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Dietary supplement

Huperzine-A 200 mcg Ingredients & Drug Interactions

by Double Wood Supplements

Huperzine-A 200 mcg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Huperzine-A 200 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Huperzine-A 200 mcg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, alzheimer's disease and dementia, age-related memory decline.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine-A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Huperzine-A 200 mcg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Huperzine-A 200 mcg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Huperzine-A 200 mcg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: huperzine-A, a naturally derived compound that works by slowing the breakdown of acetylcholine, a neurotransmitter involved in memory and thinking. Each tablet or pill delivers 200 micrograms.

The product also contains several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, and silicon dioxide — which are fillers and binders used to form and hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support mental performance memory focus and energy.
  • We looked for evidence on: Memory, Cognitive impairment, Alzheimer disease, Vascular dementia, Myasthenia gravis, Age-related cognitive decline — and 2 related terms.
  • The strongest evidence on file: Huperzine A is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Cognitive impairment, Vascular dementia, Memory, Myasthenia gravis.

Huperzine-A is possibly effective for Alzheimer disease based on the evidence we hold. For athletic performance, cognitive impairment, vascular dementia, depression, and memory, the evidence isn't established — there's insufficient reliable data to rate how well it works for those uses.

The evidence, ingredient by ingredient Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, huperzine-A is generally well tolerated, though it's a pharmacologically active compound that can cause real side effects and should be used with care and medical guidance. The most common side effects are dose-dependent and stem from its effects on acetylcholine: blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, and vomiting.

Some people have also reported decreased heart rate. There isn't enough safety data during pregnancy, so it's best avoided then.

Safety while breastfeeding is unknown, so avoid it as well.

Side effects, ingredient by ingredient Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Huperzine A.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check any cholinergic drugs (medications that boost acetylcholine effects) and anticholinergic drugs (medications that block acetylcholine effects) — both categories interact at Moderate severity. Use the search tool on this page to look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking at this for Alzheimer disease, the evidence suggests it might help — but talk with your doctor first. If you take any medications that affect acetylcholine (cholinergic or anticholinergic drugs), check them against our interaction tool before you start.

Because this is a pharmacologically active compound, run it by your pharmacist or doctor, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Huperzine-A 200 mcg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) X001LGPQZR
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255595
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Huperzine-A 200 mcg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
X001LGPQZR
IngredientAmount% DV
Huperzine-A200 mcg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Huperzine-A may support levels of the neurotransmitter Acetylcholine in the brain. By supporting levels of Acetylcholine, Huperzine A can help support energy, stamina, and optimal cognitive function.

200 mcg per tablet

Suggested/Recommended/Usage/Directions

Suggested Use: Take one tablet with or without food to support mental performance including memory, focus, motivation, and energy. Do not consume more than 4 tablets in one day and do not consume more than 1 tablet as a single time. Space out doses 3-4 hours.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Precautions

Warning: Consult your physician before using this product.

Do not take this product if you are pregnant, nursing, or taking any other medications.

Do not combine this product with acetylcholinesterase inhibitors. Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use Huperzine-A and operate any heavy machinery until you know how it affects you.

Keep out of reach of children.

Seals/Symbols

Proudly Made in USA

Formulation

Made with Non-GMO ingredients Gluten free

Promotes optimal cognitive function Supports energy and stamina

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Huperzine A Double Wood Supplements New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Huperzine-A 200 mcg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Huperzine-A 200 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Huperzine-A 200 mcg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Huperzine-A

Interacts with
219 drugs
200 mcg per serving

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine-A monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Huperzine-A 200 mcg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Huperzine-A 200 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Huperzine-A 219

Individual Drug Interactions

The ingredients in Huperzine-A 200 mcg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Huperzine-A 200 mcg interact with drugs. Each result below shows which ingredient is responsible. Huperzine-A

Each ingredient & the kinds of drugs it affects

For each ingredient in Huperzine-A 200 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine-A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine-A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Huperzine-A 200 mcg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Huperzine-A 200 mcg by Double Wood Supplements: Common Questions

Does Huperzine-A 200 mcg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Huperzine-A 200 mcg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Huperzine-A 200 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is huperzine-A and what does it do?
Huperzine-A is a naturally derived compound that slows the breakdown of acetylcholine, a brain chemical involved in memory and thinking. By preserving acetylcholine levels, it may support cognitive function.
Does huperzine-A actually work for memory?
The evidence we hold shows it's possibly effective for Alzheimer disease. For general memory improvement and other cognitive uses, the research data isn't established enough to rate how well it works.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. Safety while breastfeeding is unknown, so avoid it then too. Talk with your doctor or pharmacist if you have questions about your specific situation.
What side effects does huperzine-A cause?
When taken by mouth, it's generally well tolerated, but it can cause dose-dependent side effects related to acetylcholine: blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, vomiting, and in some cases decreased heart rate.
Is huperzine-A safe to use?
It's a pharmacologically active compound that can cause real side effects, so use it with care and medical guidance. Run it by your pharmacist or doctor before you start, especially if you take any medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Huperzine-A 200 mcg label
Go deeper

The Full Monographs Behind Huperzine-A 200 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Huperzine-A 200 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Huperzine A 13 references
  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

See these in context on the Huperzine A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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