skin, or nails is not well established in the data we hold.

Can I take this with antibiotics?

Iron and zinc both interfere with tetracycline and quinolone antibiotics, reducing how much antibiotic your body absorbs. If you're on one of these antibiotics, take your supplement at least 2–4 hours apart from your antibiotic dose. Check with your pharmacist about the exact timing for your specific antibiotic.

Is there a lot of sodium in this?

The product facts don't specify how much sodium is in each capsule, so you'd need to check the label or ask your pharmacist. If you have high blood pressure or are watching your sodium intake, this is worth confirming before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hair, Skin & Nails is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Go deeper

The Full Monographs Behind Hair, Skin & Nails’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph →

Sources

Sources & How We Checked

Hair, Skin & Nails's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 469 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references

Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Folic Acid 56 references

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.
Ortiz Z, Shea B, Suarez Almazor M, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Cochrane Database Syst Rev 2000;2:CD000951. PubMed
Van Delden C, Hirschel B. Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome (letter). J Infect Dis 1996;173:1294-5. PubMed
Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7. PubMed
Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
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Sodium 38 references

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Riboflavin 5 references

Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
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Biotin 4 references

Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
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Lysine 7 references

Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
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Thiamine 7 references

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
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Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

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Pantothenic Acid 11 references

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D. M., Elias, P. M., Fritsch, P. O., and Fritsch, E. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br.J.Dermatol. 2 PubMed
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Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. PubMed
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Choline 14 references

Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
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Niacin 66 references

Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
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Inositol 14 references

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Morii M., Ueno K., Ogawa A., Kato R., Yoshimura H., Wada K., Hashimoto H., Takada M., Tanaka K., Nakatani T., Shibakawa M. Impairment of mycophenolate mofetil absorption by iron ion. Clin Pharmacol Ther 2000;68(6):613-616. PubMed
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El-Hawy MA, Abd Al-Salam SA, Bahbah WA. Comparing oral iron bisglycinate chelate, lactoferrin, lactoferrin with iron and iron polymaltose complex in the treatment of children with iron deficiency anemia. Clin Nutr ESPEN 2021;46:367-371. PubMed
Adams A, Scheckel B, Habsaoui A, et al. Intravenous iron versus oral iron versus no iron with or without erythropoiesis- stimulating agents (ESA) for cancer patients with anaemia: a systematic review and network meta-analysis. Cochrane Database Syst Rev 2 PubMed
Kancherla K, Constantin H, Kanawati A, Graham E. Iron-induced Hypophosphatemic Osteomalacia-An Atypical Case of Bilateral Femoral Stress Fractures. J Am Acad Orthop Surg Glob Res Rev 2023;7(5):e22. PubMed
Shi R, Marin JG, Beaulieu M. Skin staining following intravenous iron extravasation in a patient with chronic kidney disease: A case report. Can J Kidney Health Dis 2023;10:20543581231165705. PubMed
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Jara Vidal M, López García MC, Quílez Toboso RP. Kounis syndrome after intravenous iron administration. Med Clin (Barc) 2023. DOI
Jara Vidal M, Ruiz de Assín Valverde A, Aznar Rodríguez S. Severe hypophospathemia secondary to intravenous iron. Med Clin (Barc) 2023. DOI
Samões B, Silva B, Martins A, et al. Hypophosphatemic osteomalacia induced by intravenous iron therapy: a case report. Joint Bone Spine 2023;90(5):105586. PubMed
Seng NW, Barco JB, Wong MH, et al. Hypophosphatemia related to intravenous iron therapy with ferric carboxymaltose: A case series. Transfus Med 2023. PubMed
Fernandez-Flores A, Fernandez-Parrado M, Alzoghby-Abi Chaker J, Angulo AG. Axillary cutaneous hemosiderosis in a patient with hyperhidrosis, after intravenous iron infusion. Am J Dermatopathol 2023;45(7):463-465. PubMed
Ye S, Grill V, Luo J, Nguyen HH. Concurrent Denosumab and Parenteral Iron Therapy Precipitating Severe Hypocalcemia and Hypophosphatemia. JCEM Case Rep 2024;2(2):luae005. PubMed
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Meyers M, Salmon M, Libert I, Klá&scaron;terský J. A meta-analysis on the risk of infection associated with intravenous iron therapy in cancer-associated anaemia: a double-edged sword?. Curr Opin Oncol 2024;36(4):223-232. PubMed
Short V, Allen R, Earley CJ, et al. A randomized double-blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia. Am J Hem PubMed
Bellos I, Frountzas M, Pergialiotis V. Comparative Risk of Hypophosphatemia Following the Administration of Intravenous Iron Formulations: A Network Meta-Analysis. Transfus Med Rev 2020;34(3):188-194. PubMed
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Vitamin B12 30 references

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
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Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
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Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
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Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

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Copper 11 references

Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

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Horsetail 14 references

Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
Revilla MC, Andrade-Cetto A, Islas S, Wiedenfeld H. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. J Ethnopharmacol 2002;81:117-20. PubMed
Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol.Nefrol.(Mosk) 1983;3(1):47-50.
Henderson JA, Evans EV, and McIntosh RA. The antithiamine action of Equisetum. J Amer Vet Med Assoc 1952;120:375-378.
Carneiro DM, Freire RC, Honório TC, Zoghaib I, Cardoso FF, Tresvenzol LM, de Paula JR, Sousa AL, Jardim PC, da Cunha LC. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Voluntee
Klnçalp S, Ekiz F, Basar Ö, Coban S, Yüksel O. Equisetum arvense (Field Horsetail)-induced liver injury. Eur J Gastroenterol Hepatol. 2012 Feb;24(2):213-4. PubMed
Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E, Claudio L. Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep. 2011 M PubMed
Cordova E, Morganti L, Rodriguez C. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail (Equisetum arvense) and Antiretroviral Drugs. J Int Assoc Provid AIDS Care. 2017;16(1):11-13.
García Gavilán MD, Moreno García AM, Rosales Zabal JM, Navarro Jarabo JM, Sánchez Cantos A. Case of drug-induced acute pancreatitis produced by horsetail infusions. Rev Esp Enferm Dig. 2017 Apr;109(4):301-304. PubMed
Vieira GT, de Oliveira TT, Carneiro MAA, et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. PubMed
Health Canada. Organism-Equisetum arvense. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq.do?id=6117&lang=eng. Accessed 21-July 2021.
Bates D, Duong TB, Kheyson S, Moore K. Hyponatremia Secondary to Decreased Oral Intake and SIADH and Possibly Exacerbated by Horsetail (Equisetum arvense). Can J Hosp Pharm 2021;74(4):386-389. PubMed

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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Hair, Skin & Nails Ingredients & Drug Interactions

Check Your Meds Against Hair, Skin & Nails by Celebrate

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Supplement Facts

Supplement Facts

Hair, Skin & Nails by Celebrate label

The Ingredients in Hair, Skin & Nails by Celebrate

Folate

Methylsulfonylmethane

Para-Aminobenzoic Acid

Hair, Skin & Nails by Celebrate Drug Interactions

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Ingredients driving the most interactions

Individual Drug Interactions

Each ingredient & the kinds of drugs it affects

Niacin15 drug types · 727 drugs

Vitamin B65 drug types · 210 drugs

Sodium7 drug types · 205 drugs

Horsetail Aerial Parts Extract5 drug types · 188 drugs

Inositol1 drug type · 86 drugs

Iron13 drug types · 80 drugs

Zinc10 drug types · 67 drugs

Folic Acid7 drug types · 40 drugs

Copper2 drug types · 31 drugs

Riboflavin1 drug type · 20 drugs

Vitamin B121 drug type · 20 drugs

Choline1 drug type · 16 drugs

Thiamine1 drug type · 3 drugs

L-Lysine Hydrochloride1 drug type · 1 drug

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The Full Monographs Behind Hair, Skin & Nails’s Ingredients

Vitamin B6

Sodium

Riboflavin

Biotin

Lysine

Thiamine

Pantothenic Acid

Choline

Niacin

Folic Acid

Inositol

Zinc

Iron

Vitamin B12

Copper

Horsetail

Sources & How We Checked

The 469 references behind this product’s interaction data