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Dietary supplement

Ipriflavone 600 mg Ingredients & Drug Interactions

by Specialty Pharmacy

Ipriflavone 600 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ipriflavone 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ipriflavone 600 mg is a dietary supplement by Specialty Pharmacy with 1 active ingredient. Its ingredients are commonly taken for bone density and osteoporosis, postmenopausal bone loss, athletic performance.Based on those ingredients, 391 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ipriflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ipriflavone 600 mg by Specialty Pharmacy

Ask about any prescription or over-the-counter medication and we check it for interactions with Ipriflavone 600 mg by Specialty Pharmacy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ipriflavone 600 mg by Specialty Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: ipriflavone, 600 mg per capsule. Ipriflavone is a synthetic compound derived from soy that's studied for its effects on bone metabolism.

The capsule itself is made of gelatin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone density and osteoporosis support.
  • We looked for evidence on: Osteoporosis, postmenopausal bone loss, bone health.
  • The strongest evidence on file: Ipriflavone is rated "Likely Effective" for Osteoporosis (Natural Medicines).

Ipriflavone is rated likely effective for osteoporosis and also for Paget disease (a bone disorder that causes abnormal bone remodeling). That said, the evidence we hold doesn't detail how well it works compared to other treatments or the typical size of benefit in real patients — talk with your doctor about whether it fits your situation.

The evidence, ingredient by ingredient Ipriflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ipriflavone is generally well tolerated when taken by mouth, but some people experience stomach pain, diarrhea, or dizziness. There's concern that long-term use (6 months or more) may lower white blood cell counts.

The product should be avoided during pregnancy due to possible estrogen-like effects, and it's best avoided during breastfeeding due to insufficient safety data. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Ipriflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ipriflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 391 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take theophylline (a breathing medication), drugs metabolized by CYP1A2 or CYP2C9 enzymes (including some antidepressants, muscle relaxants, and anti-anxiety medicines), or any immunosuppressant medications. Ipriflavone can raise levels of theophylline and many other drugs, raising the risk of side effects or toxicity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ipriflavone may help with osteoporosis and Paget disease, but it has significant interactions with common medications and can affect white blood cell counts with long-term use. If you take any prescription drugs — especially theophylline, muscle relaxants, antidepressants, anti-anxiety medicines, or immunosuppressants — clear it with your doctor or pharmacist before starting.

It's not for pregnant or breastfeeding individuals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ipriflavone 600 mg, straight from the product label.

Brand Specialty Pharmacy
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34641
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ipriflavone 600 mg by Specialty Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
IngredientAmount% DV
Ipriflavone600 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

CONTAINS NO ADDED: sugar, salt, dairy, yeast, wheat, corn, soy, preservative, artificial colors, flavors or any other binders or fillers.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, adults take three (3) capsules daily or as directed by a health care professional.

Precautions

Keep out of reach of children.

General

200

General Statements

Vitamins, Nutrition & Wellness

Seals/Symbols

SPECIALTY PHARMACY(TM)

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ipriflavone 600 mg by Specialty Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ipriflavone 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ipriflavone 600 mg by Specialty Pharmacy

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Ipriflavone

Interacts with
391 drugs
600 mg per serving

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...

Ipriflavone monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ipriflavone 600 mg by Specialty Pharmacy Drug Interactions

Want to check YOUR meds against Ipriflavone 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
391Drugs
391 Moderate

Ingredients driving the most interactions

Ipriflavone 391

Individual Drug Interactions

The ingredients in Ipriflavone 600 mg interact with 391 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ipriflavone 600 mg interact with drugs. Each result below shows which ingredient is responsible. Ipriflavone

Each ingredient & the kinds of drugs it affects

For each ingredient in Ipriflavone 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ipriflavone4 drug types · 391 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.

Likelihood Possible Evidence D
Immunosuppressants

Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence A
Theophylline

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence D
Ipriflavone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ipriflavone 600 mg, from the product label.

Specialty Pharmacy

See all Specialty Pharmacy products
Name
Specialty Pharmacy, Inc.
City
Flowood
State
Mississippi
ZipCode
39232
Phone Number
1-877-866-4979
Pharmacist Counseling Corner

Ipriflavone 600 mg by Specialty Pharmacy: Common Questions

Does Ipriflavone 600 mg by Specialty Pharmacy interact with any medications?
Yes. Based on its ingredients, Ipriflavone 600 mg has a known interaction with 391 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ipriflavone 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ipriflavone if I'm pregnant or breastfeeding?
No. Ipriflavone should be avoided during pregnancy because of possible estrogen-like effects and limited safety data. It's also best avoided while breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.
What side effects might I experience?
Most people tolerate it well, but some experience stomach pain, diarrhea, or dizziness. With long-term use (6 months or more), there's concern it may lower white blood cell counts, so your doctor may want to monitor that if you're taking it long-term.
Does ipriflavone actually work for osteoporosis?
Ipriflavone is rated likely effective for osteoporosis based on available evidence. It's also likely effective for Paget disease. However, the facts we hold don't detail how much benefit most people see or how it compares to other treatments — ask your doctor whether it's right for your situation.
Why is theophylline a special concern?
Ipriflavone slows how your liver breaks down theophylline (a breathing medication). When this happens, theophylline can build up in your blood to dangerous levels. Two patients actually experienced higher theophylline levels after starting ipriflavone, so if you take theophylline, your doctor needs to know before you start this product.
What's in the capsule besides ipriflavone?
The capsule is made of gelatin. There are no other active ingredients — just the 600 mg of ipriflavone and the capsule material itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ipriflavone 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ipriflavone 600 mg label
Go deeper

The Full Monographs Behind Ipriflavone 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ipriflavone

Interacts with 391 drugs

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...

Read the full Ipriflavone monograph →
Sources

Sources & How We Checked

Ipriflavone 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ipriflavone 6 references
  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

See these in context on the Ipriflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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