Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Isatis 6 Ingredients & Drug Interactions

by Seven Forests

Isatis 6 label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Isatis 6 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Isatis 6 is a dietary supplement by Seven Forests with 6 active ingredients. Its ingredients are commonly taken for source of resveratrol, heart and circulation support, inflammation.Based on those ingredients, 1,057 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hu Zhang, Chuan Xin Lian, Jin Yin Hua. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Isatis 6 by Seven Forests

Ask about any prescription or over-the-counter medication and we check it for interactions with Isatis 6 by Seven Forests — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Isatis 6 by Seven Forests

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.

Isatis 6 contains six active ingredients rooted in traditional Chinese medicine: Da Qing Ye, hu zhang (Japanese knotweed), Xia Ku Cao (self-heal), Bai Hua She She Cao, andrographis (Chuan Xin Lian), and honeysuckle (Jin Yin Hua). Hu zhang is thought to support liver function and contains resveratrol, an antioxidant.

Andrographis has been studied for immune and inflammatory support. Self-heal, honeysuckle, and the other ingredients are traditionally used to address various aspects of immune and respiratory wellness.

There are no inactive ingredients listed for this product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Ulcerative colitis — rated "Possibly Effective" (Andrographis) (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Andrographis) (Natural Medicines).
  • On file: Tonsillopharyngitis — rated "Possibly Effective" (Andrographis) (Natural Medicines).

The evidence we hold is limited. Andrographis shows "possibly effective" ratings for ulcerative colitis, tonsillopharyngitis, and osteoarthritis—meaning some clinical support exists, though it's not conclusive.

For hu zhang, self-heal, honeysuckle, and the other ingredients in this formula, the evidence for their individual uses (hepatitis, rheumatoid arthritis, wound healing, gout, respiratory infections, and others) is rated insufficient—we don't yet have reliable data to confirm they work for these purposes. This product is a traditional formula; if you're looking for it to address a specific health concern, talk it over with your doctor or pharmacist to see if the evidence supports that use.

The evidence, ingredient by ingredient Hu Zhang Self-heal Andrographis Honeysuckle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andrographis is generally well tolerated in the short term, though long-term safety isn't well established. At higher doses or longer use, it may cause nausea, diarrhea, abdominal discomfort, headache, fatigue, dizziness, rash, or itching; rare severe allergic reactions, including anaphylaxis, have been reported.

Hu zhang may cause digestive upset due to its emodin content. Self-heal and honeysuckle have limited human safety data but are traditionally used as foods and teas; self-heal has been reported to cause nausea, vomiting, diarrhea, and allergic reactions in sensitive people, and honeysuckle has caused contact dermatitis and allergic drug eruptions in isolated cases.

Pregnancy and breastfeeding: Andrographis is rated possibly unsafe in pregnancy due to theoretical and animal concerns about reproductive effects, so avoid it if you are or may be pregnant. Hu zhang, self-heal, and honeysuckle all lack enough safety data in pregnancy and breastfeeding—the facts advise against them during these times.

If you are pregnant, breastfeeding, or planning to become pregnant, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Hu Zhang Self-heal Andrographis Honeysuckle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Honeysuckle, Andrographis, Hu Zhang.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 1,058 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Isatis 6, double-check with your pharmacist or doctor if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—hu zhang, andrographis, and honeysuckle may increase bleeding risk. Also verify if you're on blood pressure medications, immune suppressants, estrogen replacement, or liver enzyme substrates (including many cholesterol drugs, some cancer medications, and others), as hu zhang and andrographis may affect how these work.

If you take carbamazepine (Tegretol), diabetes medications, or certain pain relievers like celecoxib (Celebrex), those interactions should be reviewed as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Isatis 6 is a traditional herbal formula with limited high-quality evidence for its intended uses and moderate interaction risks, especially if you take blood thinners, blood pressure medications, immune-suppressing drugs, or medications processed through certain liver enzymes. Andrographis carries pregnancy safety concerns.

If you're considering this product—particularly if you take any regular medications, are pregnant, breastfeeding, or have a bleeding disorder—discuss it with your doctor or pharmacist first to make sure it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Isatis 6, straight from the product label.

Brand Seven Forests
Net contents 175 Gram(s); 250 Tablet(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 206138
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Isatis 6 by Seven Forests, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Not Present
Maximum serving Sizes:
3 Not Present
IngredientAmount% DV
Da Qing Ye0 NP--
Hu Zhang0 NP--
Xia Ku Cao0 NP--
Bai Hua She She Cao0 NP--
Chuan Xin Lian0 NP--
Jin Yin Hua0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Da Qing Jie Du Pian

175 g - 250 tablets/700 mg each

Herbal food combination

Suggested/Recommended/Usage/Directions

Isatis 6 dosage Take 2-3 tablets, three times a day, best on an empty stomach, or as prescribed

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Isatis 6 by Seven Forests label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Isatis 6 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Isatis 6 by Seven Forests

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Not Present Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Da Qing Ye

0 NP per serving

Hu Zhang

Interacts with
826 drugs
0 NP per serving

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...

Hu Zhang monograph & interactions

Xia Ku Cao

No known
interactions
0 NP per serving

Self-heal (Prunella vulgaris) is a traditional herb used for sore throats, skin issues, and inflammation, mainly in folk and traditional Chinese medic...

Xia Ku Cao monograph & interactions

Bai Hua She She Cao

0 NP per serving

Chuan Xin Lian

Interacts with
413 drugs
0 NP per serving

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Chuan Xin Lian monograph & interactions

Jin Yin Hua

Interacts with
122 drugs
0 NP per serving

Honeysuckle, especially Japanese honeysuckle flower (Lonicera japonica), is a staple of traditional Chinese medicine used mainly for colds, sore throa...

Jin Yin Hua monograph & interactions
Interaction report

Isatis 6 by Seven Forests Drug Interactions

Want to check YOUR meds against Isatis 6?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,057Drugs
1,054 Moderate 3 Minor

Ingredients driving the most interactions

Hu Zhang 826
Chuan Xin Lian 413
Jin Yin Hua 122

Individual Drug Interactions

The ingredients in Isatis 6 interact with 1,057 drugs. Click any drug to see the details.

3 of the 6 ingredients in Isatis 6 interact with drugs. Each result below shows which ingredient is responsible. Hu Zhang Chuan Xin Lian Jin Yin Hua

Each ingredient & the kinds of drugs it affects

For each ingredient in Isatis 6 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hu Zhang7 drug types · 826 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Estrogens

Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Hu Zhang full monograph & interactions

Chuan Xin Lian6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Chuan Xin Lian full monograph & interactions

Jin Yin Hua1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that polyphenols extracted from honeysuckle can inhibit platelet aggregation.

Likelihood Possible Evidence D
Jin Yin Hua full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Isatis 6, from the product label.

Seven Forests

See all Seven Forests products
Name
I.T.M.
Street Address
2017 SE Hawthorne
City
Portland
State
Oregon
ZipCode
97214
Pharmacist Counseling Corner

Isatis 6 by Seven Forests: Common Questions

Does Isatis 6 by Seven Forests interact with any medications?
Yes. Based on its ingredients, Isatis 6 has a known interaction with 1,057 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Isatis 6 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Isatis 6 if I'm pregnant or breastfeeding?
No. Andrographis in this formula is rated possibly unsafe in pregnancy because of theoretical and animal concerns about reproductive effects. Hu zhang, self-heal, and honeysuckle all lack enough safety data during pregnancy and breastfeeding, and the product information advises against them. Talk with your doctor or pharmacist before taking this product if you are pregnant, breastfeeding, or planning to become pregnant.
What side effects might I notice?
Andrographis may cause nausea, diarrhea, abdominal discomfort, headache, fatigue, dizziness, or rash, especially at higher doses. Hu zhang may cause digestive upset. Self-heal and honeysuckle can trigger nausea, vomiting, diarrhea, or allergic reactions in some people. Serious allergic reactions are rare but have been reported with andrographis.
Does this product actually work for the conditions it's used for?
The evidence varies. Andrographis has some clinical support for ulcerative colitis, tonsillopharyngitis, and osteoarthritis—rated possibly effective. For hu zhang, self-heal, honeysuckle, and other uses listed (hepatitis, wound healing, gout, respiratory infections), the evidence in our data is insufficient to confirm they work. This is a traditional formula; if you want to use it for a specific condition, discuss the evidence and whether it's right for you with your doctor or pharmacist.
What is andrographis (Chuan Xin Lian) in this product?
Andrographis is a traditional herb believed to support immune and inflammatory response. It's been studied most for conditions like ulcerative colitis and sore throat, though long-term safety data are limited and quality varies among products.
Why does this product interact with so many medications?
Hu zhang contains resveratrol, which may slow how your liver breaks down drugs processed through three major enzyme systems (CYP1A2, CYP2C19, and CYP3A4), potentially raising drug levels. Additionally, hu zhang, andrographis, and honeysuckle all have antiplatelet or blood-thinning properties that compound with anticoagulant and antiplatelet medications. These are mostly theoretical risks based on lab and animal research, but they're worth checking before you start.
Are there any ingredients in Isatis 6 with no known medication interactions?
Yes. Self-heal (Xia Ku Cao) was checked and has no documented interactions with medications in our data. We could not check Da Qing Ye or Bai Hua She She Cao because we hold no interaction information for them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Isatis 6 label
Go deeper

The Full Monographs Behind Isatis 6’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hu Zhang

Interacts with 826 drugs

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...

Read the full Hu Zhang monograph → Herb & supplement monograph

Self-heal

Self-heal (Prunella vulgaris) is a traditional herb used for sore throats, skin issues, and inflammation, mainly in folk and traditional Chinese medicine. Human evidence for its benefits is...

Read the full Self-heal monograph → Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph → Herb & supplement monograph

Honeysuckle

Interacts with 122 drugs

Honeysuckle, especially Japanese honeysuckle flower (Lonicera japonica), is a staple of traditional Chinese medicine used mainly for colds, sore throat, and inflammation. Modern human eviden...

Read the full Honeysuckle monograph →
Sources

Sources & How We Checked

Isatis 6's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 50 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hu Zhang 19 references
  1. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  2. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  3. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  4. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  5. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  6. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  7. Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
  8. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  9. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  10. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  11. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  12. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  13. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  14. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  15. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  16. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  17. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  18. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  19. Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. PubMed

See these in context on the Hu Zhang monograph →

Self-heal 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Song YW, Lee EY, Koh EM, et al. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clini

See these in context on the Self-heal monograph →

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
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  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
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  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
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Honeysuckle 3 references
  1. Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids 1992;45:307-12. PubMed
  2. Webster RM. Honeysuckle contact dermatitis. Cutis 1993;51:424.
  3. Zhou LF, Lu R. Compound-honeysuckle-induced drug eruption with special manifestations: A case report. World J Clin Cases 2022;10(22):8018-8024. PubMed

See these in context on the Honeysuckle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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