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Dietary supplement

Nattokinase 4,000 FU 200 mg Ingredients & Drug Interactions

by Double Wood Supplements

Nattokinase 4,000 FU 200 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 4,000 FU 200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 4,000 FU 200 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 4,000 FU 200 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 4,000 FU 200 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 4,000 FU 200 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase, an enzyme derived from natto (a fermented soy food). Each capsule delivers 4,000 fibrin units (FU) of nattokinase in a 200 mg dose.

The remaining ingredients—hypromellose, rice flour, and microcrystalline cellulose—are inactive fillers and capsule material that help deliver the active ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health support.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence for nattokinase isn't established in our data for the conditions we checked. We hold insufficient reliable evidence to rate its use for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome.

That doesn't mean it doesn't work—just that the research we have access to doesn't yet support a clear effectiveness claim for these uses.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effect means caution if you have a bleeding disorder or take blood thinners. Rare cases of bleeding—including serious bleeding into the brain—have been reported, especially when combined with aspirin or other anticoagulants.

The safety data advises against using nattokinase during pregnancy, and there isn't enough information to know whether it's safe while breastfeeding, so it's best avoided in both situations. People with a known sensitivity to natto (the fermented soy food nattokinase comes from) should also avoid it, since hypersensitivity reactions, including anaphylaxis, have been reported.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you're on blood thinners or antiplatelet drugs (such as warfarin, apixaban, clopidogrel, or aspirin)—Moderate risk of increased bleeding. Also check if you take blood pressure medications, since nattokinase may lower blood pressure further.

Altogether, these interactions span 287 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may appeal to people interested in cardiovascular support, but the documented blood-thinning effect means you need to be cautious if you take any blood thinners or blood pressure medications. Talk with your pharmacist before starting this product—especially if you're on aspirin, warfarin, or other anticoagulants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 4,000 FU 200 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 850033272239
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 315687
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 4,000 FU 200 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
850033272239
IngredientAmount% DV
Nattokinase200 mg--

Other ingredients: Hypromellose, Rice Flour, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product Info: Nattokinase is an enzyme that comes from a Japanese food called natto (boiled soybeans that have been fermented). The enzyme is activated following ingestion to provide certain health benefits.

Nattokinase 4000 FU 200 mg per serving Max Activity (FU) Enzyme

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take 1 serving per day, with or without food.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Proudly Manufactured in the USA

Formulation

Made with Non-GMO Ingredients Gluten Free

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Soy

Warning: Consult your physician before use.

Do not use Nattokinase if you are pregnant, nursing, or under 18 years of age.

Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use Nattokinase and operate heavy machinery until you know how it affects you.

Keep out of reach of children.

Do not exceed 4 capsules per day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 4,000 FU 200 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 4,000 FU 200 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 4,000 FU 200 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
200 mg per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 4,000 FU 200 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Nattokinase 4,000 FU 200 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 4,000 FU 200 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 4,000 FU 200 mg interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 4,000 FU 200 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 4,000 FU 200 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Nattokinase 4,000 FU 200 mg by Double Wood Supplements: Common Questions

Does Nattokinase 4,000 FU 200 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Nattokinase 4,000 FU 200 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 4,000 FU 200 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take nattokinase if I'm on aspirin?
No—there's documented risk here. A case report shows someone taking nattokinase alongside low-dose aspirin developed serious bleeding in the brain. Talk with your doctor or pharmacist before combining them.
Is nattokinase safe during pregnancy or breastfeeding?
No. The safety data advises against it during pregnancy. There also isn't enough information to know whether it's safe while breastfeeding, so it's best avoided in both situations. Speak with your OB or midwife if you're interested.
What is nattokinase, and where does it come from?
Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It's known for its blood-thinning properties.
Can nattokinase cause allergic reactions?
Yes, people with a sensitivity to natto can have hypersensitivity reactions, ranging from throat and larynx swelling to anaphylaxis (a severe allergic emergency). Symptoms typically show up within 2 hours of taking it.
Does nattokinase actually work for heart health?
We don't have enough reliable evidence in our data to say whether nattokinase works for cardiovascular disease, angina, atherosclerosis, or chronic fatigue. The research backing its use for these conditions isn't yet established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattokinase 4,000 FU 200 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 4,000 FU 200 mg label
Go deeper

The Full Monographs Behind Nattokinase 4,000 FU 200 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 4,000 FU 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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