Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

I3C Indole 3-Carbinol 200 Ingredients & Drug Interactions

by LifeLink

I3C Indole 3-Carbinol 200 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking I3C Indole 3-Carbinol 200 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

I3C Indole 3-Carbinol 200 is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for estrogen and hormone balance support, breast and cervical health, prostate health.Based on those ingredients, 294 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indole-3-Carbinol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against I3C Indole 3-Carbinol 200 by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with I3C Indole 3-Carbinol 200 by LifeLink — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of I3C Indole 3-Carbinol 200 by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: indole-3-carbinol, a naturally occurring compound found in cruciferous vegetables like broccoli and cabbage. The product also includes inactive ingredients—maltodextrin, silicon dioxide, and magnesium stearate—which serve as filler, anti-caking agent, and flow aid in the capsule.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: hormonal cancer prevention support.
  • We looked for evidence on: Breast cancer, Cervical dysplasia, Colorectal cancer, Ovarian cancer, Recurrent respiratory papillomatosis, Prostate cancer — and 2 related terms.
  • The closest evidence on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Breast cancer (Natural Medicines).
  • Also on file: Indole-3-carbinol is rated "Insufficient Reliable Evidence To Rate" for Colorectal cancer, Cervical dysplasia, Ovarian cancer, Recurrent respiratory papillomatosis.

The evidence we hold does not establish reliable benefit for any of the conditions this product is marketed for. Indole-3-carbinol has been studied for breast cancer, ovarian cancer, cervical dysplasia, liver disease, colorectal cancer, and fibromyalgia, but in each case the evidence is insufficient to make a confident claim.

That doesn't mean it's ineffective—it means the data so far isn't robust enough for us to say either way.

The evidence, ingredient by ingredient Indole-3-carbinol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Indole-3-carbinol appears generally well tolerated at typical doses, though some people report diarrhea, nausea, dizziness, unsteadiness, rash, and tremor. At higher doses—particularly 400 mg twice daily—unsteadiness and tremor have occurred; these resolved when the dose was reduced.

Because supplement doses are less studied than food amounts, caution is warranted. Do not use this product during breastfeeding; safety data are not available.

Pregnancy safety data are also not on file, so talk with your doctor or pharmacist about whether it's appropriate for you.

Side effects, ingredient by ingredient Indole-3-carbinol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Indole-3-carbinol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 294 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your own doctor or pharmacist before taking this if you're on blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin, etc.), estrogen-based medications like birth control or hormone therapy, or any drug metabolized by the liver enzyme CYP1A2—including certain antidepressants and anticonvulsants. Indole-3-carbinol may reduce the effectiveness of estrogens and increase your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on estrogen therapy, blood thinners, or certain other medications, you'll want to check this one carefully with your doctor or pharmacist before adding it. The evidence for its intended benefits isn't yet established.

Because concentrated supplement doses are less studied than the compound in food, proceed cautiously.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about I3C Indole 3-Carbinol 200, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793300501
Net contents 60 Capsule(s); 200 mg
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 11766
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for I3C Indole 3-Carbinol 200 by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
639793300501
IngredientAmount% DV
Indole-3-Carbinol200 mg--

Other ingredients: Maltodextrin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: One capsule daily, or as directed by your qualified healthcare provider.

General Statements

Indole-3-carbinol (I3C) inhibits hormonal pathways involved in the development of cancers such as breast, cervical, colon, ovarian, and prostate cancers, and laryngeal papillomas. I3C is used as a preventative - it cannot inhibit tumors once they have started. When a precancerous condition is detected, an I3C supplement may prevent progression to cancer or even bring about a remission. A complete remission of Cervical Dysplasia is obtained in about 50% of cases when I3C is taken orally at 200-400 mg/day for 12 weeks.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

I3C Indole 3-Carbinol 200 by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

I3C Indole 3-Carbinol 200 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in I3C Indole 3-Carbinol 200 by LifeLink

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Indole-3-Carbinol

Interacts with
294 drugs
200 mg per serving

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...

Indole-3-Carbinol monograph & interactions

Other (inactive) ingredients: Maltodextrin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

I3C Indole 3-Carbinol 200 by LifeLink Drug Interactions

Want to check YOUR meds against I3C Indole 3-Carbinol 200?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
294Drugs
294 Moderate

Ingredients driving the most interactions

Indole-3-Carbinol 294

Individual Drug Interactions

The ingredients in I3C Indole 3-Carbinol 200 interact with 294 drugs. Click any drug to see the details.

1 of the 1 ingredient in I3C Indole 3-Carbinol 200 interact with drugs. Each result below shows which ingredient is responsible. Indole-3-Carbinol

Each ingredient & the kinds of drugs it affects

For each ingredient in I3C Indole 3-Carbinol 200 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for I3C Indole 3-Carbinol 200, from the product label.

LifeLink

See all LifeLink products
Name
LifeLink
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

I3C Indole 3-Carbinol 200 by LifeLink: Common Questions

Does I3C Indole 3-Carbinol 200 by LifeLink interact with any medications?
Yes. Based on its ingredients, I3C Indole 3-Carbinol 200 has a known interaction with 294 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
I3C Indole 3-Carbinol 200 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is indole-3-carbinol and where does it come from?
Indole-3-carbinol is a naturally occurring compound found in cruciferous vegetables like broccoli, cabbage, and kale. This supplement is a concentrated extract of that compound in capsule form.
Can I take this if I'm on birth control?
Not without checking first. Indole-3-carbinol may interfere with how estrogen in birth control works, potentially reducing its effectiveness. Talk with your doctor or pharmacist before adding this supplement.
What side effects should I watch for?
The most common are diarrhea and nausea. At higher doses, some people experience dizziness, unsteadiness, tremor, and rash. If you develop unsteadiness or imbalance, contact your doctor—these effects have resolved when the dose was lowered.
Is there good evidence this works for cancer or other conditions?
The evidence we hold is insufficient to rate it as effective for breast cancer, ovarian cancer, cervical dysplasia, colorectal cancer, liver disease, or fibromyalgia. That means more research is needed before we can say whether it helps.
Is this safe to use while pregnant or breastfeeding?
Pregnancy safety data are not on file for this supplement. Breastfeeding is not recommended because we don't have enough safety information. Talk with your doctor or pharmacist about whether it's right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if I3C Indole 3-Carbinol 200 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

I3C Indole 3-Carbinol 200 label
Go deeper

The Full Monographs Behind I3C Indole 3-Carbinol 200’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph →
Sources

Sources & How We Checked

I3C Indole 3-Carbinol 200's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Indole-3-carbinol 9 references
  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
  3. He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
  4. Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
  5. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  6. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
  7. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
  8. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  9. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

See these in context on the Indole-3-carbinol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team