Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

High Potency Krill Oil Ingredients & Drug Interactions

by WholeHealth

High Potency Krill Oil label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency Krill Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Potency Krill Oil is a dietary supplement by WholeHealth with 6 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Krill Oil Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency Krill Oil by WholeHealth

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency Krill Oil by WholeHealth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency Krill Oil by WholeHealth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

This softgel contains five active ingredients centered on omega-3 fatty acids from krill. The two major omega-3 components are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are delivered via a krill oil blend that also includes phospholipids and total omega-3 fatty acids.

Astaxanthin, a carotenoid compound, rounds out the formula. The capsule itself is the only inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Dry eye via Krill Oil Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dry eye — rated "Possibly Effective" (Krill Oil) (Natural Medicines).

Krill oil is possibly effective for dry eye; the evidence for its use in aging skin, Alzheimer disease, cancer, high cholesterol, and cognitive function is insufficient to rate. Astaxanthin shows insufficient reliable evidence for age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome.

In short, the evidence backing this product's broader health claims remains limited in the data we hold.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated at doses up to 4 grams daily. The most common side effects are digestive — bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort.

Headache, tiredness, and dizziness have been reported rarely. These effects tend to be milder or less frequent with krill oil than with fish oil.

Avoid this product if you have a shellfish allergy and use caution if you have a bleeding disorder. Astaxanthin is generally well tolerated in studies, though long-term safety data are limited.

Common side effects include abdominal pain, diarrhea, and red-colored stools. The safety data for both ingredients during pregnancy and breastfeeding are insufficient; talk to your doctor before using this product if you are pregnant or nursing.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before taking it with blood thinners or antiplatelet drugs (moderate risk of increased bleeding) and diabetes medications (moderate risk of low blood sugar). Also confirm it won't interfere with any drugs processed through your liver's CYP3A4 or CYP2B6 pathways — your pharmacist can flag these quickly.

If you have a shellfish allergy or bleeding disorder, discuss this supplement with your doctor before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have dry eyes and no bleeding disorder or shellfish allergy, this supplement may be worth a try — though the broader health claims lack strong evidence. If you take blood thinners, diabetes medications, or drugs your liver processes heavily, check with your own doctor or pharmacist first; the interaction potential is real enough to warrant a conversation.

Expect digestive side effects in the first week or two, and know that long-term safety data on astaxanthin are still limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency Krill Oil, straight from the product label.

Brand WholeHealth
Barcode (UPC) 836485000064
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 248488
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency Krill Oil by WholeHealth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Soft Gel(s)
Maximum serving Sizes:
2 Soft Gel(s)
Servings per container
30
UPC/BARCODE
836485000064
IngredientAmount% DV
Calories from Fat10 Calorie(s)--
Eicosapentaenoic Acid150 mg--
Docosahexaenoic Acid90 mg--
Phospholipids420 mg--
Total Fat1 Gram(s)1%
Total Omega-3 Fatty Acids300 mg--
Total Calories11.5 Calorie(s)--
Krill Oil Blend1000 mg--
Astaxanthin1.5 mg--

Other ingredients: Softgel Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The trusted name in natural health products

Formulation

Wholehealth premium supplements

Does not contain: milk, eggs, tree nuts, peanuts, wheat, or soybeans.

Enzymotec that ensures superior freshness and potency.

Manufactured in the U.S.A. Lab assayed for purity. Formula is proposition 65 compliant.

Formula

Antarctic krill with asaxanthin

Contains: Shellfish (krill), and fish (anchovy, mackerel, sardine, herring, tuna or a combination thereof).

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take two softgels once daily with water, or as recommended by a health care practitioner.

Precautions

Consult your health care practitioners prior to use and inform your pharmacist of all dietary supplements you are taking.

Keep out of reach of children.

Do not use if outer seal is broken or missing.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Kreal and MSO are trademarks of enzymotec ltd. MSO is a special manufacturing technology by enzymotex that ensures superior freshness and potency.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Potency Krill Oil by WholeHealth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency Krill Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency Krill Oil by WholeHealth

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Soft Gel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phospholipids

420 mg per serving

Total Omega-3 Fatty Acids

300 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Total Calories

11.5 Calorie(s) per serving

Krill Oil Blend

Interacts with
208 drugs
1000 mg per serving Form: Astaxanthin, Euphausia superba Krill Oil extract, Fish Oil extract, Medium-Chain Triglycerides

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil Blend monograph & interactions

Astaxanthin

Interacts with
671 drugs
1.5 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Softgel Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency Krill Oil by WholeHealth Drug Interactions

Want to check YOUR meds against High Potency Krill Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Krill Oil Blend 208

Individual Drug Interactions

The ingredients in High Potency Krill Oil interact with 838 drugs. Click any drug to see the details.

2 of the 6 ingredients in High Potency Krill Oil interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Krill Oil Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency Krill Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Krill Oil Blend2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency Krill Oil, from the product label.

WholeHealth

See all WholeHealth products
Name
WholeHealth Products
City
Santa Rosa
State
CA
ZipCode
95407
Phone Number
1-866-381-7693
Web Address
www.WholeHealth.com
Pharmacist Counseling Corner

High Potency Krill Oil by WholeHealth: Common Questions

Does High Potency Krill Oil by WholeHealth interact with any medications?
Yes. Based on its ingredients, High Potency Krill Oil has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency Krill Oil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner?
Krill oil may increase bleeding risk when combined with blood thinners or antiplatelet drugs — that's a moderate concern. Talk to your doctor or pharmacist before adding it to your regimen; they can weigh the benefit against the risk for your specific situation.
What are the most common side effects?
Most people experience digestive upset — bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, or stomach discomfort. These tend to be milder with krill oil than with fish oil and often settle down after a few days.
Is it safe to take during pregnancy?
There isn't enough safety data on either krill oil or astaxanthin in pregnancy to say either way. Talk to your doctor before using it if you're pregnant — they can help you weigh whether the potential benefit outweighs the unknowns.
Does this actually help with dry eyes?
Krill oil is possibly effective for dry eye, which means there's some evidence supporting its use — but it's not definitive. You may find it helpful, though results vary from person to person.
What's astaxanthin doing in here?
Astaxanthin is a pigment from krill with antioxidant properties. However, the evidence that it helps with age-related cognitive decline, macular degeneration, or other conditions listed on the label is insufficient to rate, so its role in this formula is mainly complementary.
Are there any fillers or other junk in the capsules?
The softgel capsule itself is the only inactive ingredient listed — no extra fillers. What you're getting is the five active ingredients wrapped in the capsule material.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Potency Krill Oil is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency Krill Oil label
Go deeper

The Full Monographs Behind High Potency Krill Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

High Potency Krill Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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