Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Hype Fruit Punch Ingredients & Drug Interactions

by Blackstone Labs

Hype Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hype Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hype Fruit Punch is a dietary supplement by Blackstone Labs with 5 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hype Fruit Punch by Blackstone Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Hype Fruit Punch by Blackstone Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hype Fruit Punch by Blackstone Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Hype Fruit Punch is a 5-ingredient powder. The active ingredients are Glycerol Monostearate, L-Norvaline, Agmatine Sulfate, Citrulline Malate, and Icariin.

Glycerol is included for its potential role in athletic performance and constipation. Agmatine and Citrulline Malate are amino acid compounds often used in athletic and workout formulas.

Icariin is a plant compound. The powder also contains inactive ingredients (flavors and silicon dioxide) used as excipients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: skin-splitting pumps and muscle cell expansion.
  • We looked for evidence on: Muscle strength, Athletic performance, Vascularity, Muscle hypertrophy, Exercise performance.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.

The evidence we hold is limited. Glycerol Monostearate is likely effective for constipation and possibly effective for athletic performance, but possibly ineffective for meningitis, prematurity, and stroke.

For L-Norvaline, Agmatine Sulfate, Citrulline Malate, and Icariin, the evidence we hold on their intended uses in this product is not established — no effectiveness ratings are on file for them in the data we have.

The evidence, ingredient by ingredient Glycerol Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycerol is generally well tolerated at normal amounts, but large doses can cause stomach upset and may lead to dehydration. Common side effects when taken orally include bloating, diarrhea, nausea, vomiting, dizziness, and headache.

Agmatine sulfate appears well tolerated in the short term, though long-term safety in humans isn't well studied. In small clinical trials, some people reported diarrhea, indigestion, and nausea — usually mild to moderate and resolving when they stopped.

Agmatine is not recommended in pregnancy or while breastfeeding due to insufficient safety data. We hold no adverse-effect data on L-Norvaline, Citrulline Malate, or Icariin.

Side effects, ingredient by ingredient Glycerol Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Hype Fruit Punch, double-check with your pharmacist or doctor if you're on blood pressure–lowering drugs (antihypertensives) or diabetes medications. Agmatine may theoretically deepen drops in blood pressure or blood sugar when combined with these.

We could not check L-Norvaline, Citrulline Malate, and Icariin against your medications, so mentioning those ingredients to your pharmacist is wise too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Hype Fruit Punch is aimed at athletes and workout enthusiasts, but if you take blood pressure medication or diabetes medication, you'll want to check with your doctor or pharmacist first — agmatine in this product may theoretically lower your blood pressure further or increase low blood sugar risk. If you're pregnant or breastfeeding, talk to your healthcare provider about whether this product is right for you, particularly because of the agmatine content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hype Fruit Punch, straight from the product label.

Brand Blackstone Labs
Barcode (UPC) 728028214611
Net contents 5.07 Oz(s); 150 Gram(s)
Market status On market
Date entered into DSLD Jul 24, 2019
DSLD ID 204977
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hype Fruit Punch by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
30
UPC/BARCODE
728028214611
IngredientAmount% DV
Glycerol Monostearate1 Gram(s)--
L-Norvaline100 mg--
Agmatine Sulfate750 mg--
Citrulline Malate2 Gram(s)--
Icariin150 mg--

Other ingredients: Natural & Artificial flavors, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Skin-splitting pumps Increases vascularity Muscle cell expansion

Nitric Oxide booster 30 servings Naturally & artificially flavored

Suggested/Recommended/Usage/Directions

Directions As a dietary supplement, take (1) scoop with 6-8 oz of water once per day, twenty (20) minutes before a workout. Do not exceed two scoops daily.

Precautions

Do not exceed two scoops daily.

Warning This product is intended to be consumed by healthy adults 18 years of age or older.

This product should only be used under medical or dietetic supervision. This product is not intended as a sole source of nutrition and should be consumed in conjunction with an appropriate physical training or exercise program.

This product is not suitable for children under 18 years of age or pregnant or nursing women. Keep out of reach of children.

This product is not suitable for children under 18 years of age or pregnant or nursing women.

Allergen Warning: Manufactured on shared equipment that also processes eggs, wheat, & Soy (Lecithin).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hype Fruit Punch by Blackstone Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hype Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hype Fruit Punch by Blackstone Labs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycerol Monostearate

No known
interactions
1 Gram(s) per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerol Monostearate monograph & interactions

L-Norvaline

100 mg per serving

Agmatine Sulfate

Interacts with
258 drugs
750 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Citrulline Malate

2 Gram(s) per serving

Icariin

150 mg per serving Form: Horny Goat Weed (leaf) extract

Other (inactive) ingredients: Natural & Artificial flavors, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hype Fruit Punch by Blackstone Labs Drug Interactions

Want to check YOUR meds against Hype Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Hype Fruit Punch interact with 258 drugs. Click any drug to see the details.

1 of the 5 ingredients in Hype Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Hype Fruit Punch with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hype Fruit Punch, from the product label.

Blackstone Labs

See all Blackstone Labs products
Name
Blackstone Labs
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-877-454-6861
Web Address
www.BlackStoneLabs.com
Pharmacist Counseling Corner

Hype Fruit Punch by Blackstone Labs: Common Questions

Does Hype Fruit Punch by Blackstone Labs interact with any medications?
Yes. Based on its ingredients, Hype Fruit Punch has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hype Fruit Punch contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine sulfate, and what is it doing in this product?
Agmatine is an amino acid compound often added to workout formulas. In this product, it's one of the active ingredients. Animal research suggests it may have effects on blood pressure and blood sugar, though evidence for its effects in people is still developing.
Can I take Hype Fruit Punch if I'm on blood pressure medication?
You'll need to check with your doctor or pharmacist first. Agmatine in this product may theoretically increase the risk of your blood pressure dropping too low when combined with blood pressure medications. Your healthcare provider can look at your specific drug and decide if it's safe for you.
What are the most common side effects of this product?
From the glycerol and agmatine content, the most common reported side effects are digestive: bloating, diarrhea, nausea, and indigestion. Some people also report headache and dizziness. These are usually mild and may resolve with continued use or by stopping the product.
Is this safe to use during pregnancy?
Agmatine sulfate in this product is not recommended in pregnancy because there isn't enough safety data. Talk to your doctor or pharmacist before taking Hype Fruit Punch if you're pregnant or planning to become pregnant.
Is this safe while breastfeeding?
Agmatine sulfate is not recommended while breastfeeding due to insufficient safety data. Check with your doctor or pharmacist before taking this product if you're nursing.
Does this product contain any fillers?
Yes — the inactive ingredients include silicon dioxide and natural & artificial flavors for taste and texture. These are excipients used in the powder formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hype Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hype Fruit Punch label
Go deeper

The Full Monographs Behind Hype Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Hype Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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