Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Herbal Biotic Ingredients & Drug Interactions

by Return Healthy

Herbal Biotic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herbal Biotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Herbal Biotic is a dietary supplement by Return Healthy with 8 active ingredients. Its ingredients are commonly taken for immune support, viral infections (such as herpes or colds), antibacterial support.Based on those ingredients, 1,185 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove bud essential oil, Uncaria tomentosa extract, Oregano Essential Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Herbal Biotic by Return Healthy

Ask about any prescription or over-the-counter medication and we check it for interactions with Herbal Biotic by Return Healthy — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Herbal Biotic by Return Healthy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,810 mg) without saying how much of each component you get.

Herbal Biotic is an 8-ingredient capsule built around a proprietary blend of herbal extracts. The active ingredients include monolaurin (a fatty acid from coconut), cat's claw extract, isatis extract, houttuynia extract, scuttellaria extract, oregano essential oil, and clove bud essential oil.

The blend also contains inactive ingredients — cellulose, L-leucine, and silicon dioxide — which serve as capsule material and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: build immune function and support normal microbial levels.
  • We looked for evidence on: Respiratory tract infections, Upper respiratory tract infection (URTI), Bronchitis, Cough, Intestinal parasite infection, Bacterial vaginosis — and 4 related terms.
  • The closest evidence on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Cough (Natural Medicines).
  • Also on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Gingivitis, Oral mucositis.
  • Also on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Upper respiratory tract infection (URTI), Cough, Gingivitis.

The evidence for effectiveness is limited across the board. Cat's claw and isatis are rated as having insufficient reliable evidence for the conditions studied (hay fever, Alzheimer's, asthma, osteoporosis, cancer, chronic fatigue for cat's claw; psoriasis, respiratory infections, prostate cancer, ulcerative colitis, hepatitis, aging skin for isatis — though isatis is rated possibly effective for psoriasis).

Monolaurin, oregano, and clove all carry insufficient evidence ratings for their stated uses (bacterial vaginosis for monolaurin; acne, bronchitis, asthma, headache, upper respiratory infection for oregano; cough, pain, dyspepsia for clove). Clove is rated possibly effective for ventilator-associated pneumonia in hospitalized patients, but that's a specialized clinical setting.

None of these ingredients have strong proof they work for the typical reasons someone might buy an herbal biotic product.

The evidence, ingredient by ingredient Monolaurin Cat's Claw Isatis Oregano Clove

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients carry pregnancy cautions. Monolaurin is rated likely safe in pregnancy, but cat's claw, oregano, and isatis are all rated possibly unsafe or should be avoided — cat's claw because of traditional use as an abortifacient, oregano and isatis due to lack of safety data.

For breastfeeding, monolaurin and oregano suggest caution (lauric acid is natural in breast milk, but supplement safety isn't confirmed; oregano food amounts are fine but medicinal doses aren't studied), while cat's claw and isatis are best avoided. Cat's claw has rare but documented case reports of kidney injury linked to its use; one patient developed acute kidney failure and another developed acute interstitial nephritis requiring prednisone treatment — both improved when the product was stopped.

In clinical trials, cat's claw caused anemia in 12% of participants and leukopenia and thrombocytopenia each in 2%, though those patients had advanced cancer and confounding is possible. Oregano and clove can cause allergic reactions in sensitive people; oregano has triggered anaphylaxis, and clove oil in doses as small as 5–10 mL can be toxic in children.

Side effects, ingredient by ingredient Monolaurin Cat's Claw Isatis Oregano Clove

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Clove, Cat's Claw, Oregano.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,186 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before combining with blood pressure medications (antihypertensives) or calcium channel blockers — cat's claw may cause dangerous drops in blood pressure (Moderate). Also flag diabetes medications and blood thinners or antiplatelet drugs with your doctor — oregano and cat's claw may trigger low blood sugar or increased bleeding (Moderate).

If you take drugs metabolized by liver enzymes CYP3A4, CYP2D6, CYP1A2, or CYP2C9, clove may raise their levels (Moderate). Finally, if you're on the antiviral nirmatrelvir/ritonavir (Paxlovid), cat's claw may reduce its effectiveness (Moderate).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking blood pressure medications, diabetes drugs, blood thinners, immunosuppressants, or certain antivirals like Paxlovid, you'll need to clear this product with your doctor or pharmacist first — the interaction risks are real and documented. For anyone else, the bigger question is whether it actually works; the evidence doesn't support strong effectiveness claims.

Talk with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or have a history of kidney problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herbal Biotic, straight from the product label.

Brand Return Healthy
Barcode (UPC) 019962468605
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 313314
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herbal Biotic by Return Healthy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
Servings per container
40
UPC/BARCODE
019962468605
IngredientAmount% DV
Proprietary Blend1810 mg--
Monolaurin0 NP--
Uncaria rhynchophylla Extract0 NP--
Uncaria tomentosa extract0 NP--
Isatis tinctoria Extract0 NP--
Houttuynia cordata Extract0 NP--
Scuttellaria baicalensis Extract0 NP--
Oregano Essential Oil0 NP--
Clove bud essential oil0 NP--

Other ingredients: Cellulose, L-Leucine, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1-3 capsules 2-3 times per day, with or without meals, or as directed by your health care practitioner, as a dietary supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.

Precautions

Caution: Individuals who are pregnant or lactating should consult with their health care practitioner before using this product.

Do not use if security seal is broken or missing.

Keep out of reach of children.

Storage

Store in cool dry place away from direct light.

Formulation

Build immune function, supports normal microbial levels.

This product contains no hidden, excipients, binders, fillers, artificial colors, fragrance, wheat, gluten, dairy, corn, fish, egg, shellfish, animal derivatives, tree nuts or peanuts.

FDA Statement of Identity

Dietary Supplement

General Statements

Return Healthy Empowered Wellness

For more information, visit ReturnHealthy.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herbal Biotic by Return Healthy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herbal Biotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herbal Biotic by Return Healthy

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1810 mg per serving

Other (inactive) ingredients: Cellulose, L-Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herbal Biotic by Return Healthy Drug Interactions

Want to check YOUR meds against Herbal Biotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,185Drugs
1,185 Moderate

Ingredients driving the most interactions

Clove bud essential oil 979
Uncaria tomentosa extract 964
Oregano Essential Oil 208

Individual Drug Interactions

The ingredients in Herbal Biotic interact with 1,185 drugs. Click any drug to see the details.

3 of the 8 ingredients in Herbal Biotic interact with drugs. Each result below shows which ingredient is responsible. Clove bud essential oil Uncaria tomentosa extract Oregano Essential Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Herbal Biotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove bud essential oil7 drug types · 979 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove bud essential oil full monograph & interactions

Uncaria tomentosa extract6 drug types · 964 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Uncaria tomentosa extract full monograph & interactions

Oregano Essential Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oregano Essential Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Herbal Biotic, from the product label.

Return Healthy

See all Return Healthy products
Name
Return Healthy LLC
Street Address
3143 S 840 E, Suite #342
City
St George
State
Utah
ZipCode
84790-8547
Phone Number
(435) 624-1329
Web Address
ReturnHealthy.com
Pharmacist Counseling Corner

Herbal Biotic by Return Healthy: Common Questions

Does Herbal Biotic by Return Healthy interact with any medications?
Yes. Based on its ingredients, Herbal Biotic has a known interaction with 1,185 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herbal Biotic contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Most ingredients in this product are not well studied in pregnancy or while breastfeeding. Cat's claw, oregano, and isatis are all rated as possibly unsafe or best avoided during pregnancy; cat's claw and isatis should also be avoided while breastfeeding. Monolaurin is rated likely safe in pregnancy but caution is advised while breastfeeding. Talk with your doctor or pharmacist before use — this is a personal decision that depends on your individual health.
What is monolaurin and what does it do?
Monolaurin is a fatty acid derived from coconut that's sometimes used for bacterial vaginosis, though the evidence for it is not reliable enough to rate. It's generally well tolerated in food-related amounts, but human safety data for supplement use are limited.
What is cat's claw used for in this formula?
Cat's claw (Uncaria tomentosa extract) is included for conditions like allergic rhinitis, asthma, and chronic fatigue, but there's not enough reliable evidence to confirm it works for any of these. It's been traditionally used, and it does interact with a significant number of medications, so it requires careful consideration before use.
Can oregano and clove essential oils cause allergic reactions?
Yes — both can trigger allergic reactions in sensitive people. Oregano has caused serious allergic responses including anaphylaxis in rare cases. Clove oil in high doses can be toxic, especially in children; as little as 5–10 mL has caused harm. These are concentrated oils, not food amounts.
Are there any serious side effects I should know about?
Cat's claw has case reports of kidney injury leading to acute kidney failure and acute inflammation of the kidney tissue, both improving after the product was stopped. In trials, it caused anemia in 12% of users and low blood cell counts in 2% (though those patients had advanced cancer). Clove oil and oregano are safe as food spices but concentrated supplements carry more risk.
Does this product actually work as an herbal biotic?
The evidence doesn't strongly support it. Most ingredients — cat's claw, oregano, clove, monolaurin, and the others — are rated as having insufficient reliable evidence for their listed uses. Clove is possibly effective for ventilator-associated pneumonia in hospitalized patients, but that's a very specific clinical setting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herbal Biotic label
Go deeper

The Full Monographs Behind Herbal Biotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Monolaurin

Monolaurin is a compound made from lauric acid, a fatty acid found in coconut oil and breast milk, and it is marketed mostly for immune and antimicrobial support. While laboratory studies su...

Read the full Monolaurin monograph → Herb & supplement monograph

Cat's Claw

Interacts with 964 drugs

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...

Read the full Cat's Claw monograph → Herb & supplement monograph

Isatis

Isatis is a plant long used in traditional Chinese medicine, mainly for sore throats, fevers, and colds. Modern evidence in people is very limited, so its benefits are not well proven. Talk...

Read the full Isatis monograph → Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph → Herb & supplement monograph

Clove

Interacts with 979 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph →
Sources

Sources & How We Checked

Herbal Biotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 59 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Monolaurin 2 references
  1. FDA, Center for Food Safety and Applied Nutrition, Office of Premarket Approval, EAFUS: A food additive database. Website: vm.cfsan.fda.gov/~dms/eafus.html (Accessed 23 February 2006).
  2. Mancuso AC, Widdice LE, Hughes BL, et al. Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial. J Low Genit Tract Dis. 2020 Jul;24(3):277-283. PubMed

See these in context on the Monolaurin monograph →

Cat's Claw 16 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  4. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
  5. Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
  6. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
  7. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
  8. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  9. Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
  10. Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
  11. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
  12. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
  13. Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
  14. De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
  15. Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
  16. Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed

See these in context on the Cat's Claw monograph →

Isatis 3 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

See these in context on the Isatis monograph →

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  5. Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
  6. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  7. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
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  10. Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
  11. Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Clove 26 references
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See these in context on the Clove monograph →

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