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Dietary supplement

Cissus Extract 1,000 mg Ingredients & Drug Interactions

by Double Wood Supplements

Cissus Extract 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Extract 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Extract 1,000 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Extract 1,000 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Extract 1,000 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus Extract 1,000 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus quadrangularis extract at 1,000 mg per capsule. It also includes inactive ingredients—hypromellose, cellulose, and rice flour—that serve as the capsule material and filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: bone and joint health support.
  • We looked for evidence on: Fractures, Joint pain, Osteopenia, Osteoporosis, Rheumatoid arthritis (RA), Bone density — and 2 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain, Rheumatoid arthritis (RA).

Cissus quadrangularis extract is possibly effective for obesity based on the evidence we have. For high cholesterol (hyperlipidemia), bone loss (osteopenia), cancer, and epilepsy, the evidence is insufficient to rate it—we don't have enough reliable data to say whether it works for those uses.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, but long-term safety hasn't been well studied. In clinical trials, some people reported headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth—but the rates of these side effects were similar to or lower than placebo, so they're not a major concern.

Not enough safety data exists to use this supplement during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drug—insulin, metformin, sulfonylureas, or others—verify your specific medications on this page before starting. This ingredient may increase the risk of low blood sugar when combined with diabetes medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus quadrangularis extract may be worth considering if you're interested in weight management and have looked into the modest evidence. If you take any diabetes medication, check your exact drugs with the interaction tool before you start.

Long-term safety data is limited, so talk with your doctor or pharmacist about whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Extract 1,000 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) X0013QZZCT
Net contents 150 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241729
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Extract 1,000 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
75
UPC/BARCODE
X0013QZZCT
IngredientAmount% DV
Cissus quadrangularis extract1000 mg--

Other ingredients: Hypromellose, Cellulose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cissus Quadrangularis Extract is a natural supplement derived from the Cissus Quadrangularis root. When taken as a supplement it has been shown to support bone and joint health.

Cissus Extract 1000 mg per serving Cissus quadrangularis

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for bone and joint health, take 2 capsules per day.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken or damaged.

Warning: Consult your physician if before taking this product. Do not consume more than 4 capsules per day..

Do not take this product if you are pregnant, nursing, or are taking any other medications.

Discontinue use and consult your doctor immediately immediately if any adverse reactions occur.

Do not take Cissus Quadrangularis Extract and operate any heavy machinery until you know how it affects you.

Keep out of reach of children.

Seals/Symbols

Proudly made in USA

Formulation

Made with Non-GMO ingredients Gluten Free

Promotes bone and joint health Promotes healthy cortisol levels

Tested for Purity

General Statements

Cissus Quadrangula Doublewood Supplements New

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Extract 1,000 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Extract 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Extract 1,000 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container75 Amounts shown are per serving.

Cissus quadrangularis extract

Interacts with
86 drugs
1000 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Cellulose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Extract 1,000 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Cissus Extract 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis extract 86

Individual Drug Interactions

The ingredients in Cissus Extract 1,000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Extract 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Extract 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Extract 1,000 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Cissus Extract 1,000 mg by Double Wood Supplements: Common Questions

Does Cissus Extract 1,000 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Cissus Extract 1,000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Extract 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take blood sugar medication?
Not without checking first. Cissus quadrangularis extract may theoretically increase the risk of low blood sugar when combined with antidiabetes drugs. Use the interaction checker on this page with your exact medications, then talk with your doctor or pharmacist before you start.
Is it safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. If you're thinking about taking it regularly, discuss that with your doctor or pharmacist.
Can I take this while pregnant or breastfeeding?
No—not enough safety data exists for either. The safety data advises against it. Talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or breastfeeding.
What side effects might I experience?
Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported, but the rates in trials were similar to or lower than placebo, so they're uncommon.
Does this actually help with weight management?
Cissus quadrangularis extract is rated possibly effective for obesity. Small clinical studies suggest it might help lower fasting blood sugar in people with overweight or obesity, but the evidence is modest.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Extract 1,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Extract 1,000 mg label
Go deeper

The Full Monographs Behind Cissus Extract 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Extract 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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