Interactions on record — worth a quick check against your medications. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

Cryptolepis Synergy Ingredients & Drug Interactions

by Return Healthy

Cryptolepis Synergy label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cryptolepis Synergy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cryptolepis Synergy is a dietary supplement by Return Healthy with 9 active ingredients. Its ingredients are commonly taken for sore throat and cough, digestive upset, skin irritation.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eupatorium Perfolatum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cryptolepis Synergy by Return Healthy

Ask about any prescription or over-the-counter medication and we check it for interactions with Cryptolepis Synergy by Return Healthy — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Cryptolepis Synergy by Return Healthy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This 9-ingredient formula combines traditional herbal components. The active ingredients are Salvia miltiorrhiza, Cryptolepis sanguinolenta, Sida acuta, Bidens pilosa, Ceanothus americanus, Eupatorium Perfolatum (Boneset), Chenopodium ambrosioides, Copaiba Balsam Essential Oil, and Alchornea cordifolia.

The capsules also contain cellulose and rice concentrate as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting these ingredients' effectiveness is not established in the data we hold. Boneset, Sida acuta (Mallow), Copaiba Balsam, and Ceanothus americanus (New Jersey Tea) all show insufficient reliable evidence to rate them for their traditional uses — meaning claims about their benefits haven't been backed by solid research.

You're essentially exploring traditional uses without confirmed modern evidence.

The evidence, ingredient by ingredient Mallow New Jersey Tea Boneset Copaiba Balsam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several safety concerns warrant attention. Boneset contains potentially liver-toxic alkaloids and should be used cautiously and only short-term; liver damage is possible at high doses.

Sida acuta (Mallow) and Copaiba Balsam are generally well tolerated for short-term use, but human safety data are limited. Copaiba Balsam, especially in doses of 5 grams or more, can cause stomach pain, vomiting, and diarrhea.

Sida acuta may cause diarrhea, indigestion, nausea, or vomiting. Ceanothus americanus (New Jersey Tea) has little modern safety data, so caution and professional guidance are advised.

Pregnancy and breastfeeding: The safety data advise against Boneset, Sida acuta, Copaiba Balsam, and Ceanothus americanus during pregnancy and breastfeeding — there isn't enough data on the other three ingredients to advise either way, so discuss them with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Mallow New Jersey Tea Boneset Copaiba Balsam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Boneset.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication class to check is CYP3A4 inducers — drugs that speed up liver enzyme activity, such as carbamazepine. If you take any anticonvulsant, some antibiotics, rifampin, or other enzyme inducers, run them through the search tool on this page before starting.

No other specific medication types are documented to interact with the ingredients we were able to check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a complex herbal blend whose individual ingredients lack solid modern evidence for effectiveness. If you take carbamazepine or other CYP3A4-inducing medications, or if you have liver concerns, talk to your pharmacist or doctor before starting.

Pregnant or breastfeeding? Several ingredients aren't recommended — check with your healthcare provider.

For anyone else considering it, use short-term only and under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cryptolepis Synergy, straight from the product label.

Brand Return Healthy
Barcode (UPC) 787790578512
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313309
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cryptolepis Synergy by Return Healthy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
787790578512
IngredientAmount% DV
Salvia miltiorrhiza125 mg--
Cryptolepis sanguinolenta750 mg--
Sida acuta250 mg--
Bidens pilosa250 mg--
Ceanothus americanus125 mg--
Eupatorium Perfolatum125 mg--
Chenopodium ambrosioides125 mg--
Copaiba Balsam Essential Oil20 mg--
Alchornea cordifolia250 mg--

Other ingredients: Cellulose, Rice Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules 2 times a day, or as directed by your health care practitioner, as a dietary supplement. Can be taken with or without food.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.

Precautions

Caution: Individuals who are pregnant or lactating should consult with their health care practitioner before using this product.

Do not use if security seal is broken or missing.

Keep out of reach of children.

Storage

Store in a cool dry place away from direct light.

General Statements

For more information, visit ReturnHealthy.com

Return Healthy by Dr. Vosloo

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cryptolepis Synergy by Return Healthy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cryptolepis Synergy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cryptolepis Synergy by Return Healthy

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Salvia miltiorrhiza

125 mg per serving

Cryptolepis sanguinolenta

750 mg per serving

Sida acuta

No known
interactions
250 mg per serving

Mallow (Malva sylvestris) is a traditional herb valued for its soothing, mucilage-rich leaves and flowers, used mostly for sore throat, cough, and min...

Sida acuta monograph & interactions

Bidens pilosa

250 mg per serving

Ceanothus americanus

No known
interactions
125 mg per serving

New Jersey Tea is a North American shrub whose leaves were historically brewed as a caffeine-free tea and used in folk medicine for sore throats and o...

Ceanothus americanus monograph & interactions

Eupatorium Perfolatum

Interacts with
87 drugs
125 mg per serving

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains comp...

Eupatorium Perfolatum monograph & interactions

Chenopodium ambrosioides

125 mg per serving

Copaiba Balsam Essential Oil

No known
interactions
20 mg per serving

Copaiba balsam is a resin from South American Copaifera trees, valued in traditional medicine and now popular as an essential oil and supplement, main...

Copaiba Balsam Essential Oil monograph & interactions

Alchornea cordifolia

250 mg per serving

Other (inactive) ingredients: Cellulose, Rice Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cryptolepis Synergy by Return Healthy Drug Interactions

Want to check YOUR meds against Cryptolepis Synergy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Eupatorium Perfolatum 87

Individual Drug Interactions

The ingredients in Cryptolepis Synergy interact with 87 drugs. Click any drug to see the details.

1 of the 9 ingredients in Cryptolepis Synergy interact with drugs. Each result below shows which ingredient is responsible. Eupatorium Perfolatum

Each ingredient & the kinds of drugs it affects

For each ingredient in Cryptolepis Synergy with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Eupatorium Perfolatum1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs). Hepatotoxic PAs are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Eupatorium Perfolatum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cryptolepis Synergy, from the product label.

Return Healthy

See all Return Healthy products
Name
Return Healthy LLC
Street Address
230 N. 1680 E. Suite [-]
City
St. George
State
UT
ZipCode
84790
Phone Number
435-624-1329
Web Address
ReturnHealthy.com
Pharmacist Counseling Corner

Cryptolepis Synergy by Return Healthy: Common Questions

Does Cryptolepis Synergy by Return Healthy interact with any medications?
Yes. Based on its ingredients, Cryptolepis Synergy has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cryptolepis Synergy contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Not without talking to your doctor first. Boneset, Sida acuta (Mallow), and Copaiba Balsam are not recommended during pregnancy or breastfeeding due to limited safety data. We don't have enough safety information on the other ingredients to advise either way, so a conversation with your healthcare provider is important before taking this product.
Does Boneset in this formula actually work for colds?
The evidence isn't established in our data. Boneset is traditionally used for colds, but we don't hold reliable evidence backing that claim. It's an unproven traditional remedy.
What are the most common side effects I should watch for?
Sida acuta (Mallow) and Boneset can both cause nausea, vomiting, and diarrhea. Copaiba Balsam may cause diarrhea or stomach pain, especially at higher doses. Keep an eye out for these, and stop if they're bothersome.
Why can't you check all the ingredients for drug interactions?
We don't hold interaction data (monographs) for Salvia miltiorrhiza, Cryptolepis sanguinolenta, Bidens pilosa, or Chenopodium ambrosioides. That doesn't mean they're safe with all medications — it just means we can't confirm one way or the other.
Is this formula safe for long-term use?
No. Boneset especially should be used cautiously and short-term only because it contains potentially liver-toxic alkaloids. Sida acuta and Copaiba Balsam are also described as generally well tolerated for short-term use with limited long-term safety data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cryptolepis Synergy is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cryptolepis Synergy label
Go deeper

The Full Monographs Behind Cryptolepis Synergy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mallow

Mallow (Malva sylvestris) is a traditional herb valued for its soothing, mucilage-rich leaves and flowers, used mostly for sore throat, cough, and minor skin or stomach irritation. Scientifi...

Read the full Mallow monograph → Herb & supplement monograph

New Jersey Tea

New Jersey Tea is a North American shrub whose leaves were historically brewed as a caffeine-free tea and used in folk medicine for sore throats and other complaints. There is very little mo...

Read the full New Jersey Tea monograph → Herb & supplement monograph

Boneset

Interacts with 87 drugs

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may...

Read the full Boneset monograph → Herb & supplement monograph

Copaiba Balsam

Copaiba balsam is a resin from South American Copaifera trees, valued in traditional medicine and now popular as an essential oil and supplement, mainly for inflammation and skin concerns. H...

Read the full Copaiba Balsam monograph →
Sources

Sources & How We Checked

Cryptolepis Synergy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mallow 2 references
  1. Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30-3. PubMed
  2. Elsagh M, Fartookzadeh MR, Kamalinejad M, et al. Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105-11. PubMed

See these in context on the Mallow monograph →

New Jersey Tea 1 reference
  1. Herbs at a Glance — NIH NCCIH Source

See these in context on the New Jersey Tea monograph →

Boneset 5 references
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

See these in context on the Boneset monograph →

Copaiba Balsam 2 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Copaiba Balsam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team