Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Joint Remedy Omega Swirl Mountain Berry Ingredients & Drug Interactions

by Barlean's

Joint Remedy Omega Swirl Mountain Berry label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Joint Remedy Omega Swirl Mountain Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Joint Remedy Omega Swirl Mountain Berry is a dietary supplement by Barlean's with 4 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 764 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Joint Remedy Omega Swirl Mountain Berry by Barlean's

Ask about any prescription or over-the-counter medication and we check it for interactions with Joint Remedy Omega Swirl Mountain Berry by Barlean's — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Joint Remedy Omega Swirl Mountain Berry by Barlean's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.

This product has 6 active ingredients. The main ones are omega fatty acids — polyunsaturated fat, monounsaturated fat, and a proprietary Omega-7 blend (Provinal) — which support joint and general health.

It also contains vitamin E, an antioxidant that your body uses to protect cells from damage, and hyaluronic acid, a substance found naturally in skin and joints that helps retain moisture. The rest is made up of inactive ingredients like water, xylitol for sweetness, gums for texture, and natural flavors to make the liquid palatable.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Joint health and comfort support.
  • We looked for evidence on: Osteoarthritis, Joint mobility, Cartilage health, Joint flexibility.
  • The closest evidence on file: Vitamin E is rated "Possibly Ineffective" for Osteoarthritis (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

Vitamin E is effective for treating vitamin E deficiency and a rare genetic condition called AVED (ataxia with vitamin E deficiency). It's possibly effective for Alzheimer disease, beta-thalassemia, and G6PD deficiency, and for preventing intracranial hemorrhage.

Hyaluronic acid is possibly effective for dry eye and venous leg ulcers; for aging skin, allergic rhinitis, and sexual dysfunction, the evidence we hold is insufficient to rate it. We don't have established effectiveness data for the other ingredients in this product.

The evidence, ingredient by ingredient Vitamin E Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E at usual dietary amounts is safe, but high-dose long-term supplements may raise your risk of bleeding and other harms. The safety data advises against high-dose supplements during pregnancy unless your doctor directs otherwise; amounts from food and prenatal vitamins are fine.

While breastfeeding, normal dietary amounts are safe, but check with your doctor before taking high-dose supplements. Vitamin E is generally well tolerated when taken orally, though rare serious side effects include bleeding and hemorrhagic stroke, especially in male smokers at higher doses.

Hyaluronic acid is generally well tolerated orally and topically, but long-term safety of supplements hasn't been fully studied, and there isn't enough safety data on oral supplements — the safety facts advise avoiding them unless your doctor approves. Pregnancy and breastfeeding safety data for hyaluronic acid isn't on file.

Side effects, ingredient by ingredient Vitamin E Hyaluronic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 765 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk of increased bleeding), alkylating agent or antitumor antibiotic chemotherapy drugs (moderate risk of reduced effectiveness), CYP3A4 substrate medications (moderate risk of reduced drug levels), cyclosporine (moderate risk of increased levels), selumetinib (moderate risk of bleeding), or niacin (minor risk of reduced cholesterol benefit). These are the medication types documented to interact with vitamin E, the only ingredient in this product we could check for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This liquid omega supplement is aimed at joint health through its omega fatty acids and hyaluronic acid content. If you take blood thinners, cancer medications, or cyclosporine, you'll want to talk with your doctor or pharmacist before starting, because vitamin E in this product may interact with them.

Anyone taking high-dose vitamin E or concerned about bleeding risk should also check with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Joint Remedy Omega Swirl Mountain Berry, straight from the product label.

Brand Barlean's
Barcode (UPC) 705875660013
Net contents 11.2 oz.; 318 Gram(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47086
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Joint Remedy Omega Swirl Mountain Berry by Barlean's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 tsp
Maximum serving Sizes:
4 tsp
Servings per container
30
UPC/BARCODE
705875660013
IngredientAmount% DV
Calories30 {Calories}--
Total Carbohydrates4 Gram(s)1%
Calories from Fat20 {Calories}--
Saturated Fat0 Gram(s)--
Polyunsaturated Fat0 Gram(s)--
Trans Fat0 Gram(s)--
Cholesterol0 mg--
Total Fat2 Gram(s)3%
Monounsaturated Fat1.5 Gram(s)--
Vitamin E4 IU13%
Palmitoleic Acid210 mg--
Hyaluronic Acid40 mg--
Provinal Omega-7 Fatty Acid Blend420 mg--

Other ingredients: Water, Omega-7 Oil Blend, Xylitol, Glycerine, Natural Flavors, Gum Arabic, Vegetable Juice, Citric Acid, Xanthan Gum, Guar Gum, Antioxidant Blend, Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BARLEAN'S JOINT REMEDY(TM) IS A NUTRITION REVOLUTION

Proprietary Amplified Absorption(TM) Emulsification Technology

Ampliphied Absorption(TM)

General Statements

Cutting-edge nutrition and great taste finally collide!

~ Delicious Mountain Berry Smoothie Taste & Texture

Barlean's proprietary emulsification technology is designed to boost absorption and deliver significantly more nutritional value than standard supplements.

ESTd 1989

Clinically Studied to Support Healthy Joint Lubrication and Mobility* Smoothie Taste and Texture

PRODUCT OF U.S.A.

Formula

Barlean's Joint Remedy(TM) Swirl combines 210 mg of patented, pharmaceutical grade Provinal(R) Omega-7 with 40 mg of hyaluronic acid in a breakthrough joint health formula with the taste and texture of a fruit smoothie.

~ Made with Patented, Highly Purified Provinal(R) Premium Fish Oil ~ Concentrated 210 mg Omega-7 and 40 mg Hyaluronic Acid Per Serving

~ No Sugar: Naturally Sweetened with Xylitol

Concentrated Omega-7 Supplement 210 mg Omega-7 40 mg Hyaluronic Acid Per Serving

Formulation

~ No Artificial Flavors or Colors ~ No Sugar: Naturally Sweetened with Xylitol ~ Gluten Free, Non-GMO

Suggested/Recommended/Usage/Directions

SUGGESTED USE: 2 tsp daily; for increased results 4 tsp daily. Enjoy right from the bottle or add to your favorite foods and beverages.

SHAKE WELL.

Storage

Refrigerate after opening.

Precautions

Keep out of reach of children.

Do not give to pets.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

PROVINAL(R) 7 PURIFIED OMEGA-7

FROM OUR FAMILY TO YOURS {signatures}

AMPLIFIED ABSORPTION(TM) DESIGNED TO DELIVER MORE

Barlean's PATHWAY TO A BETTER LIFE

FDA Statement of Identity

SUPPLEMENT

General

69328-00

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Joint Remedy Omega Swirl Mountain Berry by Barlean's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Joint Remedy Omega Swirl Mountain Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Joint Remedy Omega Swirl Mountain Berry by Barlean's

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 tsp Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
4 IU per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Palmitoleic Acid

210 mg per serving

Hyaluronic Acid

No known
interactions
40 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Provinal Omega-7 Fatty Acid Blend

420 mg per serving

Other (inactive) ingredients: Water, Omega-7 Oil Blend, Xylitol, Glycerine, Natural Flavors, Gum Arabic, Vegetable Juice, Citric Acid, Xanthan Gum, Guar Gum, Antioxidant Blend, Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Joint Remedy Omega Swirl Mountain Berry by Barlean's Drug Interactions

Want to check YOUR meds against Joint Remedy Omega Swirl Mountain Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
764Drugs
763 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764

Individual Drug Interactions

The ingredients in Joint Remedy Omega Swirl Mountain Berry interact with 764 drugs. Click any drug to see the details.

1 of the 4 ingredients in Joint Remedy Omega Swirl Mountain Berry interact with drugs. Each result below shows which ingredient is responsible. Vitamin E

Each ingredient & the kinds of drugs it affects

For each ingredient in Joint Remedy Omega Swirl Mountain Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Joint Remedy Omega Swirl Mountain Berry, from the product label.

Barlean's

See all Barlean's products
Name
Barlean's
City
Ferndale
State
WA
ZipCode
98248
Pharmacist Counseling Corner

Joint Remedy Omega Swirl Mountain Berry by Barlean's: Common Questions

Does Joint Remedy Omega Swirl Mountain Berry by Barlean's interact with any medications?
Yes. Based on its ingredients, Joint Remedy Omega Swirl Mountain Berry has a known interaction with 764 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Joint Remedy Omega Swirl Mountain Berry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with joint pain?
The effectiveness data we hold covers vitamin E's role in specific deficiencies and a few other conditions, and hyaluronic acid for dry eye and leg ulcers. We don't have established evidence for the omega fatty acids or this combination on joint pain specifically, so talk with your doctor about whether it's right for your situation.
Is it safe if I'm pregnant?
Vitamin E is rated possibly safe in pregnancy — amounts from food and prenatal vitamins are appropriate, but avoid high-dose supplements unless your doctor directs you to. We don't have pregnancy safety data on file for hyaluronic acid or the omega fatty acids in this product, so check with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
Vitamin E is likely safe while breastfeeding at normal dietary amounts, but check with your doctor before taking high-dose supplements. The safety data we hold rates one lactation entry for hyaluronic acid as possibly unsafe, and we don't have breastfeeding information on the omega ingredients, so talk with your doctor or pharmacist before starting.
What's hyaluronic acid for in this formula?
Hyaluronic acid is a naturally occurring substance that binds water to skin and joint tissue. In this product it supports hydration and moisture retention in joints and connective tissue as part of the overall joint-health formula.
Are there any common side effects I should know about?
Vitamin E is generally well tolerated when taken by mouth. At high doses, it may increase bleeding risk. Hyaluronic acid is also generally well tolerated orally, though topical use has rarely caused eczema, itching, or skin irritation. If you notice unusual bleeding, bruising, or allergic symptoms, let your doctor or pharmacist know right away.
Does this product have fillers or just omega oils?
The product contains several inactive ingredients — water, xylitol, gums (guar and xanthan), glycerin, natural flavors, citric acid, and vegetable juice for color — along with the active omega blend, vitamin E, and hyaluronic acid. These inactive ingredients help create the liquid texture and taste.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Joint Remedy Omega Swirl Mountain Berry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Joint Remedy Omega Swirl Mountain Berry label
Go deeper

The Full Monographs Behind Joint Remedy Omega Swirl Mountain Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Joint Remedy Omega Swirl Mountain Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 68 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
  28. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40. PubMed
  29. Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev 1999;57:306-9. PubMed
  30. Brodkin RH, Bleiberg J. Sensitivity to topically applied vitamin E. Arch Dermatol 1965;92:76-7. DOI
  31. Booth SL, Golly I, Sacheck JM, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr 2004;80:143-8. PubMed
  32. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:60520-53. PubMed
  33. Lonn E, Bosch J, Yusuf S, et al. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. PubMed
  34. Landes N, Pfluger P, Kluth D, et al. Vitamin E activates gene expression via the pregnane X receptor. Biochem Pharmacol 2003;65:269-73. . PubMed
  35. Brigelius-Flohe R. Vitamin E and drug metabolism. Biochem Biophys Res Commun 2003;305:737-40. PubMed
  36. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  37. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  38. Schurks M, Glynn RJ, Rist PM, et al. Effects of vitamin E on stroke subtypes: meta-analysis of randomized controlled trials. BMJ 2010;341: c5702. doi: 10.1136/bmj.c5702.
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See these in context on the Vitamin E monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
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See these in context on the Hyaluronic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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