Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Head Comfort Bymygra Ingredients & Drug Interactions

by Market America

Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Head Comfort Bymygra is a dietary supplement by Market America with 4 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 992 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew Flower Extract, Butterbur Root Extract, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Head Comfort Bymygra by Market America

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Head Comfort Bymygra has 4 active ingredients. Riboflavin is a B vitamin your body uses for energy and cell health.

Aquamin is a mineral source we don't have interaction data for. Butterbur root extract and feverfew flower extract are herbal ingredients traditionally used for headaches and inflammation.

The capsule also contains inactive ingredients — hypromellose, microcrystalline cellulose, stearic acid, silicon dioxide, and magnesium stearate — which are binders, thickeners, and flow agents that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy cognitive function and blood flow to head.
  • We looked for evidence on: Migraine headache, Tension headache, Headache, Cerebral blood flow, Head pain.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Migraine headache (Natural Medicines).
  • Also on file: Feverfew is rated "Insufficient Reliable Evidence To Rate" for Tension headache.

Butterbur root extract is possibly effective for migraine headaches and allergic rhinitis (hay fever). Feverfew flower extract has insufficient evidence to rate it for tension headaches, and the evidence for other uses — including skin conditions and rheumatoid arthritis — is also insufficient.

Riboflavin has no effectiveness ratings on file. The evidence supporting this product's overall use isn't established in the data we hold.

The evidence, ingredient by ingredient Riboflavin Butterbur Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Riboflavin is generally well tolerated; excess is removed in urine. It may cause dose-related nausea and bright yellow urine at high doses.

Butterbur must be a pyrrolizidine alkaloid (PA)-free standardized product, because raw butterbur can damage the liver. Common side effects from butterbur include belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset.

Feverfew is generally well tolerated short-term but may cause mouth irritation, abdominal pain, bloating, diarrhea, constipation, heartburn, and nausea. Stopping feverfew after long-term use may trigger "post-feverfew syndrome" — anxiety, headaches, and insomnia.

Riboflavin is likely safe in pregnancy and lactation at recommended doses; ask your provider about higher doses. Butterbur is likely unsafe in pregnancy and lactation.

Feverfew is possibly unsafe in pregnancy and lacks enough safety data for breastfeeding — avoid both.

Side effects, ingredient by ingredient Riboflavin Butterbur Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Butterbur, Feverfew, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 993 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications against our tool if you take blood thinners or antiplatelet drugs (feverfew may increase bleeding risk), drugs broken down by your liver through CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP2C8, or CYP3A4 pathways (feverfew may raise their levels), CYP3A4 inducers (butterbur may increase toxicity), or tetracycline antibiotics (riboflavin may reduce potency).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for headache support, with butterbur and feverfew as the main active ingredients. If you take any regular medications — especially blood thinners, antidepressants, heart drugs, or antibiotics — you need to check them against the interaction tool before starting.

Pregnant or breastfeeding? Talk to your doctor or pharmacist first, especially regarding the butterbur and feverfew.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Head Comfort Bymygra, straight from the product label.

Brand Market America
Barcode (UPC) 848570011152
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298789
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Head Comfort Bymygra by Market America, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
848570011152
IngredientAmount% DV
Riboflavin400 mcg31%
Aquamin150 mg36%
Butterbur Root Extract150 mg--
Feverfew Flower Extract150 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes healthy cognitive function Helps maintain normal blood flow to the head and neck

Vegan

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: Adults over 18 years of age, take 2 capsules daily. May be taken with or without food.

Precautions

Warning: If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. If you are pregnant or breastfeeding, do not take this product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.

Brand IP Statement(s)

As AquaMin Mg. AquaMin is a registered trademark of Marigot, Ltd.

See for yourself

Head Comfort Bymygra by Market America label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Head Comfort Bymygra by Market America

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Riboflavin

Interacts with
20 drugs
400 mcg per serving

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Aquamin

150 mg per serving Form: Magnesium

Butterbur Root Extract

Interacts with
87 drugs
150 mg per serving Form: Petasin

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Butterbur Root Extract monograph & interactions

Feverfew Flower Extract

Interacts with
929 drugs
150 mg per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew Flower Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Head Comfort Bymygra by Market America Drug Interactions

Want to check YOUR meds against Head Comfort Bymygra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
992Drugs
992 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Head Comfort Bymygra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew Flower Extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Butterbur Root Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Head Comfort Bymygra, from the product label.

Market America

See all Market America products
Name
Market America, Inc.
Street Address
1302 Pleasant Ridge Road
City
Greensboro
State
NC
ZipCode
27409
Pharmacist Counseling Corner

Head Comfort Bymygra by Market America: Common Questions

Does Head Comfort Bymygra by Market America interact with any medications?
Yes. Based on its ingredients, Head Comfort Bymygra has a known interaction with 992 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Head Comfort Bymygra contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is butterbur root extract for?
Butterbur is possibly effective for migraine headaches and allergic rhinitis (hay fever). It's one of the main active ingredients in this product.
Is this safe to take while pregnant?
Butterbur and feverfew are likely unsafe or possibly unsafe in pregnancy — the safety data advises against them. Riboflavin is likely safe at recommended doses, but ask your doctor or pharmacist for personalized advice before starting this product.
Can I breastfeed while taking this?
Butterbur is likely unsafe while breastfeeding, and there isn't enough safety data on feverfew to recommend it. Talk to your doctor or pharmacist before use if you're nursing.
What side effects should I expect?
Riboflavin may cause dose-related nausea and bright yellow urine. Butterbur commonly causes belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, and stomach upset. Feverfew may cause abdominal pain, bloating, diarrhea, constipation, heartburn, and nausea. Stopping feverfew after long-term use may trigger anxiety, headaches, and insomnia.
What is Aquamin?
Aquamin is one of the ingredients in this product, but we don't have interaction or effectiveness data on file for it. Your pharmacist may be able to tell you more.
Does this product have fillers?
Yes, it contains inactive ingredients — hypromellose, microcrystalline cellulose, stearic acid, silicon dioxide, and magnesium stearate — that act as binders and flow agents in the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Head Comfort Bymygra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Head Comfort Bymygra label
Sources

Sources & How We Checked

Head Comfort Bymygra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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