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Dietary supplement

High Lignan Flax Oil 1000 mg Ingredients & Drug Interactions

by NOW

High Lignan Flax Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Lignan Flax Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Lignan Flax Oil 1000 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Flax seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Lignan Flax Oil 1000 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with High Lignan Flax Oil 1000 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Lignan Flax Oil 1000 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 3 active ingredients: polyunsaturated fat, monounsaturated fat, and organic flaxseed oil at 1000 mg per dose. Flaxseed oil is a source of alpha-linolenic acid (ALA), a plant-based omega-3 fatty acid.

The product also carries inactive ingredients — a natural antioxidant blend and organic flax particulate matter — to round out the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Flaxseed Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: omega-3 fatty acid and essential nutrient source.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Dry skin, Rheumatoid arthritis (RA), cholesterol health — and 1 related terms.
  • The closest evidence on file: Flaxseed Oil is rated "Possibly Ineffective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Flaxseed Oil is rated "Possibly Ineffective" for Rheumatoid arthritis (RA).
  • Also on file: Flaxseed Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Dry skin, Hypertension.

The evidence on flaxseed oil for the conditions we have data on is weak. It's rated possibly ineffective for high cholesterol (hyperlipidemia), obesity, rheumatoid arthritis (RA), and bipolar disorder.

That doesn't mean it won't help you personally, only that the clinical trials we have don't show consistent benefit for those uses.

The evidence, ingredient by ingredient Flaxseed Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Flaxseed oil is generally well tolerated when taken by mouth. A small number of people report mild side effects like changes in bowel habits, dry mouth, or indigestion at doses around 5 grams daily.

Rarely, severe allergic reactions such as anaphylaxis have occurred. Very high doses (30 grams per day and above) have been linked to loose stools and diarrhea.

Quality and dose vary between products, so check the label. There isn't enough reliable safety data overall, so talk with your doctor before starting.

Safety during breastfeeding is limited, so breastfeeding parents should use it only with medical advice.

Side effects, ingredient by ingredient Flaxseed Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Flaxseed Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — flaxseed oil may increase bleeding risk. Also confirm this is okay if you're on blood pressure medications; it could theoretically lower your pressure further.

If you take ezetimibe (Zetia), the two may interfere with each other's absorption.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

High Lignan Flax Oil may appeal to you if you're interested in flaxseed oil's omega-3 content, but the clinical evidence for its common uses is not strong. If you take blood thinners, blood pressure medications, or ezetimibe for cholesterol, you'll want to clear this with your doctor or pharmacist first — interactions are possible.

Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Lignan Flax Oil 1000 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739017802
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 245211
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Lignan Flax Oil 1000 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
UPC/BARCODE
733739017802
IngredientAmount% DV
Calories30 Calorie(s)--
Saturated Fat0.5 Gram(s)2%
Total Fat3 Gram(s)4%
Polyunsaturated Fat2 Gram(s)--
Monounsaturated Fat0.5 Gram(s)--
organic Flax seed Oil3 Gram(s)--

Other ingredients: organic Flax seed Oil, Softgel Capsule, organic Flax particulate matter, Natural Antioxidant Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 3 softgels daily with a meal.

Formula

Flax Oil is a natural reservoir for the omega-3 fatty acid, alpha-linolenic acid (ALA). ALA is considered an essential fatty acid, because the body cannot make it from other fats and must obtain it from the diet. Flax Oil has been shown to support cardiovascular health and to promote the maintenance of healthy skin. It also abounds in lignans, which are phenolic compounds that may contribute to ALA’s role in maintaining cardiovascular health.

Each serving may also have the following naturally occurring amounts of polyunsaturated fats and monounsaturated fats: Linolenic Acid (Omega-3) 55%; Linoleic Acid (Omega-6) 14%; Oleic Acid (Omega-9) 19%; Other (Saturated) 12%.

With essential omega-3's Made with organic flax oil

Triangle K (Kosher)

Contains gelatin

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Flax Oil is generally well tolerated, but may be associated with mild temporary gastro-intestinal disturbances.

Consult physician if pregnant/nursing, taking medication, or have a medical condition, including allergy to flaxseed.

Consult physician if pregnant/nursing, taking medication, or have a medical condition, including allergy to flaxseed.

Keep out of reach of children.

Natural mixed tocopherols from soy.

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Cardiovascular support

Non-GMO

Certified Organic by QAI

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients.

Storage

Store in a cool, dry place after opening.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

General Statements

Nutritional oils Family owned since 1968.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Lignan Flax Oil 1000 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Lignan Flax Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Lignan Flax Oil 1000 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Organic Flax seed Oil

Interacts with
293 drugs
3 Gram(s) per serving

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Organic Flax seed Oil monograph & interactions

Other (inactive) ingredients: Organic Flax seed Oil, Softgel Capsule, Organic Flax particulate matter, Natural Antioxidant Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Lignan Flax Oil 1000 mg by NOW Drug Interactions

Want to check YOUR meds against High Lignan Flax Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

organic Flax seed Oil 293

Individual Drug Interactions

The ingredients in High Lignan Flax Oil 1000 mg interact with 293 drugs. Click any drug to see the details.

1 of the 1 ingredient in High Lignan Flax Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. organic Flax seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in High Lignan Flax Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Flax seed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
organic Flax seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Lignan Flax Oil 1000 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

High Lignan Flax Oil 1000 mg by NOW: Common Questions

Does High Lignan Flax Oil 1000 mg by NOW interact with any medications?
Yes. Based on its ingredients, High Lignan Flax Oil 1000 mg has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Lignan Flax Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is flaxseed oil safe to take while pregnant?
Flaxseed oil is rated possibly safe during pregnancy, but there isn't a lot of reliable safety data. Talk with your doctor or pharmacist before taking it — they know your full pregnancy situation and can advise you personally.
Can I take this while breastfeeding?
Safety data during breastfeeding is limited. Use it only with medical advice from your doctor or pharmacist, who can weigh the risks and benefits for you and your baby.
Does flaxseed oil work for high cholesterol?
The evidence doesn't show it's effective for high cholesterol — it's rated possibly ineffective. That said, individual results vary, and your doctor can tell you whether it makes sense for your specific situation.
What side effects should I watch for?
Most people tolerate it well. A small number report mild effects like changes in bowel habits, dry mouth, or indigestion. At very high doses (30 grams daily or more), loose stools and diarrhea can occur. Rare severe allergic reactions have been reported.
Why does the product list say it might interact with 293 medications?
That count includes all the individual blood pressure drugs, blood thinners, and other medications affected by flaxseed oil's three main interaction types. You probably only take a few of those, so use the checker on this page to see which ones apply to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Lignan Flax Oil 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Lignan Flax Oil 1000 mg label
Go deeper

The Full Monographs Behind High Lignan Flax Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph →
Sources

Sources & How We Checked

High Lignan Flax Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Flaxseed Oil 21 references
  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed
  16. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
  17. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
  18. Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
  19. Jamilian M, Tabassi Z, Reiner Z, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020;123(7):792-799
  20. Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
  21. Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):

See these in context on the Flaxseed Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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