Inflammation Control 450 mg Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Inflammation Control 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Inflammation Control 450 mg is a dietary supplement by TerraVita Premium Collection with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis pain, lower back pain, joint pain and stiffness.Based on those ingredients, 1,048 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw, Boldo. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Inflammation Control 450 mg by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Inflammation Control 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Inflammation Control 450 mg by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Inflammation Control 450 mg contains 2 active ingredients: Devil's Claw and Boldo, delivered in a capsule form. Devil's Claw is traditionally used for back pain and osteoarthritis, while Boldo has been used in herbal medicine for various conditions, though the evidence for most of its traditional uses isn't yet established.
The capsule itself is made of gelatin and water.
Does it work?
Moderate evidence
Devil's Claw is possibly effective for back pain and osteoarthritis based on available evidence. For back pain specifically, the data supports a "possibly effective" rating.
The evidence for Devil's Claw in atherosclerosis is insufficient to rate. Boldo's effectiveness for benign prostatic hyperplasia, gallbladder disease, kidney stones, and joint pain all lack enough reliable evidence to rate — we simply don't know yet whether it works for these uses.
How safe is it?
Well-documented data
Devil's Claw is generally well tolerated for short-term use in healthy adults, though it can cause digestive upset including diarrhea, indigestion, and allergic skin reactions. Rarely, gastrointestinal bleeding has been reported.
Boldo is generally well tolerated at food-level amounts, but at medicinal doses it carries a real risk of liver damage due to ascaridole, a toxin in the leaf. The most common side effects of Boldo are abdominal pain, nausea, and vomiting.
Devil's Claw should be avoided during pregnancy because it may affect the uterus, and there's not enough safety data for breastfeeding. Boldo is considered possibly unsafe in pregnancy (it may stimulate the uterus) and should be avoided while breastfeeding due to insufficient safety information.
Meds to double-check
Moderate interaction found
If you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), medications processed by your liver's CYP2C9, CYP2C19, or CYP3A4 enzymes, the mood stabilizer lithium, the transplant drug tacrolimus, or stomach acid–reducing drugs (H2-blockers or proton pump inhibitors), check with your doctor or pharmacist before taking this product. These are the medication types with documented interactions to Devil's Claw, Boldo, or both.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product pairs two herbal ingredients with a track record of digestive and potential liver side effects, plus a significant interaction profile affecting blood thinners, liver-processing drugs, and several other medication types. It may be worth considering if you're looking at Devil's Claw specifically for back pain or osteoarthritis, but only if you're not pregnant or breastfeeding and don't take medications that interact with it.
Check your exact medications with the tool on this page and talk with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Inflammation Control 450 mg, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435163631 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 290036 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Inflammation Control 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 450 mg | -- |
| Devil's Claw | 0 NP | -- |
| Boldo | 0 NP | -- |
Other ingredients: Gelatin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2006 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Formula
Boldo Leaf and Devil's Claw
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Inflammation Control 450 mg by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Inflammation Control 450 mg by TerraVita Premium Collection
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Devil's Claw
- › Boldo
Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Inflammation Control 450 mg by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
Inflammation Control 450 mg by TerraVita Premium Collection contains two active ingredients — Devil's Claw and Boldo — and both have documented interactions with medications.
The most serious concern is Boldo's interaction with drugs that can harm the liver (hepatotoxic drugs); Boldo itself contains a liver toxin called ascaridole, and taking it alongside other drugs that stress the liver raises the risk of liver injury.
Read the full breakdown — every affected drug type, severity by severity
Devil's Claw interacts with several medication types through how your body breaks them down (cytochrome P450 enzyme systems). It may theoretically increase levels of drugs metabolized by CYP2C19, CYP2C9, and CYP3A4 — these enzymes process hundreds of common medications, from statins to antidepressants to antihistamines.
There's also a case report of a patient on the blood thinner warfarin (Coumadin) who developed bruising when taking Devil's Claw, suggesting it may boost warfarin's effect.
Boldo carries its own concerns with blood thinners (anticoagulants) and antiplatelet drugs — it may increase bleeding risk. It also interacts with the mood stabilizer lithium (it may reduce how your kidneys clear it, raising lithium levels) and the transplant rejection drug tacrolimus (it may lower tacrolimus levels, risking transplant failure).
Additionally, both Devil's Claw and Boldo may weaken stomach acid–reducing medications like H2-blockers and proton pump inhibitors (PPIs) by increasing stomach acid.
Altogether, these interactions span 1,049 individual medications. Use the medication checker on this page to look up your exact drugs before you start, and talk with your own doctor or pharmacist about whether this product is right for you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Inflammation Control 450 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Inflammation Control 450 mg interact with 1,048 drugs. Click any drug to see the details.
2 of the 2 ingredients in Inflammation Control 450 mg interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw Boldo
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Abiraterone interactionBoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Abiraterone Acetate interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo + Abrocitinib interactionDevil's ClawCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
Read the full Devil's Claw + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo + Acetaminophen, Aspirin, Caffeine interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Butalbital, Caffeine interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Butalbital, Caffeine, Codeine interactionBoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Inflammation Control 450 mg — through 1 ingredient. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Codeine interactionBoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Codeine, Salicylamide interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Dihydrocodeine interactionBoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Isometheptene interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
Devil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Caffeine, Pyrilamine interactionBoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Inflammation Control 450 mg — through 2 ingredients. Tap an ingredient for the detail:
BoldoHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDevil's ClawCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Inflammation Control 450 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Devil's Claw
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.
Warfarin (Coumadin)
Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.
H2-Blockers
Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.
P-Glycoprotein Substrates
Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.
Proton Pump Inhibitors (Ppis)
Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.
Boldo
Anticoagulant/Antiplatelet Drugs
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.
Hepatotoxic Drugs
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.
Lithium
Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.
Tacrolimus (Prograf)
Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.
Warfarin (Coumadin)
A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.
Brand information
Manufacturer and brand details for Inflammation Control 450 mg, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Inflammation Control 450 mg by TerraVita Premium Collection: Common Questions
Does Inflammation Control 450 mg by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Is Devil's Claw actually effective for back pain and arthritis?
Does this product have any filler ingredients?
Why is Boldo a concern for my liver?
What does the Proprietary Blend mean on the label?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Inflammation Control 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Devil's Claw
Interacts with 804 drugsDevil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...
Read the full Devil's Claw monograph → Herb & supplement monographBoldo
Interacts with 482 drugsBoldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...
Read the full Boldo monograph →Sources & How We Checked
Inflammation Control 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Devil's Claw 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
- Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
- Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
- Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
- Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
- Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
- Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
- Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
- Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
- Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
- Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
- Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
- Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
- Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.
Boldo 10 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
- Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
- Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
- Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
- Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
- Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC