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Dietary supplement

Hordenine 5 g Ingredients & Drug Interactions

by Absorb Health

Hordenine 5 g label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hordenine 5 g against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hordenine 5 g is a dietary supplement by Absorb Health with 1 active ingredient. Its ingredients are commonly taken for energy and stimulation, athletic and workout performance, weight loss/fat burning.Based on those ingredients, 329 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hordenine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hordenine 5 g by Absorb Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Hordenine 5 g by Absorb Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hordenine 5 g by Absorb Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Hordenine 5 g is a single-ingredient powder supplement. Hordenine is a compound structurally related to stimulants found in bitter orange; it's thought to work on the sympathetic nervous system in a way similar to those compounds.

There are no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Sports support and athletic performance.
  • We looked for evidence on: Athletic endurance, Exercise performance, Workout recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for hordenine in the data we have on file. The evidence supporting its health benefits isn't established here.

The evidence, ingredient by ingredient Hordenine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for hordenine is very limited, and the available evidence notes it acts as a stimulant. Because hordenine is structurally similar to other stimulants like those in bitter orange, it may theoretically cause stimulant-related side effects — including a fast heartbeat and high blood pressure — though these haven't been reported or studied in people.

No clinical trials have formally evaluated hordenine's safety in humans. The safety data advises against use during pregnancy and while breastfeeding because no safety studies exist for either.

Side effects, ingredient by ingredient Hordenine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hordenine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 329 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these categories: monoamine oxidase inhibitors (MAOIs) — the most serious concern — stimulant drugs like amphetamines and methylphenidate, and any medication broken down by the liver enzyme CYP2D6, including some antidepressants and pain relievers. Use the interaction checker on this page with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Hordenine is a stimulant-like supplement with very limited human safety data. It's not right for you if you take MAOIs, other stimulants, or certain other medications that are broken down by your liver.

Talk to your pharmacist before starting — especially if you have heart or blood pressure concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hordenine 5 g, straight from the product label.

Brand Absorb Health
Barcode (UPC) 790566991040
Net contents 5 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215778
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hordenine 5 g by Absorb Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mg
Maximum serving Sizes:
5 mg
Servings per container
5
UPC/BARCODE
790566991040
IngredientAmount% DV
Hordenine5 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Sports Support

Free of sugar, soy, dairy, yeast, gluten or additives

General Statements

US standard measuring spoons Spoon size (level) Miligrams 1/4 teaspoon 447 1/2 teaspoon 894 1 teaspoon 1789

Suggested/Recommended/Usage/Directions

Directions: As dietary supplement, take 5 mg daily

FDA Statement of Identity

Directions: As dietary supplement, take 5 mg daily

Storage

Keep dry, cool & dark

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hordenine 5 g by Absorb Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hordenine 5 g label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hordenine 5 g by Absorb Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 mg Dosage formPowder Servings per container5 Amounts shown are per serving.

Hordenine

Interacts with
329 drugs
5 mg per serving

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human eviden...

Hordenine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hordenine 5 g by Absorb Health Drug Interactions

Want to check YOUR meds against Hordenine 5 g?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
329Drugs
180 Moderate 149 Minor

Ingredients driving the most interactions

Hordenine 329

Individual Drug Interactions

The ingredients in Hordenine 5 g interact with 329 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hordenine 5 g interact with drugs. Each result below shows which ingredient is responsible. Hordenine

Each ingredient & the kinds of drugs it affects

For each ingredient in Hordenine 5 g with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hordenine3 drug types · 329 drugs

Monoamine Oxidase Inhibitors (Maois)

Hordenine is structurally similar to tyramine In vitro research shows that hordenine is a selective substrate for monoamine oxidase-B in the liver. Theoretically, concomitant use of hordenine with MAOIs might increase blood pressure, potentially leading to a hypertensive crisis.
Some MAOIs include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).

Likelihood Possible Evidence D
Stimulant Drugs

Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties. Theoretically, taking hordenine with drugs with stimulant properties might increase the risk of hypertension and other adverse cardiovascular effects.
Some of these drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro. Theoretically, hordenine might increase the levels of CYP2D6 substrates.
Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.

Likelihood Possible Evidence D
Hordenine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hordenine 5 g, from the product label.

Absorb Health

See all Absorb Health products
Name
Absorb Health
Street Address
4705 Southport-Supply Rd., 202
City
Southport
State
NC
ZipCode
28461
Pharmacist Counseling Corner

Hordenine 5 g by Absorb Health: Common Questions

Does Hordenine 5 g by Absorb Health interact with any medications?
Yes. Based on its ingredients, Hordenine 5 g has a known interaction with 329 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hordenine 5 g contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hordenine and what is it supposed to do?
Hordenine is a plant-derived compound that works on your sympathetic nervous system — the same system stimulant drugs target. It's structurally similar to stimulants found in bitter orange, but human research on what it actually does isn't established in the data we hold.
Can I take this if I'm on an antidepressant?
It depends on which one. If you take a monoamine oxidase inhibitor (MAOI) like phenelzine, you should not take hordenine — the combination could dangerously raise your blood pressure. Other antidepressants may be affected by hordenine's weak effect on liver enzymes. Check with your pharmacist about your specific medication.
Is this safe during pregnancy or while breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding because no safety studies exist for either. Talk to your doctor if you're thinking about hordenine while pregnant or nursing.
What side effects might hordenine cause?
No clinical studies have tested hordenine in humans, so we don't have real-world side effect data. But because it's structurally similar to other stimulants, it could theoretically cause a fast heartbeat and high blood pressure — though these haven't been reported in people.
Can I combine this with caffeine or energy drinks?
That's not a good idea. Hordenine is itself a stimulant, and combining it with caffeine or other stimulants could increase the risk of high blood pressure and heart problems. Check with your pharmacist first.
Does this product have any fillers or other inactive ingredients?
No — this is a pure hordenine powder with no inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hordenine 5 g label
Go deeper

The Full Monographs Behind Hordenine 5 g’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hordenine

Interacts with 329 drugs

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human evidence for these benefits is lacking. Its sa...

Read the full Hordenine monograph →
Sources

Sources & How We Checked

Hordenine 5 g's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hordenine 3 references
  1. Barwell CJ, Basma AN, Lafi MA, Leake LD. Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol 1989;41(6):421-3. PubMed
  2. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed
  3. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed

See these in context on the Hordenine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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