Head Comfort Bymygra Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Head Comfort Bymygra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Head Comfort Bymygra is a dietary supplement by Market America with 4 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 992 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew Flower Extract, Butterbur Root Extract, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Head Comfort Bymygra by Market America
Ask about any prescription or over-the-counter medication and we check it for interactions with Head Comfort Bymygra by Market America — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Head Comfort Bymygra by Market America
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Head Comfort Bymygra has 4 active ingredients. Riboflavin is a B vitamin your body uses for energy and cell health.
Aquamin is a mineral source we don't have interaction data for. Butterbur root extract and feverfew flower extract are herbal ingredients traditionally used for headaches and inflammation.
The capsule also contains inactive ingredients — hypromellose, microcrystalline cellulose, stearic acid, silicon dioxide, and magnesium stearate — which are binders, thickeners, and flow agents that hold the capsule together.
Does it work?
Moderate evidence
Butterbur root extract is possibly effective for migraine headaches and allergic rhinitis (hay fever). Feverfew flower extract has insufficient evidence to rate it for tension headaches, and the evidence for other uses — including skin conditions and rheumatoid arthritis — is also insufficient.
Riboflavin has no effectiveness ratings on file. The evidence supporting this product's overall use isn't established in the data we hold.
How safe is it?
Well-documented data
Riboflavin is generally well tolerated; excess is removed in urine. It may cause dose-related nausea and bright yellow urine at high doses.
Butterbur must be a pyrrolizidine alkaloid (PA)-free standardized product, because raw butterbur can damage the liver. Common side effects from butterbur include belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset.
Feverfew is generally well tolerated short-term but may cause mouth irritation, abdominal pain, bloating, diarrhea, constipation, heartburn, and nausea. Stopping feverfew after long-term use may trigger "post-feverfew syndrome" — anxiety, headaches, and insomnia.
Riboflavin is likely safe in pregnancy and lactation at recommended doses; ask your provider about higher doses. Butterbur is likely unsafe in pregnancy and lactation.
Feverfew is possibly unsafe in pregnancy and lacks enough safety data for breastfeeding — avoid both.
Meds to double-check
Moderate interaction found
Before taking this product, check your exact medications against our tool if you take blood thinners or antiplatelet drugs (feverfew may increase bleeding risk), drugs broken down by your liver through CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP2C8, or CYP3A4 pathways (feverfew may raise their levels), CYP3A4 inducers (butterbur may increase toxicity), or tetracycline antibiotics (riboflavin may reduce potency).
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is designed for headache support, with butterbur and feverfew as the main active ingredients. If you take any regular medications — especially blood thinners, antidepressants, heart drugs, or antibiotics — you need to check them against the interaction tool before starting.
Pregnant or breastfeeding? Talk to your doctor or pharmacist first, especially regarding the butterbur and feverfew.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Head Comfort Bymygra, straight from the product label.
| Brand | Market America |
|---|---|
| Barcode (UPC) | 848570011152 |
| Net contents | 60 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 298789 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Head Comfort Bymygra by Market America, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Riboflavin | 400 mcg | 31% |
| Aquamin | 150 mg | 36% |
| Butterbur Root Extract | 150 mg | -- |
| Feverfew Flower Extract | 150 mg | -- |
Other ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Promotes healthy cognitive function Helps maintain normal blood flow to the head and neck
Vegan
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for use: Adults over 18 years of age, take 2 capsules daily. May be taken with or without food.
Precautions
Warning: If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. If you are pregnant or breastfeeding, do not take this product.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.
Brand IP Statement(s)
As AquaMin Mg. AquaMin is a registered trademark of Marigot, Ltd.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Head Comfort Bymygra by Market America label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Head Comfort Bymygra by Market America
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Riboflavin
Interacts with20 drugs
Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...
Riboflavin monograph & interactionsAquamin
Butterbur Root Extract
Interacts with87 drugs
Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...
Butterbur Root Extract monograph & interactionsFeverfew Flower Extract
Interacts with929 drugs
Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...
Feverfew Flower Extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Head Comfort Bymygra by Market America Drug Interactions
HelloPharmacist Interaction Report
Head Comfort Bymygra by Market America contains four ingredients, three of which we've checked for interactions with medications.
The most serious interaction involves feverfew flower extract, which may theoretically increase levels of drugs metabolized by several liver enzymes (CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP2C8, and CYP3A4 substrates) — all rated Moderate severity. Additionally, feverfew may have additive bleeding effects with blood thinners and antiplatelet drugs (Moderate).
Butterbur root extract theoretically may increase the toxicity of CYP3A4 inducers (Moderate severity). Riboflavin carries a Moderate interaction with tetracycline antibiotics, as it may theoretically decrease their potency, though this has not been reported in humans.
We could not check Aquamin for interactions — no data is on file for it.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 978 individual medications. Because so many enzyme substrates exist, it's important you run your exact medications through the interaction checker on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Head Comfort Bymygra?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Head Comfort Bymygra interact with 992 drugs. Click any drug to see the details.
3 of the 4 ingredients in Head Comfort Bymygra interact with drugs. Each result below shows which ingredient is responsible. Feverfew Flower Extract Butterbur Root Extract Riboflavin
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Feverfew Flower Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Feverfew Flower Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Feverfew Flower Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Feverfew Flower Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew Flower Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Head Comfort Bymygra — through 1 ingredient. Tap an ingredient for the detail:
Feverfew Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Read the full Feverfew Flower Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Head Comfort Bymygra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Feverfew Flower Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.
Butterbur Root Extract
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.
Riboflavin
Tetracycline Antibiotics
Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Head Comfort Bymygra, from the product label.
Market America
See all Market America products- Name
- Market America, Inc.
- Street Address
- 1302 Pleasant Ridge Road
- City
- Greensboro
- State
- NC
- ZipCode
- 27409
Head Comfort Bymygra by Market America: Common Questions
Does Head Comfort Bymygra by Market America interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is butterbur root extract for?
Is this safe to take while pregnant?
Can I breastfeed while taking this?
What side effects should I expect?
What is Aquamin?
Does this product have fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Head Comfort Bymygra is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Head Comfort Bymygra’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Riboflavin
Interacts with 20 drugsRiboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...
Read the full Riboflavin monograph → Herb & supplement monographButterbur
Interacts with 87 drugsButterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...
Read the full Butterbur monograph → Herb & supplement monographFeverfew
Interacts with 929 drugsFeverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...
Read the full Feverfew monograph →Sources & How We Checked
Head Comfort Bymygra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Riboflavin 5 references
- Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
- MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
- Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.
Butterbur 7 references
- Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
- Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
- Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
- Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
- Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
- Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
- Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed
Feverfew 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
- Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
- Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
- Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
- Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
- Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
- Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
- Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
- Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
- Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
- Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
- Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
- Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
- Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
- Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC