Inflammation Control Vanilla Flavor Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking Inflammation Control Vanilla Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Inflammation Control Vanilla Flavor is a dietary supplement by TerraVita with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis pain, lower back pain, joint pain and stiffness.Based on those ingredients, 1,048 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw Glycerite Liquid Extract, Boldo Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Inflammation Control Vanilla Flavor by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with Inflammation Control Vanilla Flavor by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Inflammation Control Vanilla Flavor by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 2 active ingredients in liquid extract form: devil's claw glycerite and boldo glycerite. Devil's claw is traditionally used to support back and joint health, while boldo is included for its role in digestive and gallbladder function.
The product also contains glycerin and vanilla flavor as inactive ingredients.
Does it work?
Moderate evidence
Devil's claw is rated possibly effective for back pain and osteoarthritis, based on available evidence. Boldo, however, has insufficient reliable evidence in our data for the conditions it's used for — benign prostatic hyperplasia, gallbladder disease, kidney stones, and joint pain — so we cannot say whether it works for these purposes.
How safe is it?
Well-documented data
Devil's claw is generally well tolerated for short-term use in healthy adults, though it commonly causes digestive upset including diarrhea and indigestion. Rare cases of gastrointestinal bleeding have been reported.
Boldo is generally well tolerated in food amounts, but medicinal doses can cause serious liver injury; the ascaridole it contains is a known liver toxin, and multiple cases of elevated liver enzymes and jaundice have been documented. Both ingredients are rated possibly unsafe in pregnancy because they may affect the uterus, and neither has enough safety data for breastfeeding — the safety data advises against both during pregnancy and lactation.
Meds to double-check
Moderate interaction found
Before you take this product, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), lithium, tacrolimus, any drug broken down by your liver (CYP2C9, CYP2C19, or CYP3A4 substrates — ask your pharmacist if unsure), stomach acid reducers (H2-blockers like famotidine or proton pump inhibitors like omeprazole), or any drug that may harm the liver.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is best used short-term under professional guidance, especially because of boldo's liver-injury risk and devil's claw's effects on liver metabolism. If you take any blood thinners, lithium, tacrolimus, stomach acid reducers, or drugs metabolized by your liver, or if you have liver disease, talk with your doctor or pharmacist before starting.
Pregnant and breastfeeding people should avoid it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Inflammation Control Vanilla Flavor, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Inflammation Control Vanilla Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0.13 mL | -- |
| Devil's Claw Glycerite Liquid Extract | 0 NP | -- |
| Boldo Glycerite Liquid Extract | 0 NP | -- |
Other ingredients: Glycerin, Vanilla flavor
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Inflammation Control Vanilla Flavor by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Inflammation Control Vanilla Flavor by TerraVita
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Glycerin, Vanilla flavor. These complete the product’s ingredient list but are not active constituents.
Inflammation Control Vanilla Flavor by TerraVita Drug Interactions
HelloPharmacist Interaction Report
TerraVita's Inflammation Control Vanilla Flavor contains devil's claw and boldo, both of which carry documented interactions with medications.
The most serious finding involves boldo's potential to harm the liver (hepatotoxicity), especially when combined with drugs that are themselves toxic to the liver.
Read the full breakdown — every affected drug type, severity by severity
Devil's claw may theoretically increase blood levels of drugs broken down by your liver through three main pathways (CYP2C19, CYP2C9, and CYP3A4 substrates), all rated Moderate severity. It also carries a Moderate risk with blood thinners like warfarin — one case report described bleeding (purpura) in a patient taking both together, though it's unclear whether devil's claw alone was responsible.
Additionally, devil's claw may weaken stomach acid reducers (H2-blockers and proton pump inhibitors) because it can increase stomach acid; both are Minor severity.
Boldo presents Moderate-severity risks with blood thinners and antiplatelet drugs (increased bleeding risk), lithium (higher lithium levels), and the immunosuppressant tacrolimus (lower drug levels, transplant rejection risk). It also carries Moderate risk with any drug that can harm the liver.
At Minor severity, boldo may increase levels of drugs that depend on a cellular transporter called P-glycoprotein.
Altogether, these interactions span 1,049 individual medications. Use the search tool on this page to check your exact medications before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Inflammation Control Vanilla Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Inflammation Control Vanilla Flavor interact with 1,048 drugs. Click any drug to see the details.
2 of the 2 ingredients in Inflammation Control Vanilla Flavor interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw Glycerite Liquid Extract Boldo Glycerite Liquid Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo Glycerite Liquid Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Abiraterone interactionBoldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Abiraterone Acetate interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo Glycerite Liquid Extract + Abrocitinib interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
Read the full Devil's Claw Glycerite Liquid Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo Glycerite Liquid Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionBoldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Inflammation Control Vanilla Flavor — through 1 ingredient. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine interactionBoldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionBoldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Devil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Caffeine, Pyrilamine interactionBoldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Inflammation Control Vanilla Flavor — through 2 ingredients. Tap an ingredient for the detail:
Boldo Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDevil's Claw Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Inflammation Control Vanilla Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Devil's Claw Glycerite Liquid Extract
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.
Warfarin (Coumadin)
Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.
H2-Blockers
Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.
P-Glycoprotein Substrates
Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.
Proton Pump Inhibitors (Ppis)
Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.
Boldo Glycerite Liquid Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.
Hepatotoxic Drugs
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.
Lithium
Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.
Tacrolimus (Prograf)
Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.
Warfarin (Coumadin)
A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.
Brand information
Manufacturer and brand details for Inflammation Control Vanilla Flavor, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
Inflammation Control Vanilla Flavor by TerraVita: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Inflammation Control Vanilla Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Devil's Claw
Interacts with 804 drugsDevil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...
Read the full Devil's Claw monograph → Herb & supplement monographBoldo
Interacts with 482 drugsBoldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...
Read the full Boldo monograph →Sources & How We Checked
Inflammation Control Vanilla Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Devil's Claw 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
- Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
- Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
- Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
- Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
- Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
- Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
- Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
- Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
- Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
- Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
- Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
- Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
- Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.
Boldo 10 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
- Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
- Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
- Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
- Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
- Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC