Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Hormone Advantage Ingredients & Drug Interactions

by Thorne

Hormone Advantage label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hormone Advantage against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hormone Advantage is a dietary supplement by Thorne with 3 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 980 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate Whole Fruit Extract, Sulforaphane Glucosinolate, Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hormone Advantage by Thorne

Ask about any prescription or over-the-counter medication and we check it for interactions with Hormone Advantage by Thorne — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hormone Advantage by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Hormone Advantage contains 3 active ingredients: pomegranate whole fruit extract, diindolylmethane, and sulforaphane glucosinolate. The product also includes two inactive ingredients — hypromellose and calcium laurate — which are capsule and binding materials.

Pomegranate extract is included for its potential effects on blood pressure and cholesterol. Diindolylmethane is a compound from cruciferous vegetables, and sulforaphane glucosinolate (a broccoli-derived compound) is the precursor to sulforaphane, an active plant compound.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Men's and women's hormone and liver health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Breast cancer, Liver disease, Mastalgia, Menopausal symptoms, Nonalcoholic fatty liver disease (NAFLD) — and 4 related terms.
  • The strongest evidence on file: Sulforaphane is rated "Possibly Effective" for Prostate cancer (Natural Medicines).
  • Also on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Prostate cancer, Nonalcoholic fatty liver disease (NAFLD), Menopausal symptoms.
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Breast cancer, Mastalgia.

Pomegranate shows possibly effective evidence for high blood pressure (hypertension), but the data suggests it is possibly ineffective for high cholesterol (hyperlipidemia) and blood sugar issues (diabetes). There's insufficient evidence to rate it for nonalcoholic fatty liver disease.

For the other two ingredients, the evidence we hold is not established: diindolylmethane and sulforaphane glucosinolate have insufficient reliable evidence for the conditions listed (prostate cancer, benign prostatic hyperplasia, various cancers, cervical dysplasia, and others). Sulforaphane is rated possibly effective for prostate cancer, but possibly ineffective for Helicobacter pylori infection.

The evidence, ingredient by ingredient Pomegranate Diindolylmethane Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pomegranate fruit and juice are generally well tolerated as food. The most common side effects from oral pomegranate are mild — diarrhea and gas — occurring in small numbers of people at typical doses, though higher extract doses (3,000 mg daily) caused diarrhea in about 10% of trial participants.

Concentrated pomegranate extracts and peel or leaf preparations have limited safety data, so use caution with them. Diindolylmethane is generally well tolerated in short-term studies, but long-term safety isn't well established.

Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting; a rare serious side effect (drug rash with eosinophilia and systemic symptoms, or DRESS) has been reported. Sulforaphane from food is considered safe, but concentrated supplements are less studied long-term.

Reported side effects include bowel discomfort, heartburn, stomach upset, vomiting, and headache. One clinical trial in young males with autism reported an average weight gain of 4 pounds over 18 weeks.

Rare cases of seizure have been reported, and insomnia and irritability occurred in clinical trials.

Side effects, ingredient by ingredient Pomegranate Diindolylmethane Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pomegranate, Diindolylmethane, Sulforaphane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 981 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Hormone Advantage, double-check your medications with your doctor or pharmacist, especially: blood pressure medications (antihypertensives) and ACE inhibitors — pomegranate may lower blood pressure further; blood thinners like warfarin — pomegranate may raise bleeding risk; cholesterol medications like rosuvastatin; estrogens or hormone replacement therapy — diindolylmethane may interfere; diuretics (water pills); and any drugs processed through your liver's CYP2D6, CYP2C9, CYP3A4, CYP1A2, or CYP2E1 pathways. Altogether, these interactions span 981 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is intended for people interested in hormone balance and may appeal to those exploring natural support for blood pressure or prostate health, though evidence is limited for most uses. If you take blood pressure medications, ACE inhibitors, blood thinners, cholesterol drugs, or any medication processed through liver enzyme systems, you'll need to check your specific medications with the tool below before starting.

Talk with your doctor or pharmacist about whether this product is right for you, especially if you're on hormone therapy, have a seizure history, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hormone Advantage, straight from the product label.

Brand Thorne
Barcode (UPC) 693749006916
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 298069
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hormone Advantage by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
693749006916
IngredientAmount% DV
Pomegranate Whole Fruit Extract100 mg--
Diindolylmethane150 mg--
Sulforaphane Glucosinolate25 mg--

Other ingredients: Hypromellose, Calcium Laurate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Men's health Women's health

DIM with pomegranate and broccoli extract

Formulation

Liver/Detox

Gluten free

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule one to two times daily or as recommended by your health-care practioner.

Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Storage

Store tightly sealed in a cool, dry place.

Seals/Symbols

Manufactured in the USA using US & imported ingredients

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

The extraction of glucosinolates from cruciferous seeds is protected by U.S. Patent No. 5,725,895. The use of this product is protected by U.S. Patent Nos. 5,968,505 and 5,968,567. TruBroc is a trademark of Brassica Protection Products LLC.

The extraction of glucosinolates from cruciferous seeds is protected by U.S. Patent No. 5,725,895. The use of this product is protected by U.S. Patent Nos. 5,968,505 and 5,968,567. Truebroc is a trademark of Brassica Protection Products LLC.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hormone Advantage by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hormone Advantage label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hormone Advantage by Thorne

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pomegranate Whole Fruit Extract

Interacts with
922 drugs
100 mg per serving

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate Whole Fruit Extract monograph & interactions

Diindolylmethane

Interacts with
269 drugs
150 mg per serving Form: Crystalline DIM

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Sulforaphane Glucosinolate

Interacts with
722 drugs
25 mg per serving Form: Broccoli seed extract

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effec...

Sulforaphane Glucosinolate monograph & interactions

Other (inactive) ingredients: Hypromellose, Calcium Laurate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hormone Advantage by Thorne Drug Interactions

Want to check YOUR meds against Hormone Advantage?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
980Drugs
936 Moderate 44 Minor

Ingredients driving the most interactions

Pomegranate Whole Fruit Extract 922
Sulforaphane Glucosinolate 722
Diindolylmethane 269

Individual Drug Interactions

The ingredients in Hormone Advantage interact with 980 drugs. Click any drug to see the details.

3 of the 3 ingredients in Hormone Advantage interact with drugs. Each result below shows which ingredient is responsible. Pomegranate Whole Fruit Extract Sulforaphane Glucosinolate Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in Hormone Advantage with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate Whole Fruit Extract9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate Whole Fruit Extract full monograph & interactions

Sulforaphane Glucosinolate3 drug types · 722 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP2E1 substrates.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Sulforaphane Glucosinolate full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hormone Advantage, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

Hormone Advantage by Thorne: Common Questions

Does Hormone Advantage by Thorne interact with any medications?
Yes. Based on its ingredients, Hormone Advantage has a known interaction with 980 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hormone Advantage contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Hormone Advantage if I'm pregnant or breastfeeding?
Pomegranate is rated possibly safe in pregnancy. Diindolylmethane is rated likely safe in pregnancy, but there isn't enough safety data while breastfeeding, so it's best avoided during nursing. Sulforaphane from food is considered likely safe, but concentrated supplements haven't been proven safe in pregnancy — stick to dietary amounts if you're pregnant — and there isn't enough information on supplement-level doses while breastfeeding. Talk with your doctor or pharmacist before starting this product if you're pregnant or nursing.
What are the most common side effects?
From pomegranate: diarrhea and gas. From diindolylmethane: diarrhea, gas, headache, nausea, rash, and vomiting. From sulforaphane: bowel discomfort, heartburn, stomach upset, vomiting, and headache. Most people tolerate these ingredients well, but GI upset is the most likely issue you might notice.
Will Hormone Advantage help with my high cholesterol?
Pomegranate is rated possibly ineffective for high cholesterol (hyperlipidemia) based on the evidence we hold. While some research suggests it might improve cholesterol in certain cases, the overall data doesn't support that it's an effective treatment for it.
Is there enough long-term safety data on these ingredients?
Pomegranate fruit and juice are well established as safe when used as food. However, concentrated pomegranate extracts have limited long-term safety data. Diindolylmethane is well tolerated short-term, but long-term safety isn't well established. Sulforaphane from food is considered safe, but concentrated supplements are less studied for long-term use.
Can sulforaphane cause seizures?
Seizures are rare, but cases have been reported in males with autism taking sulforaphane supplements. If you have a history of seizures or are on antiepileptic drugs, talk with your doctor or pharmacist before starting this product.
Will this product interfere with my hormone therapy?
Diindolylmethane may have mild estrogenic or antiestrogenic effects and could theoretically interfere with hormone replacement therapy. Check with your doctor or pharmacist before combining this product with any hormone therapy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hormone Advantage label
Go deeper

The Full Monographs Behind Hormone Advantage’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

Hormone Advantage's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pomegranate 27 references
  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
  5. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
  6. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
  8. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
  9. Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
  10. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
  11. Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
  12. Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
  13. Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
  14. Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
  15. Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed
  16. Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
  17. Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther PubMed
  18. Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J 2010;27:74-5. PubMed
  19. Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151. PubMed
  20. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study PubMed
  21. Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
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Diindolylmethane 14 references
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  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
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Sulforaphane 16 references
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  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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