Joint Relief 911 Ingredients & Drug Interactions
by PhytAge Labs
What is this page for?
First and foremost: checking Joint Relief 911 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Joint Relief 911 is a dietary supplement by PhytAge Labs with 2 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis paniculata 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Joint Relief 911 by PhytAge Labs
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Joint Relief 911 by PhytAge Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Joint Relief 911 contains two active ingredients: hyaluronic acid and andrographis paniculata 4:1 extract. Hyaluronic acid is a naturally occurring compound found in connective tissue; it's used here for joint support.
Andrographis is a plant extract traditionally used for inflammation and immune support. The product also contains inactive ingredients — rice powder, gelatin, magnesium stearate, and silica — that serve as fillers and capsule material.
Does it work?
Moderate evidence
For hyaluronic acid, the evidence we have supports use for dry eye and venous leg ulcers (slow-healing leg wounds), both rated Possibly Effective. For aging skin, hay fever, and sexual dysfunction, there isn't enough reliable evidence to rate it either way.
For andrographis, the data shows Possibly Effective ratings for ulcerative colitis (inflammatory bowel disease), sore throat (tonsillopharyngitis), and osteoarthritis (joint wear and tear). Familial Mediterranean fever (a rare inherited inflammatory condition) lacks enough evidence to rate.
This product is marketed for joint relief; the andrographis component has some evidence for osteoarthritis, but we hold no specific effectiveness data for the combination as a joint supplement.
How safe is it?
Well-documented data
Hyaluronic acid is generally well tolerated orally and topically, though long-term safety of oral supplements hasn't been fully studied — the safety notes on file advise caution and recommend avoiding oral supplements unless your doctor clears it. Andrographis is often well tolerated short-term, but quality varies and long-term safety isn't well established.
Common side effects from andrographis include stomach discomfort, altered taste, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, rash, and hives; serious allergic reactions including anaphylaxis are rare. High doses and longer use (over 14 days) make side effects more likely.
Andrographis is rated Possibly Unsafe in pregnancy due to theoretical concerns and animal study findings, so avoid it if you're pregnant; there's not enough safety information for breastfeeding, so avoid it then too. Hyaluronic acid has no pregnancy or lactation data on file.
Meds to double-check
Moderate interaction found
If you take blood pressure medications (antihypertensives), blood thinners (anticoagulants or antiplatelets), or immune-suppressing drugs (immunosuppressants), check with your doctor or pharmacist before taking Joint Relief 911 — andrographis may increase the effect of blood pressure drugs and blood thinners, raising the risk of low blood pressure or bleeding, and it may reduce how well immune-suppressing drugs work. Also flag any use of etoricoxib (Arcoxia), celecoxib (Celebrex), or glipizide (Glucotrol), as andrographis may change how your body handles these medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Joint Relief 911 contains two ingredients with different safety and interaction profiles — hyaluronic acid is well tolerated with no known drug interactions, but andrographis has documented Moderate interactions with blood pressure, blood-thinning, and immune medications, plus Minor interactions with a few pain and blood sugar drugs. If you're pregnant or breastfeeding, talk with your doctor about andrographis before taking this product.
Before starting, especially if you take prescription medications, discuss it with your doctor or pharmacist to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Joint Relief 911, straight from the product label.
| Brand | PhytAge Labs |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 276433 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Joint Relief 911 by PhytAge Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hyaluronic Acid | 30 mg | -- |
| Andrographis paniculata 4:1 extract | 250 mg | -- |
Other ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use As a dietary supplement, take two capsules daily with a meal or as directed by your healthcare practitioner.
Precautions
Warning Not for use by persons under the age of 18.
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
100% satisfaction 5 stars guarantee
Formulation
Healthy joint support formula
+ Supports joint health + Joint mobility & flexibility + Joint strength & lubrication 100% natural
Formula
+ Andrographis paniculata and hyaluronic acid
Seals/Symbols
Made In The USA
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Joint Relief 911 by PhytAge Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Joint Relief 911 by PhytAge Labs
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hyaluronic Acid
No knowninteractions
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...
Hyaluronic Acid monograph & interactionsAndrographis paniculata 4:1 extract
Interacts with413 drugs
Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...
Andrographis paniculata 4:1 extract monograph & interactionsOther (inactive) ingredients: Rice, Powder, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Joint Relief 911 by PhytAge Labs Drug Interactions
HelloPharmacist Interaction Report
Joint Relief 911 by PhytAge Labs contains hyaluronic acid and andrographis paniculata extract.
Hyaluronic acid shows no documented interactions with medications. Andrographis, however, interacts with several drug types — most seriously with blood pressure medications (antihypertensives), blood thinners (anticoagulants and antiplatelets), and immune-suppressing drugs (immunosuppressants), all at Moderate severity.
Through andrographis, the product may lower your blood pressure or increase bleeding risk if you're on those medications, and it may interfere with how your body handles immunosuppressants.
Read the full breakdown — every affected drug type, severity by severity
Andrographis also has Minor interactions with three specific drugs: etoricoxib (Arcoxia), a pain reliever; celecoxib (Celebrex), another pain reliever; and glipizide (Glucotrol), a blood sugar medication. With etoricoxib, andrographis may reduce how much of the drug your body absorbs.
With celecoxib and glipizide, the interactions are less clear but andrographis may change how quickly and how much of these drugs reach your bloodstream.
Altogether, these interactions span 413 individual medications. Before you start Joint Relief 911, check your exact prescription medications with your doctor or pharmacist — especially if you take anything for blood pressure, bleeding prevention, immune function, or blood sugar control.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Joint Relief 911?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Joint Relief 911 interact with 413 drugs. Click any drug to see the details.
1 of the 2 ingredients in Joint Relief 911 interact with drugs. Each result below shows which ingredient is responsible. Andrographis paniculata 4:1 extract
Aspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata 4:1 Extract + Aspirin, Pentazocine interactionAtenololAtenix, Tenormin
How Atenolol interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Atenolol, Chlorthalidone interactionAtezolizumabTecentriq
How Atezolizumab interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Azathioprine interactionAzilsartanEdarbi
How Azilsartan interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Azilsartan, Chlorthalidone interactionBasiliximabSimulect
How Basiliximab interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Basiliximab interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Beclomethasone Dipropionate interactionBenazeprilLotensin
How Benazepril interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Joint Relief 911 — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata 4:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata 4:1 Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Joint Relief 911 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Andrographis paniculata 4:1 extract
Anticoagulant/Antiplatelet Drugs
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.
Antihypertensive Drugs
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.
Immunosuppressants
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.
Celecoxib (Celebrex)
Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.
Etoricoxib (Arcoxia)
Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.
Glipizide (Glucotrol)
Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.
Brand information
Manufacturer and brand details for Joint Relief 911, from the product label.
PhytAge Labs
See all PhytAge Labs products- Name
- PhytAge Laboratories
- Street Address
- 37 Inverness Drive East, Suite 100
- City
- Englewood
- State
- CO
- ZipCode
- 80112
- Phone Number
- 1-800-822-5753
Joint Relief 911 by PhytAge Labs: Common Questions
Does Joint Relief 911 by PhytAge Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe to use while breastfeeding?
What are the most common side effects?
Does hyaluronic acid in this product help with joint pain?
How long can I safely take this?
Will this interact with my pain reliever?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Joint Relief 911 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Joint Relief 911’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph → Herb & supplement monographAndrographis
Interacts with 413 drugsAndrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...
Read the full Andrographis monograph →Sources & How We Checked
Joint Relief 911's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Andrographis 26 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
- Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
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