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Dietary supplement

Hesperidin Methyl Chalcone 500 mg Ingredients & Drug Interactions

by Doctor's Best

Hesperidin Methyl Chalcone 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hesperidin Methyl Chalcone 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hesperidin Methyl Chalcone 500 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 702 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hesperidin Methyl Chalcone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hesperidin Methyl Chalcone 500 mg by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Hesperidin Methyl Chalcone 500 mg by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hesperidin Methyl Chalcone 500 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: hesperidin methyl chalcone, a bioflavonoid (a type of plant compound) at 500 mg per capsule. Hesperidin is a flavonoid found naturally in citrus fruits.

The capsule also contains inactive ingredients — cellulose, hypromellose, and magnesium stearate — which help form and deliver the supplement.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hesperidin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support vein capillary and circulatory health.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Venous leg ulcers, varicose veins, vascular integrity, leg swelling.
  • The closest evidence on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Hesperidin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Varicose veins, Venous leg ulcers.

The evidence for hesperidin methyl chalcone is limited. For obesity and high cholesterol, the data suggests it's possibly ineffective — meaning studies haven't shown it works for those purposes.

For nonalcoholic fatty liver disease, there isn't enough reliable evidence to say either way. If you're considering this supplement for any of these uses, talk with your doctor about whether it's right for you.

The evidence, ingredient by ingredient Hesperidin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hesperidin methyl chalcone is generally well tolerated in the amounts found in food and during short-term supplement use, but long-term safety data is scarce. One case of allergic skin rash was reported in a person who applied it topically, though that person had no known allergies beforehand.

The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know whether it's safe for the baby. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Hesperidin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hesperidin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 702 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet medications (Moderate risk of increased bleeding), blood pressure medications, sedating drugs, calcium channel blockers like verapamil or diltiazem, or celiprolol. These are the medication types with documented theoretical interactions documented in the data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Hesperidin methyl chalcone is generally well tolerated but has theoretical interactions with several common medications, most notably blood thinners and heart drugs — and the evidence is mostly from animal studies, not humans. The supplement isn't established as effective for obesity, high cholesterol, or fatty liver disease.

If you take any prescription medications, check them against the interaction search tool on this page, and talk with your own doctor or pharmacist before adding this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hesperidin Methyl Chalcone 500 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950002876
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302670
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hesperidin Methyl Chalcone 500 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
753950002876
IngredientAmount% DV
Hesperidin Methyl Chalcone500 mg--

Other ingredients: Cellulose, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor's Best Hesperidin Methyl Chalcone contains Hesperidin, a flavonoid derived from citrus fruits that many experts believe has synergistic activity with vitamin C. While Hesperidin in its original form is not very water soluble, Hesperidin Methyl Chalcone is highly water soluble for greater absorption in the gastrointestinal tract. The antioxidant activity of hesperidin helps neutralize free radicals, support blood vessels, circulatory healthy, and vascular integrity. Hesperidin also helps support vein and capillary strength.

Formulation

Helps support vein and capillary strength Helps support blood vessel, circulatory health and vascular integrity

Helps support veins & capillaries

Vegan

Non-GMO Gluten Free Soy Free

This product contains natural ingredients that may vary in color.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Doctor's Best Science-Based Nutrition

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 capsule once daily, with food, or as recommended by a nutritionally informed physician.

Precautions

Warning: Consult your physician if you are pregnant, nursing, or taking blood thinning medications, before using hesperidin.

Avoid using hesperidin two (2) weeks prior and after surgery.

Storage

Store in a cool dry place.

Seals/Symbols

Vegan

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hesperidin Methyl Chalcone 500 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hesperidin Methyl Chalcone 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hesperidin Methyl Chalcone 500 mg by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Hesperidin Methyl Chalcone

Interacts with
702 drugs
500 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Methyl Chalcone monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hesperidin Methyl Chalcone 500 mg by Doctor's Best Drug Interactions

Want to check YOUR meds against Hesperidin Methyl Chalcone 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
702Drugs
702 Moderate

Ingredients driving the most interactions

Hesperidin Methyl Chalcone 702

Individual Drug Interactions

The ingredients in Hesperidin Methyl Chalcone 500 mg interact with 702 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hesperidin Methyl Chalcone 500 mg interact with drugs. Each result below shows which ingredient is responsible. Hesperidin Methyl Chalcone

Each ingredient & the kinds of drugs it affects

For each ingredient in Hesperidin Methyl Chalcone 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hesperidin Methyl Chalcone7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin Methyl Chalcone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hesperidin Methyl Chalcone 500 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
Tustin
State
California
ZipCode
92780
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Hesperidin Methyl Chalcone 500 mg by Doctor's Best: Common Questions

Does Hesperidin Methyl Chalcone 500 mg by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Hesperidin Methyl Chalcone 500 mg has a known interaction with 702 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hesperidin Methyl Chalcone 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it during pregnancy and breastfeeding because there isn't enough information about whether it's safe for your baby. Talk with your doctor or pharmacist for personalized advice.
Does hesperidin methyl chalcone actually work for weight loss or cholesterol?
The evidence suggests it's likely ineffective for both obesity and high cholesterol. If you're looking to manage either of those, discuss proven options with your doctor.
What is hesperidin methyl chalcone, and where does it come from?
It's a bioflavonoid — a plant compound — derived from hesperidin, which occurs naturally in citrus fruits. This version (the methyl chalcone form) is a modified version used in supplements.
Are there any side effects I should know about?
It's generally well tolerated, but one person reported an allergic skin rash after topical application. Long-term safety data is limited, so if you experience any unusual symptoms, stop and talk with your pharmacist.
Can I take this with my blood pressure medication?
There's a theoretical concern that hesperidin might lower blood pressure further, so you'll want to check with your doctor or pharmacist before adding it. Don't start without clearing it first — they can review your specific medication and dosing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hesperidin Methyl Chalcone 500 mg label
Go deeper

The Full Monographs Behind Hesperidin Methyl Chalcone 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph →
Sources

Sources & How We Checked

Hesperidin Methyl Chalcone 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
  8. Cho, YA, Choi, DH, and Choi, JS. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. J Pharm Pharmacol. 2009;61(6):825-829. PubMed
  9. Piao, YJ and Choi, JS. Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. Arch Pharm Res. 2008;31(4):518-522. PubMed
  10. Andersen KE. Hesperidin methyl chalcone?-?a new cosmetic contact allergen. Contact Dermatitis. 2015;72(6):402-4. PubMed
  11. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93(1):73-80. PubMed
  12. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018;32(6):1073-1079. PubMed
  13. Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei A. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials PubMed
  14. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. PubMed

See these in context on the Hesperidin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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