No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Ilex Aquifolium Ingredients & Drug Interactions

by UNDA Gemmo

Ilex Aquifolium label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ilex Aquifolium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Ilex Aquifolium is a dietary supplement by UNDA Gemmo with 1 active ingredient. Its ingredients are commonly taken for fever, cough and chest congestion, joint pain (traditional use).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Ilex Aquifolium by UNDA Gemmo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: English Holly young shoot extract. Holly has been used traditionally, though safety data on leaf preparations is limited.

The product also contains glycerin, ethanol, and purified water as inactive ingredients to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Holly product and its label doesn't state a use — see Holly's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have established evidence on file for how well English Holly works for any condition. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports it.

The evidence, ingredient by ingredient Holly

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

English Holly leaf can cause stomach upset, including diarrhea, nausea, and vomiting. The leaf spines themselves may scratch or puncture skin or the inside of your mouth.

The berries are toxic — even a small number can cause serious harm, and ingestion of 20–30 berries can be fatal. There is no safety data to support use during pregnancy or while breastfeeding, so those aren't recommended.

Side effects, ingredient by ingredient Holly

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredient we could check. Still, run your medications through the tool on this page before you start, and let your doctor or pharmacist know you're taking it.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This product is from the young shoots of English Holly, a plant with limited safety data on leaf preparations. If you're pregnant, breastfeeding, or have a sensitive stomach, this one's not for you.

Talk with your doctor or pharmacist before adding it to your routine, especially if you're not sure what you're taking it for.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ilex Aquifolium, straight from the product label.

Brand UNDA Gemmo
Barcode (UPC) 88319630980
Net contents 4.2 Fluid Ounce(s); 125 mL
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241013
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ilex Aquifolium by UNDA Gemmo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.25 mL
Maximum serving Sizes:
1.25 mL
Servings per container
100
UPC/BARCODE
88319630980
IngredientAmount% DV
English Holly young shoot extract1.25 mL--

Other ingredients: Glycerin, Ethanol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Adults and children (over 12 years): Take 50 drops (1.25 ml) three times daily in a small amount of water or as recommended by your healthcare practitioner.

Precautions

Risk Information: If you are pregnant or breastfeeding, do not use, unless directed by your healthcare practitioner. Consult your healthcare practitioner prior to use if you are taking any medication or have any health condition.

Formula

Surculi recentes young shoot

FDA Statement of Identity

Dietary Supplement

General Statements

Seroyal UNDA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ilex Aquifolium by UNDA Gemmo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ilex Aquifolium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ilex Aquifolium by UNDA Gemmo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.25 mL Dosage formLiquid Servings per container100 Amounts shown are per serving.

English Holly young shoot extract

No known
interactions
1.25 mL per serving

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable h...

English Holly young shoot extract monograph & interactions

Other (inactive) ingredients: Glycerin, Ethanol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ilex Aquifolium by UNDA Gemmo Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Ilex Aquifolium. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Ilex Aquifolium, from the product label.

UNDA Gemmo

See all UNDA Gemmo products
Name
Seroyal USA
City
Pittsburg
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Pharmacist Counseling Corner

Ilex Aquifolium by UNDA Gemmo: Common Questions

Does Ilex Aquifolium by UNDA Gemmo interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Ilex Aquifolium. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Ilex Aquifolium contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is English Holly safe during pregnancy?
No — there's no safety data on Holly leaf during pregnancy, so it's not recommended. Talk with your doctor or pharmacist if you're pregnant and considering this product.
Can I take this while breastfeeding?
No — there's no safety data during breastfeeding, so it's advised against. Check with your doctor or pharmacist if you're nursing and thinking about using it.
What side effects might I notice?
Holly leaf can cause stomach irritation, diarrhea, nausea, and vomiting. The leaf spines can also scratch your mouth or throat. If you have a sensitive stomach, be extra careful.
Is this product safe for children?
The facts note that holly berries are particularly toxic to small children — even 2 berries can cause vomiting and diarrhea. This product is a leaf extract, not berries, but given the safety concerns with the plant itself, check with your pediatrician before giving it to a child.
What is English Holly leaf used for?
We don't have evidence on file for what Holly leaf is proven to do. If you're considering it for a specific reason, ask your doctor or pharmacist whether the evidence supports that use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ilex Aquifolium is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ilex Aquifolium label
Go deeper

The Full Monographs Behind Ilex Aquifolium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holly

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable human evidence supporting any health bene...

Read the full Holly monograph →
Sources

Sources & How We Checked

Ilex Aquifolium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Holly 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Holly monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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