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Dietary supplement

Hawaiian Astaxanthin 12 mg Ingredients & Drug Interactions

by BioAstin

Hawaiian Astaxanthin 12 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hawaiian Astaxanthin 12 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hawaiian Astaxanthin 12 mg is a dietary supplement by BioAstin with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hawaiian Astaxanthin 12 mg by BioAstin

Ask about any prescription or over-the-counter medication and we check it for interactions with Hawaiian Astaxanthin 12 mg by BioAstin — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hawaiian Astaxanthin 12 mg by BioAstin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

BioAstin contains one active ingredient: astaxanthin 12 mg per softgel, a natural carotenoid from algae. The softgel also includes high oleic safflower oil, gelatin, glycerin, purified water, and vitamin E as inactive ingredients to deliver and preserve the astaxanthin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune, eye, skin, joint, cardiovascular health and exercise recovery.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging skin, Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Heart failure — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Athletic performance, Heart failure, Exercise-induced muscle soreness, and more.

The evidence for astaxanthin isn't established in the data we hold. The product is marketed for concerns including age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome, but our monograph rates all of these as insufficient reliable evidence—meaning the research so far hasn't been strong enough to confirm whether it works for any of them.

The evidence, ingredient by ingredient Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported are abdominal pain, diarrhea, and red or orange-colored stools—which is simply the natural color of the compound passing through.

At the 12 mg dose in this product, side effects have been mild, though higher doses (40 mg daily) have caused severe stomach pain in a small number of users. There isn't enough safety data in pregnancy, so the evidence advises against using this product if you're pregnant.

The same applies while breastfeeding—not enough data to know either way, so talk with your doctor or pharmacist before taking it during lactation.

Side effects, ingredient by ingredient Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking BioAstin, check with your doctor or pharmacist if you take any medications metabolized by CYP3A4 or CYP2B6 enzymes. These are Moderate-severity interactions in which astaxanthin may lower drug levels and reduce effectiveness.

The effect is theoretical based on lab research and hasn't been reported in people, but it's worth confirming your exact medications aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

BioAstin may appeal to you if you're looking for an astaxanthin supplement and want a straightforward single-ingredient product. However, if you take medications processed through CYP3A4 or CYP2B6 enzymes—a large category that includes many common drugs—you'll need to check those specific medications with your pharmacist or doctor before adding this.

Pregnant people and those breastfeeding should also discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hawaiian Astaxanthin 12 mg, straight from the product label.

Brand BioAstin
Barcode (UPC) 732894400399
Net contents 75 Soft Gel(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 295249
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hawaiian Astaxanthin 12 mg by BioAstin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
75
UPC/BARCODE
732894400399
IngredientAmount% DV
Calories5 Calorie(s)--
Calories from Fat5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Astaxanthin, Natural12 mg--

Other ingredients: High Oleic Safflower Oil, Gelatin, Glycerin, Water, Purified, Vitamin E

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Human clinical studies have demonstrated Astaxanthin's support for: Immune health Eye health Skin health during UV/Sun exposure Joint health Cardiovascular health Recovery from exercise

Made with Non-GMO Project Verified BioAstin Natural Astaxanthin.

General Statements

Setting the standard for microalgae since 1984

Made with Aloha.

Precautions

Consult your healthcare practitioner before use if you are pregnant or nursing.

Do not use if outer seal is broken.

Formulation

Free of soy, gluten, lactose, yeast, corn & wheat. Pesticide, herbicide, & BSE free. No artificial colors. Made with Non-GMO Project Verified BioAstin Natural Astaxanthin.

USP has tested and verified ingredients, potency, and manufacturing processes. USP sets official standards for dietary supplements. See www.uspverified.org

Nature's powerful antioxidant for immune, eye, skin & joint health

Naturally grown on our farm at Keahole Point in Hawaii since 1990.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2020 Nutrex Hawaii

Farm grown for your wellbeing since 1984

Seals/Symbols

IGEN Non-GMO tested Glyphosate Residue Free detoxfreeproject.org Certified Gluten Free GFCO.org (Gluten-Free Certification Organization) Informed Choice We Test You Trust Regularly Tested for Banned Substances USP Verified Dietary Supplement

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 per day

Suggested use: One soft gel daily with food, BioAstin is best absorbed when taken with food or meal that contains fat. Results are usually seen within 2 to 6 weeks of daily use.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hawaiian Astaxanthin 12 mg by BioAstin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hawaiian Astaxanthin 12 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hawaiian Astaxanthin 12 mg by BioAstin

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container75 Amounts shown are per serving.

Astaxanthin, Natural

Interacts with
671 drugs
12 mg per serving Form: Haematococcus pluvialis

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin, Natural monograph & interactions

Other (inactive) ingredients: High Oleic Safflower Oil, Gelatin, Glycerin, Water, Purified, Vitamin E. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hawaiian Astaxanthin 12 mg by BioAstin Drug Interactions

Want to check YOUR meds against Hawaiian Astaxanthin 12 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin, Natural 671

Individual Drug Interactions

The ingredients in Hawaiian Astaxanthin 12 mg interact with 671 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hawaiian Astaxanthin 12 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Hawaiian Astaxanthin 12 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin, Natural2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hawaiian Astaxanthin 12 mg, from the product label.

BioAstin

See all BioAstin products
Name
Nutrex Hawaii Inc.
City
Kailua-Kona
State
HI
ZipCode
96740
Phone Number
800-453-1187
Web Address
nutrex-hawaii.com
Pharmacist Counseling Corner

Hawaiian Astaxanthin 12 mg by BioAstin: Common Questions

Does Hawaiian Astaxanthin 12 mg by BioAstin interact with any medications?
Yes. Based on its ingredients, Hawaiian Astaxanthin 12 mg has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hawaiian Astaxanthin 12 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is astaxanthin and why is it in this product?
Astaxanthin is a natural carotenoid (a plant pigment) that the product is marketed for its potential antioxidant and anti-aging properties. It's claimed to support cognitive health, eye health, skin health, and athletic performance, among other uses—though our data shows evidence for these uses isn't established yet.
Will this supplement cause red or orange stool?
Yes, red or orange-colored stools are a common and harmless side effect—that's just the natural color of astaxanthin passing through your body. It's not dangerous, just the supplement doing what it does.
Is astaxanthin safe to take during pregnancy or while breastfeeding?
There isn't enough safety data to know either way. The evidence advises against it during both pregnancy and breastfeeding, so talk with your doctor or pharmacist before taking this if you're pregnant or nursing.
Does astaxanthin actually work for aging skin, memory, or athletic performance?
Our data shows insufficient reliable evidence to rate it for any of these uses—meaning the research hasn't been strong enough yet to confirm whether it works. That doesn't mean it doesn't; it means we don't have good evidence either way.
What are the inactive ingredients in this softgel?
The softgel is made with high oleic safflower oil, gelatin, glycerin, purified water, and vitamin E. These help deliver and preserve the astaxanthin—they're not active ingredients in the formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hawaiian Astaxanthin 12 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hawaiian Astaxanthin 12 mg label
Go deeper

The Full Monographs Behind Hawaiian Astaxanthin 12 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Hawaiian Astaxanthin 12 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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