Iron Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Iron against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Iron is a dietary supplement by California Gold Nutrition with 2 active ingredients. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 156 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Iron, Yellow Dock. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Iron by California Gold Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Iron by California Gold Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Iron by California Gold Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains two active ingredients: iron and yellow dock. Iron is the main component—it's a mineral your body needs to make red blood cells and carry oxygen.
Yellow dock is a plant traditionally used as a mild laxative and source of minerals. The liquid also contains glycerin, deionized water, blackberry juice concentrate, citric acid, and natural flavors as inactive ingredients that give the supplement its form and taste.
Does it work?
Strong evidence
Iron is effective for treating iron deficiency anemia, anemia of chronic disease, and iron deficiency during pregnancy. There's also possibly effective evidence for iron in heart failure.
Yellow dock has no effectiveness ratings in our data, so we can't speak to what it does or doesn't accomplish in this product.
How safe is it?
Well-documented data
Iron is generally well tolerated when used at recommended doses, but excess iron can be toxic—supplements should only be used when there's a real need. The most common side effects when taken orally are abdominal pain, constipation, diarrhea, nausea, and vomiting.
Rare serious side effects include ulcerations of the stomach or intestines. Yellow dock may act as a laxative and contains oxalates.
It's best used short-term and with care. Raw yellow dock leaves or rhizomes can cause serious harm including low blood calcium (hypocalcemia), kidney stones, and vomiting.
Regarding pregnancy: iron is often recommended in pregnancy, but dosing should be guided by your prenatal care provider. Yellow dock is not advised during pregnancy—there isn't enough safety data.
While breastfeeding, iron is generally considered acceptable at appropriate doses, but yellow dock should be avoided because laxative compounds may pass into breast milk. Check with your healthcare provider for personalized guidance.
Meds to double-check
Major interaction found
Before taking this product, make sure your doctor or pharmacist knows about any of these medications: diuretics (water pills), digoxin (a heart medication), warfarin (a blood thinner), levodopa (for Parkinson's), antibiotics (especially quinolones and tetracyclines), bisphosphonates (bone medications), methyldopa (blood pressure), levothyroxine (thyroid), mycophenolate mofetil (immunosuppressant), and penicillamine (for Wilson's disease). All require careful timing with iron, and yellow dock poses additional risks with heart and blood medications.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This supplement is intended for iron deficiency anemia and related conditions. Because it contains yellow dock—a potent laxative with Major interactions involving heart and blood-thinning medications—and iron has Moderate interactions with many common drugs, you'll need to check your medications carefully before starting.
Talk with your doctor or pharmacist about dosing, timing, and whether this product is right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Iron, straight from the product label.
| Brand | California Gold Nutrition |
|---|---|
| Barcode (UPC) | 898220021161 |
| Net contents | 4 Fluid Ounce(s); 118 mL |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 299630 |
| Product type | Botanical With Nutrients |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Iron by California Gold Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 3 Gram(s) | 1% |
| Iron | 10 mg | 56% |
| Yellow Dock | 100 mg | -- |
Other ingredients: Glycerin, deionized Water, Blackberry juice concentrate, Citric Acid, Natural Flavors
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 teaspoon daily, with or without food. Best when taken as a directed by a qualified healthcare professional. Shake well before using.
Precautions
Warnings: keep out of reach of children.
Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
Pregnant or lactating women, the chronically ill, elderly, individuals under the age of 18, those taking prescription medications (e.g., blood thinners) as well as those with a physician-diagnosed medical condition should with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
Sealed for your protection. Do not use if seal is missing or broken.
Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third party audited, and cGMP compliant facility that may process other products that contain these allergens or ingredients.
Storage
Store in a cool, dry place. Protect from heat, light, and moisture.
Brand IP Statement(s)
California Gold Nutrition is a registered trademark of Madre Labs, LLC
Formulation
Formulated without: Gluten GMOs Soy
Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Iron by California Gold Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Iron by California Gold Nutrition
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Iron
Interacts with80 drugs
Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...
Iron monograph & interactionsYellow Dock
Interacts with78 drugs
Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefi...
Yellow Dock monograph & interactionsOther (inactive) ingredients: Glycerin, Deionized Water, Blackberry juice concentrate, Citric Acid, Natural Flavors. These complete the product’s ingredient list but are not active constituents.
Iron by California Gold Nutrition Drug Interactions
HelloPharmacist Interaction Report
California Gold Nutrition Iron liquid contains iron and yellow dock, and both ingredients carry documented interactions with medications.
The most serious concern is yellow dock's potential to increase the risk of digoxin toxicity (a heart medication) when used long-term or in large amounts, because yellow dock may lower potassium levels, which makes digoxin more dangerous.
Read the full breakdown — every affected drug type, severity by severity
Iron itself has Moderate interactions with several drug types. It can reduce absorption of levodopa (a Parkinson's medication), quinolone and tetracycline antibiotics, bisphosphonates (bone medications), methyldopa (a blood pressure drug), levothyroxine (a thyroid medication), mycophenolate mofetil (an immunosuppressant), and penicillamine (used for Wilson's disease).
All of these work best when separated from iron by at least 2 hours—some require 4–6 hours.
Yellow dock also carries a Moderate interaction with warfarin (a blood thinner); its laxative effect may increase bleeding risk if it causes diarrhea. Additionally, yellow dock may theoretically increase potassium loss when combined with diuretics (water pills).
Everything told, these interactions span 156 individual medications. Before you start this supplement, run your exact medications through the checker on this page or talk with your doctor or pharmacist to make sure the timing works.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Iron?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Iron interact with 156 drugs. Click any drug to see the details.
2 of the 2 ingredients in Iron interact with drugs. Each result below shows which ingredient is responsible. Iron Yellow Dock
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Acetazolamide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Ammonium Chloride interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Atenolol, Chlorthalidone interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Benzthiazide interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bisoprolol, Hydrochlorothiazide interactionBumetanideBurinex
How Bumetanide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Bumetanide, Potassium interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Caffeine, Potassium Salicylate, Salicylamide interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Iron — through 2 ingredients. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Chlorothiazide, Methyldopa interactionIronMethyldopa (aldomet) Moderate
Interaction Summary
Iron might decrease methyldopa levels by reducing its absorption.
Read the full Iron + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Chlorthalidone, Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Cyclothiazide interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDiuretic Drugs Major
Interaction Summary
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Deserpidine, Methyclothiazide interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Iron — through 1 ingredient. Tap an ingredient for the detail:
Yellow DockDigoxin (lanoxin) Major
Interaction Summary
Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
Read the full Yellow Dock + Digoxin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Iron with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Iron
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.
Bisphosphonates
Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.
Denosumab (Prolia, Others)
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.
Dolutegravir (Tivicay)
Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.
Integrase Inhibitors
Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.
Levodopa
Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.
Levothyroxine (Synthroid, Others)
Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.
Methyldopa (Aldomet)
Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.
Mycophenolate Mofetil (Cellcept)
Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.
Penicillamine (Cuprimine, Depen)
Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.
Quinolone Antibiotics
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.
Tetracycline Antibiotics
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.
Chloramphenicol
Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.
Yellow Dock
Digoxin (Lanoxin)
Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.
Diuretic Drugs
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.
Warfarin (Coumadin)
Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.
Brand information
Manufacturer and brand details for Iron, from the product label.
California Gold Nutrition
See all California Gold Nutrition products- Name
- Madre Labs, LLC
- Street Address
- 17400 Laguna Canyon Rd. Suite 400
- City
- Irvine
- State
- CA
- ZipCode
- 92618
- Web Address
- www.calgn.com
Iron by California Gold Nutrition: Common Questions
Does Iron by California Gold Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Why do I need to space this 2 hours away from my antibiotics?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Iron is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Iron’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Iron
Interacts with 80 drugsIron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...
Read the full Iron monograph → Herb & supplement monographYellow Dock
Interacts with 78 drugsYellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...
Read the full Yellow Dock monograph →Sources & How We Checked
Iron's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 80 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Iron 72 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
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