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Dietary supplement

Phyto-Gen Spm-gen Ingredients & Drug Interactions

by Genestra Brands

Phyto-Gen Spm-gen label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phyto-Gen Spm-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phyto-Gen Spm-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset and bloating, urinary tract support.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Juniper (Juniperus communis) young shoot extract, Silver Linden (Tilia tomentosa) bud extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phyto-Gen Spm-gen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Phyto-Gen Spm-gen by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phyto-Gen Spm-gen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Phyto-Gen Spm-gen contains three active herbal extracts: juniper (Juniperus communis) young shoot extract, silver linden (Tilia tomentosa) bud extract, and English holly (Ilex aquifolium) young shoot extract. The liquid formula also includes water, ethanol, and glycerin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence base for these ingredients isn't established in our data. Juniper has been studied for gastroesophageal reflux disease (GERD), rheumatoid arthritis, urinary tract infections, wound healing, kidney stones, and bronchitis, but all carry insufficient reliable evidence to rate it.

We hold no effectiveness ratings for linden or English holly in this product.

The evidence, ingredient by ingredient Juniper Linden Holly

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Juniper is generally well tolerated at food doses, but medicinal amounts may irritate your kidneys and shouldn't be used long-term. Short-term use in low doses appears generally well tolerated, though allergies and skin irritation have been reported, especially with repeated exposure or concurrent sun exposure.

Linden is generally well tolerated as a tea, but human safety data are limited; one case report documented an allergic reaction to linden pollen in tea and contact skin irritation from a linden-containing shampoo. English holly leaf can cause stomach irritation, diarrhea, nausea, and vomiting — the spines may injure your mouth or digestive tract — and the berries are toxic; even a small number (2–5 berries) can cause vomiting and diarrhea in children.

Juniper is unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data. Linden safety isn't well studied in pregnancy or lactation.

English holly has no safety data and should be avoided during pregnancy and breastfeeding. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Juniper Linden Holly

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Linden, Juniper.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes medication, a diuretic drug, or lithium, you'll want to review this product with your doctor or pharmacist first — juniper and linden may affect how these work or how your body handles them. We have no interaction data for English holly, so we couldn't check what it might affect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a combination of three herbal extracts with limited evidence for effectiveness and several documented interactions with common medications — especially antidiabetes drugs, diuretics, and lithium. It's not suitable for pregnancy or breastfeeding.

If you take any prescription medications or are pregnant or nursing, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phyto-Gen Spm-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196121519
Net contents 0.5 Fluid Ounce(s); 15 mL
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264504
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phyto-Gen Spm-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
883196121519
IngredientAmount% DV
Juniper (Juniperus communis) young shoot extract0.09 mL--
Silver Linden (Tilia tomentosa) bud extract0.09 mL--
English Holly (Ilex aquifolium) young shoot extract0.09 mL--

Other ingredients: Water, Purified, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 10 drops once daily or as recommended by your health professional. Invert bottle to 45 degrees and shake lightly allowing drops to fall directly into mouth or in 1/4 oz of water.

Precautions

For warnings and additional information, see outer box.

Keep out of the reach of children.

Use only if safety seal is intact.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Storage

Store in a cool, dry place.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our quality excellence

FDA Statement of Identity

Dietary Supplement

Formula

Juniper Silver Linden English Holly

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phyto-Gen Spm-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phyto-Gen Spm-gen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phyto-Gen Spm-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Juniper (Juniperus communis) young shoot extract

Interacts with
162 drugs
0.09 mL per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper (Juniperus communis) young shoot extract monograph & interactions

Silver Linden (Tilia tomentosa) bud extract

Interacts with
1 drug
0.09 mL per serving

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evi...

Silver Linden (Tilia tomentosa) bud extract monograph & interactions

English Holly (Ilex aquifolium) young shoot extract

No known
interactions
0.09 mL per serving

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable h...

English Holly (Ilex aquifolium) young shoot extract monograph & interactions

Other (inactive) ingredients: Water, Purified, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phyto-Gen Spm-gen by Genestra Brands Drug Interactions

Want to check YOUR meds against Phyto-Gen Spm-gen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
87 Moderate 75 Minor

Ingredients driving the most interactions

Juniper (Juniperus communis) young shoot extract 162
Silver Linden (Tilia tomentosa) bud extract 1

Individual Drug Interactions

The ingredients in Phyto-Gen Spm-gen interact with 162 drugs. Click any drug to see the details.

2 of the 3 ingredients in Phyto-Gen Spm-gen interact with drugs. Each result below shows which ingredient is responsible. Juniper (Juniperus communis) young shoot extract Silver Linden (Tilia tomentosa) bud extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phyto-Gen Spm-gen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Juniper (Juniperus communis) young shoot extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper (Juniperus communis) young shoot extract full monograph & interactions

Silver Linden (Tilia tomentosa) bud extract1 drug type · 1 drug

Lithium

Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Linden is thought to have diuretic properties. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Silver Linden (Tilia tomentosa) bud extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phyto-Gen Spm-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Phyto-Gen Spm-gen by Genestra Brands: Common Questions

Does Phyto-Gen Spm-gen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Phyto-Gen Spm-gen has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phyto-Gen Spm-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — juniper is unsafe in pregnancy and should be avoided while breastfeeding. Linden safety isn't well studied in pregnancy or lactation, and English holly has no safety data for either. Talk with your doctor or pharmacist for personalized advice.
What is juniper supposed to do?
The data we hold doesn't establish that juniper is effective for any particular condition. It's been studied for GERD, rheumatoid arthritis, urinary tract infections, wound healing, kidney stones, and bronchitis, but the evidence is insufficient to rate it for any of these.
Will this product irritate my stomach?
English holly leaf can cause stomach irritation, diarrhea, nausea, and vomiting. Juniper and linden are generally well tolerated at low doses short-term, though juniper shouldn't be used long-term because it may irritate your kidneys.
Can I take this if I'm on a water pill or diabetes medication?
Not without checking first. Juniper may lower blood sugar and amplify the effects of diuretics, and both juniper and linden may affect lithium levels. Talk with your doctor or pharmacist before starting — they can tell you whether it's safe for your situation.
What are the inactive ingredients?
The liquid contains water, ethanol, and glycerin as inactive ingredients — no added dyes, artificial flavors, or common allergens are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phyto-Gen Spm-gen is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phyto-Gen Spm-gen label
Go deeper

The Full Monographs Behind Phyto-Gen Spm-gen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph → Herb & supplement monograph

Linden

Interacts with 1 drug

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evidence for these uses is lacking, but the...

Read the full Linden monograph → Herb & supplement monograph

Holly

Holly (Ilex aquifolium) is a common ornamental shrub whose bright red berries are poisonous and should never be eaten. There is very little reliable human evidence supporting any health bene...

Read the full Holly monograph →
Sources

Sources & How We Checked

Phyto-Gen Spm-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Juniper 7 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  5. Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
  6. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  7. Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed

See these in context on the Juniper monograph →

Linden 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

See these in context on the Linden monograph →

Holly 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Holly monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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